Patient oriented research and mentoring program in dermatologic diseases

以患者为中心的皮肤病研究和指导计划

• 批准号: 10685455
• 负责人: MARYAM Mandana ASGARI
• 金额: $ 19.24万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-05-02 至 2026-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10685455
• 关键词: Address; Applications Grants; Award; Carcinoma; Clinical; Clinical Investigator; Cutaneous; DNA; Data; Data Set; Dermatologic; Dermatology; Development; Development Plans; Diagnostic; Disease; Disease Progression; Educational Status; Environment; Environmental Risk Factor; Epidemiology; Epigenetic Process; Faculty; Feedback; Foundations; Funding; Gene Combinations; Gene Expression; General Hospitals; Genetic; Genotype; Genotype-Tissue Expression Project; Goals; Growth; Individual; Institution; Investments; K-Series Research Career Programs; Knowledge; Laboratories; Leadership; Learning; Massachusetts; Measurement; Medical Students; Medicine; Mentored Patient-Oriented Research Career Development Award; Mentors; Mentorship; Mid-Career Clinical Scientist Award (K24); Modification; Mohs Surgery; Molecular; National Institute of Arthritis, and Musculoskeletal, and Skin Diseases; Outcome; Parents; Pathology; Patient Self-Report; Patients; Peer Review; Peer Review Grants; Physicians; Play; Population; Positioning Attribute; Postdoctoral Fellow; Principal Investigator; Productivity; Publications; Research; Research Activity; Research Assistant; Research Personnel; Research Project Grants; Research Support; Residencies; Risk; Role; Scientist; Skin Cancer; Structure; Surgeon; Time; Tissues; Training; Training and Education; United States National Institutes of Health; Work; cancer care; cancer initiation; carcinogenesis; care delivery; career; career development; catalyst; dietary supplements; disease prognostic; disorder risk; epigenomics; experience; gene function; genome-wide; innovation; insight; keratinocyte; medical schools; novel; patient engagement; patient oriented; patient oriented research; professor; prognostic indicator; programs; public health relevance; research study; secondary analysis; shared decision making; skills; skin disorder; skin organogenesis; synergism; tool; training opportunity; tumorigenesis

Abstract The overall goals of this K24 renewal application are to continue to provide Maryam Asgari MD, MPH with protected time to serve as a mentor to junior clinical investigators, and to support new scientific aims that will build upon Dr. Asgari's established work on patient-oriented research in skin diseases. Dr. Asgari is a nationally recognized dermatoepidemiologist and Mohs surgeon and the Director of the Patient-Oriented Research in the Epidemiology of Skin Diseases (PORES) unit at Harvard Medical School. She is the principal investigator of several large patient-oriented research studies, including two NIH-funded R01s examining genetic and environmental factors impacting the development of skin cancer. The parent K24 award has allowed Dr. Asgari the protected time to successfully mentor over 30 trainees ranging from medical students to junior faculty. This K24 renewal award would allow her to 1) continue mentoring junior investigators, particularly NIH K23 awardees, 2) pursue new research in cutaneous carcinogenesis with a renewed focus on epigenomic changes in carcinogenesis and the role of dietary supplements in keratinocyte carcinoma risk, and 3) establish a new research direction focused on shared decision making in skin cancer care. The research plan (Aim 1) builds on an ongoing NIAMS- and NCI-funded portfolio of projects led by Dr. Asgari. The proposed new aims will take advantage of existing data from these R01 awards and allow mentees the ability to use existing datasets to examine novel topics in keratinocyte carcinogenesis. This renewal will be an important catalyst for Dr. Asgari’s professional growth by enabling her to learn and conduct innovative patient-facing research involving shared decision making in keratinocyte carcinoma management. The mentoring plan (Aim 2) in this continuation period will allow for the implementation of a structured mentoring program tailored at the individual level to engage mentees using a formal individual development plan. Mentoring outcomes will be assessed using a validated tool for anonymous feedback from mentees, and mentoring skills will be refined by utilizing a mentoring coach. Dr. Asgari will continue her successful trajectory of providing direct mentorship to dermatology residents, research fellows, and junior faculty at her institution. Her plan for the next 5 years is to leverage her efforts for career development of patient-oriented researchers at the national level. This K24 renewal will be an important catalyst for Dr. Asgari’s professional growth by enabling her to conduct innovative research and mentor new investigators on performing patient-oriented dermatologic research. The mentoring and research activities in this plan will open new opportunities for a long-term professional trajectory that would not be attainable without a renewal period. By supporting Dr. Asgari’s efforts in mentoring, the award is an excellent investment in the junior investigators at her institution.

