The Center for Neuroscience-based Mental Health Assessment and Prediction (NEUROMAP)

基于神经科学的心理健康评估和预测中心 (NEUROMAP)

• 批准号: 10002251
• 负责人: MARTIN P. PAULUS
• 金额: $ 222.04万
• 依托单位: LAUREATE INSTITUTE FOR BRAIN RESEARCH
• 依托单位国家: 美国
• 财政年份: 2017
• 资助国家: 美国
• 起止时间: 2017-09-15 至 2022-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10002251
• 关键词: Address; Affect; Aftercare; Anorexia Nervosa; Anxiety; Anxiety Disorders; Award; Base of the Brain; Behavioral; Bioinformatics; Biological; Biological Assay; Biological Markers; Biological Process; Biological Psychiatry; Biological Sciences; Brain; Brain imaging; Cells; Centers of Research Excellence; Chicago; Clinical; Clinics and Hospitals; Complex; Core Facility; Country; Desire for food; Development; Disease; Eating Disorders; Electrocardiogram; Electroencephalography; Exposure to; Extinction (Psychology); Extramural Activities; Functional Magnetic Resonance Imaging; Functional disorder; Funding; Future; Goals; Illinois; Individual; Individual Differences; Inflammatory; Infrastructure; Inpatients; Institutes; Interoception; Laboratories; Machine Learning; Magnetic Resonance Imaging; Major Depressive Disorder; Measures; Mental Depression; Mental Health; Mental disorders; Mentors; Midwestern United States; Mood Disorders; Moods; National Institute of Mental Health; Neuraxis; Neurosciences; Oklahoma; Outcome; Outpatients; Patient Recruitments; Patients; Peer Review; Phase; Pilot Projects; Population; Process; Productivity; Psychiatric therapeutic procedure; Psychiatrist; Psychiatry; Reporting; Research; Research Infrastructure; Research Institute; Research Personnel; Research Project Grants; Risk; Role; Schizophrenia; Signal Transduction; Standardization; Stimulus; Symptoms; Technical Expertise; Techniques; Time; United States National Institutes of Health; Universities; base; brain research; career development; conditioned fear; data warehouse; experimental study; habituation; health assessment; health practice; improved; infrastructure development; innovation; insight; motivated behavior; multidisciplinary; multimodality; neuroimaging; novel diagnostics; outcome prediction; predicting response; predictive modeling; programs; recruit; relating to nervous system; response; statistics; tool

Project Summary Mood and anxiety disorders will account for approximately $16 x 109 lost productivity or 25% of global GDP over the next 20 years. Eating disorders are among the deadliest psychiatric diseases and Anorexia Nervosa is two to three times more deadly than schizophrenia, bipolar and major depressive disorder. The Center for Neuroscience-based Mental Health Assessment and Prediction (NeuroMAP) aims to provide a (a) scientific, (b) operational, and (c) educational infrastructure for innovative neuroscience-based research to use individual differences on several biological levels together with sophisticated statistical approaches to generate clinically meaningful predictions of risk and outcomes for mood, anxiety, and eating disorders. The Laureate Institute for Brain Research (LIBR) in Tulsa, OK, is ideally placed to provide this infrastructure because: (a) LIBR has recruited young investigators with an impressive track record of scientific productivity, (b) LIBR is situated adjacent to the Laureate Psychiatric Clinic and Hospital (LPCH), one of the Midwest's largest psychiatric facilities that provides LIBR with a pipeline for patient recruitment, and (c) LIBR closely collaborates with the University of Tulsa (TU) on computational statistics and University of Oklahoma, Tulsa (OU) on bioassay research. The Specific Aims of NeuroMAP are: (1) To provide a state of the art neuroimaging and laboratory infrastructure to conduct biological experiments with multi-level assessments using core facilities; (2) To provide a mentoring infrastructure to a group of young investigators to conduct studies that identify predictive biological markers and processes for patients with mood or anxiety disorders; (3) To create a career development infrastructure to accelerate the investigator's transition from young investigator to established investigator; (4) To build an operational infrastructure that provides the tools necessary to conduct the research projects, standardize assessments and provide a data repository for future pilot projects. NeuroMAP will consists of: (a) an Administrative Core (Paulus): to establish the infrastructure necessary to expand the research efforts of the young investigators; (b) Research Core (Bodurka, Teague, McKinney): to provide the technical expertise to utilize multi-level approaches (from cell markers to symptoms) to quantify individual differences and generate outcome predictions. The Center proposes 5 different projects: (1) Cerebellar Role In Fear Conditioning And Extinction. (Cha) Mentor: Amit Etkin, Stanford; (2) Predicting Response To Exposure Therapy In Anxiety Disorders Using Neural And Behavioral Markers Of Interoceptive Habituation (Feinstein) Mentor: Murray Stein, UCSD; (3) Interoceptive dysfunction and Appetite Dysregulation in Depression (Simmons) Mentor: Luan Phan, University of Illinois Chicago; (4) Response To Inflammatory Challenge In Major Depressive Disorder (Savitz) Mentor: Mike Irwin, UCLA; (5) Dysfunctional Interoceptive Accuracy In Anorexia Nervosa, (Khalsa) Mentor: Walt Kaye, UCSD.

