St. Jude-Memphis Adolescent Trials Unit

圣裘德-孟菲斯青少年试验中心

• 批准号: 8619645
• 负责人: Aditya H Gaur
• 金额: $ 70.39万
• 依托单位: ST. JUDE CHILDREN'S RESEARCH HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-03-03 至 2016-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8619645
• 关键词: Adolescent; Adolescent Medicine; Adolescent Medicine Trials Network; Affect; African American; Behavioral; Caring; Clinical Research; Clinical Research Protocols; Clinical Trials; Collaborations; Communities; Comprehensive Health Care; County; Enrollment; Ensure; Environment; Epidemic; HIV; HIV Infections; Health; Human Resources; Human immunodeficiency virus test; Location; Newly Diagnosed; Patient Care; Patients; Prevention; Preventive; Primary Prevention; Principal Investigator; Prophylactic treatment; Protocols documentation; Provider; Research Infrastructure; Research Personnel; Resources; Risk; Saint Jude Children' s Research Hospital; Secondary Prevention; Services; Sexually Transmitted Diseases; Site; Tennessee; United States; Vaccines; Youth; base; clinical care; clinical research site; community organizations; experience; improved; intervention program; microbicide; multidisciplinary; outreach; programs; protocol development; tertiary prevention

DESCRIPTION (provided by applicant): Prevention and treatment efforts in HIV infected or at risk youth require a collaborative effort between clinical research sites with multidisciplinary staff experienced in adolescent medicine, and community organizations such as local health departments, youth service providers, HIV community based organizations and faith based organizations. Such collaboration and a youth friendly environment with creative approaches to successful accrual and retention of youth in clinical studies exist at the St. Jude Memphis Adolescent Trials Unit (ATU). The specific aims of this proposal from a re-competing ATU in Memphis are: 1) To maintain the clinical research infrastructure that supports the Adolescent Medicine Trials Network's (ATN) scientific agenda through the recruitment and retention of HIV-infected and at-risk HIV-uninfected youth into primary, secondary and tertiary prevention studies. 2) To enhance secondary prevention efforts by improving linkage to care of patients newly diagnosed with HIV. 3) To expand and optimize new and existing community linkages that maintain a community-based primary prevention infrastructure that will support HIV preventive biomedical clinical trials, including vaccines, microbicides, pre-exposure prophylaxis and integrated biomedical and behavioral trials. 4) To contribute to the scientific agenda of the Adolescent Medicine Trials Network through the participation of investigators and site personnel in the development of protocols. Memphis, located in the county with the highest sexually transmitted disease rates in Tennessee and with a predominantly black population has been particularly affected by the HIV epidemic. Since its inception in 1987, the St. Jude HIV program has actively participated in clinical research. With 319 enrollments in ATN protocols since joining the network in 2006, the St. Jude Memphis ATU has earned its place as a top performing ATU and looks forward to furthering the ATN scientific agenda in the coming years. Increasing HIV testing amongst youth, improving linkage to care through outreach, and continuing to provide comprehensive care and resources to support engagement and retention in clinical care and research protocols are some of the major components of the St. Jude Memphis ATU's proposed plan. RELEVANCE: In the United States, HIV infection rates are increasing most rapidly among youth, in blacks, and in the South. An intervention program in Memphis, with its location in the South, a predominantly black population, and high STD rates, is poised to have a significant impact on this epidemic. The outstanding comprehensive HIV care and clinical research experience at St. Jude ensure a high-performing program.

说明（由申请人提供）：艾滋病毒感染者或高危青少年的预防和治疗工作需要临床研究中心与青少年医学方面经验丰富的多学科工作人员以及社区组织（例如当地卫生部门、青少年服务提供者、艾滋病毒社区）之间的合作。组织和基于信仰的组织。圣裘德孟菲斯青少年试验中心 (ATU) 存在这样的合作和青年友好环境，以及在临床研究中成功招募和保留青年的创造性方法。孟菲斯重新竞争的 ATU 提案的具体目标是： 1) 通过招募和保留 HIV 感染者和高危 HIV 患者，维持支持青少年医学试验网络 (ATN) 科学议程的临床研究基础设施- 将未感染的青少年纳入一级、二级和三级预防研究。 2) 通过改善新诊断艾滋病毒患者的护理联系，加强二级预防工作。 3) 扩大和优化新的和现有的社区联系，维持以社区为基础的初级预防基础设施，支持艾滋病毒预防性生物医学临床试验，包括疫苗、杀菌剂、暴露前预防以及综合生物医学和行为试验。 4) 通过研究人员和现场工作人员参与方案制定，为青少年医学试验网络的科学议程做出贡献。孟菲斯位于田纳西州性传播疾病发病率最高的县，人口以黑人为主，受到艾滋病毒流行的影响尤其严重。自1987年启动以来，圣裘德艾滋病毒项目积极参与临床研究。自 2006 年加入网络以来，已有 319 名 ATN 协议注册者，St. Jude Memphis ATU 已赢得了表现最佳 ATU 的地位，并期待在未来几年进一步推进 ATN 科学议程。增加青少年中的艾滋病毒检测，通过外展改善与护理的联系，以及继续提供全面的护理和资源以支持临床护理和研究方案的参与和保留，是圣裘德孟菲斯 ATU 拟议计划的一些主要组成部分。 相关性：在美国，艾滋病毒感染率在青少年、黑人和南方地区增长最快。孟菲斯位于南部，人口以黑人为主，性病发病率很高，因此一项干预计划将对这一流行病产生重大影响。圣裘德杰出的综合艾滋病毒护理和临床研究经验确保了项目的高绩效。