NeuroMAP Phase II - Administrative Core

NeuroMAP 第二阶段 - 管理核心

• 批准号: 10711135
• 负责人: MARTIN P. PAULUS
• 金额: $ 65.18万
• 依托单位: LAUREATE INSTITUTE FOR BRAIN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-07-01 至 2028-06-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10711135
• 关键词: Address; Advisory Committees; Anxiety Disorders; Applications Grants; Award; Behavior; Biological; Brain; Budgets; Clinical assessments; Communities; Competence; Complex; Consultations; Data; Data Analyses; Development; Eligibility Determination; Ensure; Environment; Evaluation; Faculty; Feedback; Fostering; Foundations; Funding; Future; Genetic; Grant; Human Resources; Infrastructure; Institution; Institutional Review Boards; Laboratories; Leadership; Measures; Mental Health; Mentors; Mentorship; Modeling; Mood Disorders; Neurosciences; Oklahoma; Outcome; Persons; Phase; Pilot Projects; Process; Program Development; Questionnaires; Research; Research Infrastructure; Research Personnel; Research Project Grants; Research Support; Resources; Risk; Robin bird; Standardization; Structure; Suggestion; Supervision; Talents; Testing; Thinking; Time Management; Training; Travel; United States National Institutes of Health; Universities; Update; Visit; Work; base; blood-based biomarker; career; career development; computerized data processing; effectiveness research; experience; health assessment; improved; infrastructure development; meetings; neuroimaging; operation; organizational structure; programs; recruit; response; success; supportive environment; training opportunity; virtual

PROJECT SUMMARY: Administrative Core The Administrative Core for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) CoBRE will continue to provide the following specific aims: (1) infrastructure for programmatic development and oversight; (2) an integrated training and mentoring plan for Research Project Leaders (RPLs); (3) operational support of RPL and Pilot Project Investigator (PPI) day-to-day operations; and (4) management of the Pilot Project program. The basic premise of NeuroMAP Administrative Core is that a supportive framework is necessary to create a strong, interdisciplinary, translational team of junior investigators to transition to R- level competitive researchers. NeuroMAP Phase I Administrative Core accomplishments facilitated by the strategic/scientific oversight of the Leadership Team and Advisory Committee (AC) include: (1) the foundation of a supportive base and training platform for five RPLs during Years 1-3, three RPLs during Years 4-5, and eight PPIs; (2) successful matching of External Mentors with extensive R01-level funding experience to RPLs to facilitate career development; (3) four funded R01s by NeuroMAP investigators (two RPLs and two PPIs) and 14 grant applications submitted by PPIs; (4) active integration of NeuroMAP into the local academic community via participation from Oklahoma State University, University of Oklahoma, and University of Tulsa faculty; and (5) successful recruitment of junior investigators to apply for Pilot Projects. During Phase I, the AC made various suggestions to improve NeuroMAP Phase II, which included: (1) tighter focus on grants that can be applied for based on RPL data; (2) increased statistical consultation; (3) expanding biological assessments beyond neuroimaging; (4) consideration of local mentors for RPLs and PPIs. As a result, Phase II adds the following infrastructure developments: (1) past NeuroMAP RPLs and PPIs who earned R01-level funding will now serve as Internal Mentors to current RPLs; (2) availability of Phase I NeuroMAP multilevel Core data (neuroimaging, behavior, questionnaires, clinical assessments) for new Pilot Projects, thereby facilitating hypothesis testing for future R01 grant applications; (3) successful recruitment of Dr. Wesley Thompson, a statistician with a successful track record of R01-level funding who will guide RPLs and PPIs in data analysis planning/execution; and (4) expansion of training opportunities to include research involving blood-based biomarker and genetic data processing and analysis. Accomplishing these aims of the Administrative Core will extend the critical mass of independent investigators necessary for the theme of NeuroMAP to continue to receive NIH funding and identify new treatment targets to reduce the personal, financial and societal burden of mood and anxiety disorders.

项目摘要：行政核心 基于神经科学的心理健康评估和预测的行政核心（NeuroMap） COBRE将继续提供以下具体目标：（1）编程开发基础架构 和监督； （2）研究项目领导者的综合培训和指导计划（RPLS）； （3） RPL和试点项目调查员（PPI）日常运营的运营支持； （4）管理 试点项目计划。 NeuroMap管理核心的基本前提是一个支持性框架 建立一个强大，跨学科的，转化的初级调查员团队是必要的，以过渡到R- 水平竞争性研究人员。神经局I期行政核心成就促进了 领导团队和咨询委员会（AC）的战略/科学监督包括：（1）基金会 在1 - 3年内为五个RPLs的支持基础和培训平台，在4 - 5年内三个RPL和 八个PPI； （2）与R01级资金经验与RPLS的大量R01的成功匹配 促进职业发展； （3）神经瘤研究者资助的四个R01（两个RPL和两个PPI） 和PPI提交的14个赠款申请； （4）主动整合神经图 通过俄克拉荷马州立大学，俄克拉荷马大学和塔尔萨大学参与的社区 学院; （5）成功招募初级调查人员以申请试点项目。在第一阶段，交流 提出各种建议以改善II阶段的神经瘤 根据RPL数据应用； （2）增加统计咨询； （3）扩大生物学评估 超越神经影像； （4）考虑RPLS和PPI的本地导师。结果，第二阶段添加了 遵循基础设施的发展：（1）获得R01级资金的过去的NeuroMap RPL和PPI将会 现在是当前RPL的内部导师； （2）I阶段神经图多级核心数据的可用性 （神经影像学，行为，问卷，临床评估）新试点项目，从而促进 未来R01赠款申请的假设测试； （3）成功招募卫斯理·汤普森博士 R01级资金的成功记录的统计学家将指导RPLS和PPI在数据分析中 计划/执行； （4）扩大培训机会，包括研究涉及血液的研究 生物标志物和遗传数据处理和分析。完成行政核心的这些目标将 扩展神经瘤主题所必需的独立研究人员的关键质量继续 获得NIH资金并确定新的治疗目标，以减轻个人，财务和社会负担 情绪和焦虑症。