Training of Arthritis Research Scientists

关节炎研究科学家的培训

• 批准号: 10463710
• 负责人: Jason Knight
• 金额: $ 30.31万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10463710
• 关键词: Arthritis; Research; Scientist; Training

ABSTRACT Rheumatic and autoimmune diseases remain poorly understood, are difficult to manage and treat, and often result in significant morbidity and mortality. This status quo can only be changed by focusing on research efforts that build upon and advance the knowledge that has been generated, re-evaluating current dogmas, and taking advantage of an interdisciplinary collaborative approach to effectively understand these complex multi-system diseases. Unparalleled scientific expansion in genomics, epigenomics, and systems biology has fundamentally enhanced our understanding of human biology, and generated a wealth of data and a unique opportunity to comprehensively investigate the mechanisms underlying human autoimmune diseases. Further, advances in clinical sciences have created outstanding research opportunities to improve patient outcomes. The goal of this Training Grant is to prepare the next generation of researchers to become independent investigators, and lead future efforts to improve care of patients affected by rheumatic and autoimmune diseases. This will be accomplished by selecting the most promising postdoctoral trainee candidates, and providing them with the knowledge and skills for a proposed training period of at least 2 years to prepare them for independence. Our Training Program will include 4 physician-scientists or scientists each year and will prepare them through a carefully designed individualized didactic experience, with structured mentoring focused on both scientific and career growth. In addition, our program will prepare trainees for independence through training in scientific writing, grantsmanship, and leadership skills. This Training Program will be directed by Dr. Amr Sawalha, with Drs. David Fox and Dinesh Khanna as Associate Directors. Together, this Training Grant leadership, supported by an external advisory committee which includes 4 scientific leaders with extensive productivity and mentoring experience, provides a complementary set of expertise to ensure a successful mentoring program focused on basic, translational, and clinical research. The Training Program fosters interdisciplinary research, which is evident by a roster of experienced Program Faculty mentors spanning 15 different units. It is supported by a rich and diverse scientific environment to study autoimmunity at the University of Michigan, including two NIH-funded Autoimmunity Centers of Excellence (ACE) programs – a Basic ACE and a Clinical ACE – attesting to our strength in both basic and clinical research. Our Training Program will focus on six major scientific themes: genomics, epigenomics, and bioinformatics; systemic lupus erythematosus; inflammatory arthritis; systemic sclerosis; fibromyalgia and chronic pain; and health care policy and outcome research. There is a significant need for researchers in rheumatic and autoimmune diseases, and a pressing need for making sure that future independent researchers are well trained and equipped to lead the effort to understand the complexity of these diseases, identify novel therapeutic options, and improve patient outcomes. Indeed, our proposed Training Program comprehensively addresses these needs.

抽象的 风湿性和自身免疫性疾病仍然了解不足，难以管理和治疗，并且经常 导致明显的发病率和死亡率。只有专注于研究才能更改此状态 基于并促进已经产生的知识的努力，重新评估当前的教条， 并利用跨学科的协作方法有效理解这些复杂的 多系统疾病。基因组学，表观基因组学和系统生物学无与伦比的科学扩展具有 基本上增强了我们对人类生物学的理解，并产生了大量数据和独特的数据 有机会全面研究人类自身免疫性疾病的基础机制。更远， 临床科学的进步创造了出色的研究机会来改善患者的结果。 这项培训补助金的目标是准备下一代研究人员成为独立 调查人员，并领导未来的努力，以改善风湿病和自身免疫性影响的患者的护理 疾病。这将通过选择最有前途的博士后学员候选人和 为他们提供至少两年的拟议培训期间的知识和技能 独立。我们的培训计划每年将包括4位身体科学家或科学家 通过精心设计的个性化的教学经验来准备它们，并具有结构化的心理 专注于科学和职业发展。此外，我们的计划将为受训者准备独立 通过培训科学写作，授予技巧和领导能力。该培训计划将是 由Amr Sawalha博士导演，博士。 David Fox和Dinesh Khanna担任副董事。一起，这个 培训赠款领导，由外部咨询委员会支持，其中包括4位科学领导人 丰富的生产力和心理经验提供了一套完整的专业知识，以确保 成功的心理计划着重于基本，翻译和临床研究。培训计划 培养跨学科研究，这是经验丰富的课程教师导师的名册证明的 跨越15个不同的单元。它得到了一个丰富而多样的科学环境的支持 密歇根大学，包括两个由NIH资助的自动免疫卓越中心（ACE）计划 - A 基本ACE和临床ACE - 证明了我们在基础研究和临床研究中的力量。我们的培训 计划将重点介绍六个主要的科学主题：基因组学，表观基因组学和生物信息学；系统性狼疮 红斑;炎性关节炎；系统性硬化；纤维肌痛和慢性疼痛；和医疗保健政策 和结果研究。风湿性和自身免疫性疾病的研究人员非常需要 迫切需要确保未来的独立研究人员经过良好的培训和能力，以领导 努力了解这些疾病的复杂性，确定新颖的治疗选择并改善患者 结果。确实，我们提议的培训计划全面满足了这些需求。