Build to LEAD – Building partnerships to Link the Exposome to Autoimmune Disease

构建引领 — 建立合作伙伴关系，将暴露组与自身免疫性疾病联系起来

• 批准号: 10871040
• 负责人: Jane Hoyt Buckner
• 金额: $ 49.27万
• 依托单位: BENAROYA RESEARCH INST AT VIRGINIA MASON
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-18 至 2025-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10871040
• 关键词: Acceleration; Address; Agreement; Autoantibodies; Autoimmune; Autoimmune Diseases; Autoimmunity; Award; Cities; Climatology; Clinical; Clinical Data; Collaborations; Collection; Common Data Element; Complex; Computational Biology; Data; Development; Disease; Disease Progression; Elements; Environment; Environmental Exposure; Environmental Health; Environmental Risk Factor; Epidemiology; Exposure to; Flare; Foundations; Frequencies; Funding; Future; Genetic; Genomics; Goals; Government Agencies; Health; Human; Human Herpesvirus 4; Immune; Immune Tolerance; Immune system; Immunologics; Immunology; Individual; Infrastructure; Institution; Interdisciplinary Study; Leadership; Link; Measurement; Measures; Mediating; Medical Research; Medicine; Occupational Exposure; Oklahoma; Outcome; Participant; Patients; Persons; Pesticides; Pilot Projects; Play; Privatization; Protocols documentation; Recontacts; Research; Research Design; Research Infrastructure; Research Institute; Research Personnel; Resources; Rheumatoid Arthritis; Role; Sampling; Scientist; Severities; Severity of illness; Shapes; Site; Smoke; Smoking; System; Systemic Lupus Erythematosus; Technology; Time; United States National Institutes of Health; Universities; Washington; Widespread Disease; Wildfire; Work; biobank; cohort; data harmonization; disease registry; environmental toxicology; epigenomics; experience; implementation design; meetings; novel strategies; outcome disparities; patient oriented; sample collection; social health determinants; symposium; synergism; translational immunology

Project Summary/Abstract Environmental health researchers have identified a substantial role of the exposome in development and progression of many complex diseases, including autoimmunity. We and others have identified relationships between specific exposures, such as wildfire smoke and Epstein-Barr virus, and changes to the immune system in people with and without autoimmune disease. The overarching goal of the proposed studies is to establish a collaborative interdisciplinary research team focused on understanding the role of the exposome in autoimmune disease, specifically rheumatoid arthritis (RA), and systemic lupus erythematosus (SLE), to participate in the Exposome in Autoimmune Diseases Collaborating Teams, EXACT Network. In Specific Aim 1, we will develop a strong, formalized partnership between the Benaroya Research Institute (BRI) in Seattle and the Oklahoma Medical Research Foundation (OMRF) in Oklahoma City to define associations between a broad spectrum of environmental exposures and clinical severity/flares in RA and SLE. BRI and OMRF maintain some of the largest national biorepositories of samples from individuals with RA and SLE, with longitudinal measures of disease and ability to recontact participants. We will harmonize data related to clinical features of these autoimmune diseases across sites (e.g., autoantibodies and severity measures), and implement new, shared protocols at each site for collection of both data and samples relevant to exposome measurements. In Aim 2, we will organize and host two summit meetings for autoimmune disease researchers, environmental health and toxicology experts, geneticists, clinicians, patients, EXACT Network sites, and other stakeholders. The first summit will define and prioritize questions that are of critical importance to this emerging field, and the second summit will design an implementation plan to address these questions. In Aim 3, we will develop the teams and resources needed to conduct two pilot studies to investigate the role of the exposome in RA and SLE. The first pilot study proposes to determine the impact of wildfire smoke on the immune landscape in RA and the second pilot will determine environmental influences in SLE using geocoding. This work will establish collaborative teams and a research framework ready to address the future priorities of the EXACT Network focusing on understanding the role that exposures play in shaping autoimmune disease development and progression.

项目概要/摘要 环境健康研究人员已经确定暴露组在发育和发育过程中发挥着重要作用。 许多复杂疾病的进展，包括自身免疫性疾病。我们和其他人已经确定了关系 特定暴露（例如野火烟雾和 Epstein-Barr 病毒）与免疫系统变化之间的关系 患有或不患有自身免疫性疾病的人。拟议研究的总体目标是建立一个 跨学科协作研究团队致力于了解暴露组在自身免疫中的作用 疾病，特别是类风湿关节炎（RA）和系统性红斑狼疮（SLE），参与 自身免疫性疾病中的暴露组合作团队，EXACT 网络。在具体目标 1 中，我们将制定 西雅图贝纳罗亚研究所 (BRI) 与俄克拉荷马州研究所之间建立了牢固、正式的合作伙伴关系 俄克拉荷马城医学研究基金会 (OMRF) 定义了广泛的 RA 和 SLE 的环境暴露和临床严重程度/突发。 BRI 和 OMRF 维持着一些最大的 RA 和 SLE 患者样本的国家生物样本库，对疾病和症状进行纵向测量 重新联系参与者的能力。我们将协调与这些自身免疫性疾病临床特征相关的数据 跨站点（例如，自身抗体和严重程度测量），并在每个站点实施新的共享协议 收集与暴露组测量相关的数据和样本。在目标 2 中，我们将组织并主办 两次自身免疫性疾病研究人员、环境健康和毒理学专家峰会， 遗传学家、临床医生、患者、EXACT 网络站点和其他利益相关者。第一次峰会将定义和 优先考虑对这个新兴领域至关重要的问题，第二次峰会将设计一个 实施计划来解决这些问题。在目标 3 中，我们将培养所需的团队和资源 进行两项试点研究来调查暴露组在 RA 和 SLE 中的作用。第一项试点研究提出 确定野火烟雾对 RA 免疫环境的影响，第二个试点将确定 使用地理编码评估 SLE 中的环境影响。这项工作将建立协作团队和研究 框架准备好解决 EXACT 网络未来的优先事项，重点是了解 暴露在影响自身免疫性疾病的发生和进展中发挥着作用。