项目摘要 情绪和焦虑症将占损失$ 16 x 109的生产率或全球GDP的25％ 在接下来的20年中。饮食失调是最致命的精神病和神经性厌食症之一 比精神分裂症，双极和重度抑郁症的致命性是致命的两到三倍。中心 基于神经科学的心理健康评估和预测（NEUROMAP）旨在提供（a）科学， （b）运营和（c）基于神经科学的创新研究的教育基础设施，用于使用个人 几个生物学水平的差异以及复杂的统计方法以生成临床 对情绪，焦虑和饮食失调的风险和结果的有意义的预测。获奖研究所 良好的塔尔萨（Tulsa）的大脑研究（Libr）是提供此基础设施的理想位置，因为：（a）libr有 招募了具有令人印象深刻的科学生产率记录的年轻调查员，（b）位置 毗邻获奖者精神病诊所和医院（LPCH），这是中西部最大的精神病学之一 提供Libr提供患者招聘管道的设施，（c）Libr与该设施密切合作 塔尔萨大学（TU）计算统计学和俄克拉荷马大学塔尔萨大学（OU）（OU）生物测定 研究。 NeuroMap的具体目的是：（1）提供神经影像学和实验室的状态 使用核心设施进行多层评估进行生物学实验的基础设施； （2）至 向一群年轻研究人员提供指导基础设施，以进行识别预测性的研究 患有情绪或焦虑症患者的生物标记和过程； （3）创造职业 开发基础设施，以加速研究人员从年轻研究者到建立的过渡 研究者; （4）建立一个运营基础设施，以提供进行研究所需的工具 项目，标准化评估并为未来的试点项目提供数据存储库。神经瘤将 由：（a）行政核心（Paulus）：建立扩展所需的基础架构 年轻研究人员的研究工作； （b）研究核心（Bodurka，Teague，McKinney）：提供 使用多层次方法（从细胞标记到症状）来量化个人的技术专长 差异并产生结果预测。该中心提出了5个不同的项目：（1）小脑角色 在恐惧条件和灭绝中。 （CHA）导师：斯坦福大学的阿米特·埃特金（Amit Etkin）； （2）预测对暴露的反应 使用互感习惯的神经和行为标记（Feinstein）治疗焦虑症治疗（Feinstein） 导师：UCSD的Murray Stein； （3）抑郁症的感受性功能障碍和食欲失调 （西蒙斯）导师：伊利诺伊大学芝加哥大学卢安·潘（Luan Phan）； （4）对炎症挑战的反应 重度抑郁症（Savitz）导师：加州大学洛杉矶分校的Mike Irwin； （5）功能失调的互感精度 神经性厌食症（Khalsa）导师：沃尔特·凯（Walt Kaye），UCSD。