Scientist Training in Rheumatology Research

风湿病学研究科学家培训

• 批准号: 10627099
• 负责人: Jason Knight
• 金额: $ 35.34万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 1976
• 资助国家: 美国
• 起止时间: 1976-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10627099
• 关键词: Research; Rheumatology; Scientist; Training

PROJECT SUMMARY / ABSTRACT This application is a competitive renewal of the University of Michigan's Program for Scientist Training in Rheumatology Research (T32AR007080). Our Program, funded by NIAMS since 1975, is designed to prepare four outstanding postdoctoral scientists per year, both MD and PhD, for investigative careers in research related to the rheumatic diseases. Our Program is motivated by several key factors including (i) the tremendous clinical need caused by the unrelenting burden of rheumatic diseases; (ii) an appreciation that rheumatic diseases are propelled by complex processes in need of multidisciplinary approaches; and (iii) a threatened pipeline of diverse investigators committed to careers that will be devoted to rheumatology research. Fortunately, recent advances in biomedical and clinical sciences have created unprecedented research opportunities to understand disease etiologies more deeply—and ultimately improve outcomes through an approach personalized to the care of each individual living with a rheumatic disease. Our 22 Program faculty mentors are dedicated researcher-mentors who together bring broad interdisciplinary expertise focused on rheumatic diseases. These investigators have established extensive collaborations with research units nationally and internationally to effectively study rheumatic disease mechanisms and improve management. Leveraging these historical strengths, our Program's themes have been updated to align with NIAMS strategic mission “to transcend disease- and tissue-specific boundaries via cross-cutting scientific themes.” For the upcoming cycle of our Program, major scientific themes will include (i) Biologic Underpinnings of Clinical Heterogeneity; (ii) Immunological Mechanisms of Disease; (iii) Injury, Repair, and Fibrosis; and (iv) Patient Outcomes/Experience and Innovative Trials. Trainees are also provided strong roots in the ethical conduction of research, and in embracing a culture of diversity, equity, and inclusion. Some additional highlights of the Training Program include: (i) the availability of an award-winning 10-week research training course offered to physician trainees with a strong interest in basic research; (ii) multiple paths for trainees to earn a master's degree concurrent with their Program training, and (iii) outstanding state-of-the-art biomedical cores that provide training, consultations, and scientific services commensurate with U-M's standing as the top public research institution in the United States. It has been a longstanding mission of our Program to train individuals from diverse backgrounds for careers in research. Of the 26 trainees since 2009, 17 (65%) are women and eight (31%) come from underrepresented backgrounds (1 Black, 5 Hispanic or Latinx, and 2 from disadvantaged backgrounds); half of the current trainees identify as underrepresented minorities. Of the 20 trainees (9 MD and 11 PhD) who have completed their participation in our Program since 2011, all 20 remain involved in research. Fourteen of the 20 (70%) are working in research-intensive careers, and ten have successfully competed for grant funding (~70 grants have been awarded to the group as PI).

项目概要/摘要 该申请是密歇根大学科学家培训计划的竞争性更新 风湿病学研究 (T32AR007080) 我们的项目自 1975 年起由 NIAMS 资助，旨在 每年培养四名杰出的博士后科学家，包括医学博士和博士，从事以下领域的研究职业 与风湿性疾病相关的研究是由几个关键因素推动的，包括 (i) 风湿性疾病的持续负担造成巨大的临床需求； 风湿性疾病是由需要多学科方法的复杂过程推动的； 致力于风湿病学职业的不同研究人员的管道受到威胁 幸运的是，生物医学和临床科学的最新进展创造了前所未有的成果。 更深入地了解疾病病因并最终改善结果的研究机会 通过针对每个风湿病患者的个性化护理方法 Our 22。 项目教师导师是专门的研究人员导师，他们共同带来了广泛的跨学科 这些研究人员与风湿病领域的专家建立了广泛的合作。 国内外研究单位共同研究风湿病发病机制并有效改善 利用这些历史优势，我们的计划主题已更新以符合管理要求。 NIAMS 的战略使命是“通过跨领域科学超越疾病和组织特异性界限” 对于我们计划的下一个周期，主要科学主题将包括 (i) 生物学基础 临床异质性；(ii) 疾病的免疫机制；(iii) 损伤、修复和纤维化； 患者结果/经验和创新试验也为学员提供了坚实的道德基础。 进行研究，并拥抱多样性、公平和包容的文化。 培训计划的亮点包括：(i) 提供为期 10 周的获奖研究培训 为对基础研究有浓厚兴趣的实习医师提供课程；(ii) 为实习生提供多种途径； 在计划培训的同时获得硕士学位，以及（iii）杰出的最先进的生物医学 提供与密歇根大学顶尖地位相称的培训、咨询和科学服务的核心 培训是美国的公共研究机构。 自 2009 年以来的 26 名学员中，有 17 名 (65%) 是来自不同背景的研究人员。 女性和 8 名 (31%) 来自代表性不足的背景（1 名黑人、5 名西班牙裔或拉丁裔，以及 2 来自弱势背景）；目前的学员中有一半被认为是代表性不足的少数群体。 自 2011 年以来完成我们项目的 20 名学员（9 名医学博士和 11 名博士），全部 20 20 人中，有 14 人 (70%) 从事研究密集型职业，其中 10 人已经从事研究工作。 成功竞争拨款资助（作为 PI，该小组已获得约 70 项拨款）。