Patient oriented research and mentoring program in dermatologic diseases

以患者为中心的皮肤病研究和指导计划

基本信息

批准号：
10685455
负责人：
MARYAM Mandana ASGARI
金额：
$ 19.24万
依托单位：
UNIVERSITY OF COLORADO DENVER
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-05-02 至 2026-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10685455
关键词：
Address Applications Grants Award Carcinoma Clinical Clinical Investigator Cutaneous DNA Data Data Set Dermatologic Dermatology Development Development Plans Diagnostic Disease Disease Progression Educational Status Environment Environmental Risk Factor Epidemiology Epigenetic Process Faculty Feedback Foundations Funding Gene Combinations Gene Expression General Hospitals Genetic Genotype Genotype-Tissue Expression Project Goals Growth Individual Institution Investments K-Series Research Career Programs Knowledge Laboratories Leadership Learning Massachusetts Measurement Medical Students Medicine Mentored Patient-Oriented Research Career Development Award Mentors Mentorship Mid-Career Clinical Scientist Award (K24)Modification Mohs Surgery Molecular National Institute of Arthritis, and Musculoskeletal, and Skin Diseases Outcome Parents Pathology Patient Self-Report Patients Peer Review Peer Review Grants Physicians Play Population Positioning Attribute Postdoctoral Fellow Principal Investigator Productivity Publications Research Research Activity Research Assistant Research Personnel Research Project Grants Research Support Residencies Risk Role Scientist Skin Cancer Structure Surgeon Time Tissues Training Training and Education United States National Institutes of Health Work cancer care cancer initiation carcinogenesis care delivery career career development catalyst dietary supplements disease prognostic disorder risk epigenomics experience gene function genome-wide innovation insight keratinocyte medical schools novel patient engagement patient oriented patient oriented research professor prognostic indicator programs public health relevance research study secondary analysis shared decision making skills skin disorder skin organogenesis synergism tool training opportunity tumorigenesis

项目摘要

Abstract The overall goals of this K24 renewal application are to continue to provide Maryam Asgari MD, MPH with protected time to serve as a mentor to junior clinical investigators, and to support new scientific aims that will build upon Dr. Asgari's established work on patient-oriented research in skin diseases. Dr. Asgari is a nationally recognized dermatoepidemiologist and Mohs surgeon and the Director of the Patient-Oriented Research in the Epidemiology of Skin Diseases (PORES) unit at Harvard Medical School. She is the principal investigator of several large patient-oriented research studies, including two NIH-funded R01s examining genetic and environmental factors impacting the development of skin cancer. The parent K24 award has allowed Dr. Asgari the protected time to successfully mentor over 30 trainees ranging from medical students to junior faculty. This K24 renewal award would allow her to 1) continue mentoring junior investigators, particularly NIH K23 awardees, 2) pursue new research in cutaneous carcinogenesis with a renewed focus on epigenomic changes in carcinogenesis and the role of dietary supplements in keratinocyte carcinoma risk, and 3) establish a new research direction focused on shared decision making in skin cancer care. The research plan (Aim 1) builds on an ongoing NIAMS- and NCI-funded portfolio of projects led by Dr. Asgari. The proposed new aims will take advantage of existing data from these R01 awards and allow mentees the ability to use existing datasets to examine novel topics in keratinocyte carcinogenesis. This renewal will be an important catalyst for Dr. Asgari’s professional growth by enabling her to learn and conduct innovative patient-facing research involving shared decision making in keratinocyte carcinoma management. The mentoring plan (Aim 2) in this continuation period will allow for the implementation of a structured mentoring program tailored at the individual level to engage mentees using a formal individual development plan. Mentoring outcomes will be assessed using a validated tool for anonymous feedback from mentees, and mentoring skills will be refined by utilizing a mentoring coach. Dr. Asgari will continue her successful trajectory of providing direct mentorship to dermatology residents, research fellows, and junior faculty at her institution. Her plan for the next 5 years is to leverage her efforts for career development of patient-oriented researchers at the national level. This K24 renewal will be an important catalyst for Dr. Asgari’s professional growth by enabling her to conduct innovative research and mentor new investigators on performing patient-oriented dermatologic research. The mentoring and research activities in this plan will open new opportunities for a long-term professional trajectory that would not be attainable without a renewal period. By supporting Dr. Asgari’s efforts in mentoring, the award is an excellent investment in the junior investigators at her institution.

