St. Jude Children's Research Hospital - Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) Operations and Collaborations Center (UM2 Clinical Trial Optional)

圣裘德儿童研究医院 - 艾滋病毒/艾滋病干预青少年医学试验网络 (ATN) 运营和合作中心（UM2 临床试验可选）

• 批准号: 10709610
• 负责人: Aditya H Gaur
• 金额: $ 45.17万
• 依托单位: WESTAT, INC.
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-22 至 2029-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10709610
• 关键词: Academia; Acquired Immunodeficiency Syndrome; Address; Adolescent; Adolescent Medicine; Adolescent Medicine Trials Network; African American population; Age; Area; Arkansas; Behavioral; Black Populations; Cities; Clinic; Clinical; Clinical Research; Clinical Trials; Clinical Trials Design; Collaborations; Communities; County; Development; Diagnosis; Epidemic; Funding; General Population; Geography; HIV; HIV Infections; HIV/AIDS; Health; Healthcare; Human Resources; Income; Individual; Infection; Infrastructure; Intervention; Intervention Studies; Investments; Laboratories; Leadership; Minor; Mississippi; Missouri; Names; Persons; Pharmacy facility; Policies; Population; Poverty; Public Health; Radial; Research Infrastructure; Research Personnel; Risk; Saint Jude Children' s Research Hospital; Schools; Site; Strategic Planning; Tennessee; Therapeutic; Thinking; United States; Universities; Writing; Youth; clinical development; clinical research site; clinical trial implementation; community organizations; community partnership; comorbidity; design; fortification; infection rate; innovation; interest; meetings; metropolitan; microbicide; novel; novel strategies; operation; pandemic disease; prevent; recruit; research facility; rural area; urban area; vaccine trial; virtual

ABSTRACT St. Jude Children's Research Hospital The Adolescent Medicine Trials Network for HIV/AIDS Interventions (ATN) aims over the 7-year funding cycle to develop and conduct innovative behavioral, community-based, translational, therapeutic, microbicide, and vaccine trials in youth ages 13-24 years at-risk for HIV and living with HIV, with a focus on the inclusion of minors. The ATN seeks investigators with innovative thinking and novel approaches to address the public health issues facing adolescents. The St. Jude Memphis Site Consortium (SMSC), based in Memphis located in the Shelby County of TN has (1) a well-established clinical and clinical research facility at St. Jude Children's Research Hospital (former ATN site), (2) A long-standing Connect to Protect Memphis Coalition (C2P Memphis) of over 25 stakeholders (Community Based organizations, Non for Profit Groups, Memphis Schools, etc.) invested in the interests of youth and (3) established partnerships including with academia (University of Tennessee) and the local Shelby County and Tennessee state health departments. Shelby County is an Ending the HIV Epidemic Priority jurisdiction. The SMSC closely collaborating with the Westat led ATN Operations and Collaborations Center (OCC) will participate in the development of clinical trials and provide the clinical research site(s), local laboratory capacity, and investigational pharmacy support to further the ATN Research agenda. Taking the clinical trials to youth at risk of HIV and those living with HIV who are not aware of their diagnosis will require using innovative approaches for recruitment which the SMSC has demonstrated in the past and looks forward to building on. The C2P Memphis Coalition and a separate youth community advisory board will over the project period be instrumental in providing input both for clinical trial design as well as youth engagement and retention approaches.

摘要 圣裘德儿童研究医院 HIV/艾滋病干预青少年医学试验网络 (ATN) 的目标是 7 年资助周期 开发和开展创新行为、基于社区、转化、治疗、杀菌剂和 在 13-24 岁有艾滋病毒风险和感染艾滋病毒的青少年中进行疫苗试验，重点是纳入 未成年人。 ATN 寻求具有创新思维和新颖方法的调查人员来向公众发表讲话 青少年面临的健康问题。圣裘德孟菲斯站点联盟 (SMSC)，总部位于孟菲斯，位于 田纳西州谢尔比县的圣裘德儿童医院 (1) 拥有完善的临床和临床研究设施 研究医院（前 ATN 站点），(2) 长期存在的连接保护孟菲斯联盟 (C2P 孟菲斯）超过 25 个利益相关者（社区组织、非营利组织、孟菲斯学校、 等）投资于青年的利益，（3）建立伙伴关系，包括与学术界（南非大学） 田纳西州）以及当地谢尔比县和田纳西州卫生部门。谢尔比县是 结束艾滋病毒流行优先管辖权。 SMSC 与 Westat 领导的 ATN 密切合作 运营与合作中心（OCC）将参与临床试验的开发并提供 临床研究中心、当地实验室能力和研究药房支持以进一步推进 ATN 研究议程。对有艾滋病毒风险的青少年和不知情的艾滋病毒感染者进行临床试验 他们的诊断需要使用创新的招募方法，SMSC 已经证明了这一点 过去并期待着继续发展。 C2P 孟菲斯联盟和一个独立的青年社区 顾问委员会将在项目期间为临床试验设计提供意见 随着青年参与度和保留率的接近。