Mechanisms of Health and Disease at the Behavioral-Biomedical Interface

行为-生物医学界面的健康与疾病机制

• 批准号: 10619011
• 负责人: SUSAN K LUTGENDORF
• 金额: $ 23.02万
• 依托单位: UNIVERSITY OF IOWA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-07-01 至 2024-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10619011
• 关键词: Behavioral; Disease; Health

Abstract The interface of behavioral and biomedical sciences is one of the most vibrant frontiers of science today. The overarching objective of our NIGMS-funded predoctoral Training Program, Mechanisms of Health and Disease at the Behavioral-Biomedical Interface, is to train the next generation of diverse behavioral science researchers to utilize rigorous biomedical methodologies and conceptual frameworks that stretch the boundaries of their thinking and research to position them to make transformative breakthroughs in addressing issues of health and disease. The program provides predoctoral behavioral science students in the University of Iowa Department of Psychological and Brain Sciences with an integrated program of coursework and laboratory experiences. These include (1) broad-based training in the fundamentals of behavioral science including rigor and transparency, quantitative methodology and experimental design, responsible conduct of research, and key issues in health psychology, clinical psychology, and neuroscience; (2) In-depth training in pathophysiology and specific biomedical research areas (including conceptual framework, driving hypotheses, and laboratory techniques); and (3) guidance and mentoring for development and implementation of an innovative independent research program that spans both behavioral and biomedical science. The Training Program focuses on two themes: Lifespan Brain Health and Psychobiology of Chronic Disease and Women's Health. Behavioral mentors are from Psychological and Brain Sciences; Biomedical mentors come from the Colleges of Medicine, Public Health, and Nursing. Over the first 3 years of NIGMS support, we have developed a highly successful Training Program that has had far-reaching and lasting influences on a group of committed and enthusiastic students. We have used the support slots provided by the T32 grant and the two matching slots provided by the Graduate College of the U. of Iowa to recruit outstanding diverse students and to provide a catalyst for this program, which has matured into a vibrant setting for scientific exchange between behavioral science students and biomedical mentors and their labs. Since the start of the program, in addition to our 8 T32 funded students, we have had 25 additional trainees take advantage of the Training Program, including 7 diverse students. We have developed a program of seminars and retreats, featuring professional development, science communication, manuscript and grant writing, and discussions of cutting-edge research at the Behavioral-Biomedical interface. In sum, the NIGMS support for 4 students/year has returned large dividends on the investment. This renewal application requests the continuation of 4 slots per year so that we can build upon our strong foundation to continue this innovative program for another funding cycle. The program is highly relevant to public health because training at the behavioral-biomedical interface will enable these scientists to innovatively address mechanisms that influence health and disease.

抽象的 行为和生物医学科学的界面是当今科学最充满活力的边界之一。 我们由NIGMS资助的培训前培训计划，健康机制和 行为生物医学界面处的疾病是训练下一代的不同行为 科学研究人员利用严格的生物医学方法和概念框架 他们的思维和研究的界限，使他们定位，以实现变革性的突破 解决健康和疾病问题。该计划为行为科学专业学生提供 在爱荷华大学心理与脑科学系具有一体的综合计划 课程和实验室经验。其中包括（1）基于基础的基础培训 行为科学，包括严格和透明度，定量方法和实验设计， 负责任的研究以及健康心理学，临床心理学和关键问题以及 神经科学； （2）病理生理和特定生物医学研究领域的深入培训（包括 概念框架，驾驶假设和实验室技术）； （3）指导和指导 用于开发和实施创新的独立研究计划 行为和生物医学科学。培训计划侧重于两个主题：寿命脑健康 以及慢性疾病和妇女健康的心理生物学。行为导师来自心理 和脑科学；生物医学导师来自医学，公共卫生和护理学院。 在NIGMS支持的前三年，我们制定了一个非常成功的培训计划 对一群坚定而热情的学生产生了深远的影响。我们有 使用T32赠款提供的支撑插槽以及研究生提供的两个匹配插槽 爱荷华州美国学院招募杰出的学生，并为该计划提供催化剂， 这已经成长为一个充满活力的环境，以进行行为科学专业的学生和 生物医学导师及其实验室。自计划开始以来，除了我们的8个T32资助 学生，我们还有25名受训人员利用了培训计划，其中包括7种不同的学员 学生。我们已经开发了一个研讨会和务虚会的计划，包括专业发展， 科学沟通，手稿和赠款写作，以及关于尖端研究的讨论 行为生物医学界面。总而言之，4个学生/年的NIGMS支持返回了很大 投资股息。此续签申请要求每年延续4个插槽，以便 我们可以基于坚强的基础，继续这项创新计划，以进行另一个融资周期。 该计划与公共卫生高度相关，因为行为生物医学接口的培训将 使这些科学家能够创新地解决影响健康和疾病的机制。

项目成果

Nonimprovement in Chronic Fatigue Syndrome: Relation to Activity Patterns, Uplifts and Hassles, and Autonomic Dysfunction.

• DOI: 10.1097/psy.0000000000001082
• 发表时间: 2022-07-01
• 期刊: PSYCHOSOMATIC MEDICINE
• 影响因子: 3.3
• 作者: Friedberg, Fred;Adamowicz, Jenna L.;Bruckenthal, Patricia;Milazzo, Maria;Ramjan, Sameera;Quintana, Daniel
• 通讯作者: Quintana, Daniel

Maternal depressive symptoms and maternal child-directed speech: A systematic review.

• DOI: 10.1016/j.jad.2021.10.015
• 发表时间: 2022-01-15
• 期刊: Journal of affective disorders
• 影响因子: 6.6
• 作者: Scheiber FA;Ryckman KK;Demir-Lira ÖE
• 通讯作者: Demir-Lira ÖE

Emotion regulation in older adulthood: roles of executive functioning and social relationships.

老年期的情绪调节：执行功能和社会关系的作用。

• DOI: 10.1080/13825585.2022.2027331
• 发表时间: 2023
• 期刊: Neuropsychology, development, and cognition. Section B, Aging, neuropsychology and cognition
• 作者: KingJohnson,MarcieL;Roche,AnneI;Markon,Kristian;Denburg,NatalieL
• 通讯作者: Denburg,NatalieL

Genetic Associations with Gestational Duration and Spontaneous Preterm Birth.

• DOI: 10.1056/nejmoa1612665
• 发表时间: 2017-09-21
• 期刊: The New England journal of medicine
• 作者: Zhang G;Feenstra B;Bacelis J;Liu X;Muglia LM;Juodakis J;Miller DE;Litterman N;Jiang PP;Russell L;Hinds DA;Hu Y;Weirauch MT;Chen X;Chavan AR;Wagner GP;Pavličev M;Nnamani MC;Maziarz J;Karjalainen MK;Rämet M;Sengpiel V;Geller F;Boyd HA;Palotie A;Momany A;Bedell B;Ryckman KK;Huusko JM;Forney CR;Kottyan LC;Hallman M;Teramo K;Nohr EA;Davey Smith G;Melbye M;Jacobsson B;Muglia LJ
• 通讯作者: Muglia LJ

Nutritional supplementation boosts aerobic exercise effects on functional brain systems.

• DOI: 10.1152/japplphysiol.00917.2017
• 发表时间: 2019-01
• 期刊: Journal of applied physiology
• 影响因子: 3.3
• 作者: M. Voss;Matthew J Sutterer;Timothy B. Weng;Agnieszka Z. Burzynska;Jason T. Fanning;Elizabeth A. Salerno;N. Gothe;Diane K. Ehlers;E. McAuley;A. Kramer