抽象的此 K24 续签申请的总体目标是继续为 Maryam Asgari MD、MPH 提供受保护的时间担任初级临床研究人员的导师，并支持新的科学目标建立在阿斯加里博士以患者为导向的皮肤病研究的基础上。国家认可的皮肤流行病学家和莫氏外科医生以及以患者为中心的主任她是哈佛医学院皮肤病流行病学 (PORES) 部门的负责人。多项大型以患者为导向的研究的调查员，其中包括两项 NIH 资助的 R01 研究遗传和环境因素影响皮肤癌的发展。让 Asgari 博士有受保护的时间成功指导了 30 多名学员，从医学生到这个 K24 续签奖将使她能够 1) 继续指导初级研究人员，特别是 NIH K23 获奖者，2) 追求皮肤癌发生的新研究，并重新关注致癌作用中的表观基因组变化以及膳食补充剂在角化细胞癌风险中的作用，以及 3）建立一个新的研究方向，重点关注皮肤癌护理中的共同决策。该研究计划（目标 1）建立在 NIAMS 和 NCI 资助的、由 NIAMS 博士领导的正在进行的项目组合的基础上。 Asgari 提出的新目标将利用这些 R01 奖项的现有数据并允许受训者使用现有数据集来检查角质形成细胞癌变的新主题的能力将是这种更新。阿斯加里博士的专业成长的重要催化剂，使她能够学习和进行创新涉及角化细胞癌管理中共同决策的面向患者的研究。在此持续期内的指导计划（目标 2）将允许实施结构化的在个人层面量身定制的指导计划，通过正式的个人发展来吸引受指导者将使用经过验证的工具来评估指导结果，以获取受指导者的匿名反馈，以及阿斯加里博士将通过指导教练来提高指导技能，继续她的成功之路。为她所在机构的皮肤科住院医师、研究员和初级教师提供直接指导。她未来5年的计划是利用她的努力促进以患者为中心的研究人员的职业发展在国家层面。这次 K24 更新将成为 Asgari 博士职业发展的重要催化剂，使她能够进行创新研究并指导新研究人员进行以患者为导向的皮肤病学研究该计划中的指导和研究活动将为长期研究开辟新的机会。如果没有更新期，就无法实现职业轨迹。在指导方面，该奖项是对她所在机构的初级研究人员的一项出色投资。

项目成果

期刊论文数量（39）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Relationship between body mass index and atopic dermatitis: a Mendelian randomization approach in exploring causality: a critical appraisal.

DOI：
10.1111/bjd.19702
发表时间：
2021-06
期刊：
The British journal of dermatology
影响因子：
0
作者：
Pan CX;Jee YH;Moore KJ;Kraft P;Asgari MM
通讯作者：
Asgari MM

Leveraging the electronic health record to improve dermatologic care delivery: The importance of finding structure in data.

DOI：
10.1016/j.jaad.2019.10.064
发表时间：
2020-03
期刊：
Journal of the American Academy of Dermatology
影响因子：
13.8
作者：
Park AJ;Weintraub GS;Asgari MM
通讯作者：
Asgari MM

The effectiveness of an electronic clinical-decision support tool embedded into the patient medical record at the point of care to guide Mohs surgery utilization: A cohort study.

在护理点嵌入患者病历中的电子临床决策支持工具指导莫氏手术使用的有效性：一项队列研究。

DOI：
10.1016/j.jaad.2021.06.886
发表时间：
2022
期刊：
Journal of the American Academy of Dermatology
影响因子：
13.8
作者：
Ashrafzadeh,Sepideh;Gupta,Sameer;Fiorino,Anne-Maria;Cafiero-Fonseca,ElizabethT;Ferris,TimothyG;Asgari,MaryamM
通讯作者：
Asgari,MaryamM

Association between Human Leukocyte Antigen Type and Keratinocyte Carcinoma Risk in Renal Transplant Recipients.