抽象的 此K24更新申请的总体目标是继续为Maryam Asgari MD提供MPH， 受保护的时间作为初级临床研究人员的心理，并支持新的科学目标 基于Asgari博士在皮肤疾病中以患者为导向的研究的既定工作。 Asgari博士是 全国认可的Dermatoepidemiogist和MOHS外科医生以及以患者为导向的主任 哈佛医学院的皮肤病流行病学（孔）单元的研究。她是校长 一些大型注重患者研究的研究者，包括两项由NIH资助的R01检查 影响皮肤癌发展的遗传和环境因素。家长K24奖有 允许受保护的时间阿斯加里博士成功地精神上的30多名学员，从医学生到 初级教师。这项K24更新奖将使她获得1）持续心理的初级调查人员， 特别是NIH K23获奖者，2）从事皮肤致癌的新研究，重点是 癌变的表观基因组变化以及饮食补充剂在角质形成细胞癌中的作用，以及 3）建立一个新的研究方向，重点是皮肤癌护理中的共同决策。 研究计划（AIM 1）建立在由Dr. 阿斯加里。拟议的新目标将利用这些R01奖项中的现有数据，并允许威胁 使用现有数据集检查角质形成癌的新主题的能力。这个更新将是 Asgari博士的专业成长的重要催化剂，使她能够学习和进行创新 面向患者的研究涉及角质细胞癌管理中的决策。 在这个延续期间的心理计划（AIM 2）将允许实施结构化 在个人级别量身定制的指导计划使用正式的个人发展与Menetes一起参与 计划。指导成果将使用经过验证的工具来评估月经中的匿名反馈，以及 通过使用指导教练，将精炼指导技能。 Asgari博士将继续她的成功轨迹 为其机构的皮肤病学居民，研究研究员和初级教师提供直接心态。 她未来5年的计划是利用她的努力为以患者为导向的研究人员的职业发展 在国家一级。 这种K24更新将是Asgari博士专业成长的重要催化剂，使她能够 进行创新的研究和指导新的研究人员，以执行面向患者的皮肤病学 研究。该计划中的心理和研究活动将为长期带来新的机会 如果没有续期，专业轨迹将是无法实现的。通过支持Asgari博士的努力 在心理方面，该奖项是对她机构的初级调查人员的出色投资。

项目成果

Relationship between body mass index and atopic dermatitis: a Mendelian randomization approach in exploring causality: a critical appraisal.

• DOI: 10.1111/bjd.19702
• 发表时间: 2021-06
• 期刊: The British journal of dermatology
• 作者: Pan CX;Jee YH;Moore KJ;Kraft P;Asgari MM
• 通讯作者: Asgari MM

Leveraging the electronic health record to improve dermatologic care delivery: The importance of finding structure in data.

• DOI: 10.1016/j.jaad.2019.10.064
• 发表时间: 2020-03
• 期刊: Journal of the American Academy of Dermatology
• 影响因子: 13.8
• 作者: Park AJ;Weintraub GS;Asgari MM
• 通讯作者: Asgari MM

Association between Human Leukocyte Antigen Type and Keratinocyte Carcinoma Risk in Renal Transplant Recipients.

• DOI: 10.1016/j.jid.2019.09.016
• 发表时间: 2020-05
• 期刊: The Journal of investigative dermatology
• 作者: Kim Y;Wojciechowski D;Pattanayak V;Lee H;Asgari MM
• 通讯作者: Asgari MM

Epigenetic Alterations in Keratinocyte Carcinoma.

• DOI: 10.1016/j.jid.2020.10.018
• 发表时间: 2021-05
• 期刊: The Journal of investigative dermatology
• 作者: Yao Q;Epstein CB;Banskota S;Issner R;Kim Y;Bernstein BE;Pinello L;Asgari MM
• 通讯作者: Asgari MM

The effectiveness of an electronic clinical-decision support tool embedded into the patient medical record at the point of care to guide Mohs surgery utilization: A cohort study.

在护理点嵌入患者病历中的电子临床决策支持工具指导莫氏手术使用的有效性：一项队列研究。

• DOI: 10.1016/j.jaad.2021.06.886
• 发表时间: 2022
• 期刊: Journal of the American Academy of Dermatology
• 影响因子: 13.8
• 作者: Ashrafzadeh,Sepideh;Gupta,Sameer;Fiorino,Anne-Maria;Cafiero-Fonseca,ElizabethT;Ferris,TimothyG;Asgari,MaryamM
• 通讯作者: Asgari,MaryamM