ERC Einstein Rockefeller CUNY Center for AIDS Research

ERC 爱因斯坦洛克菲勒纽约市立大学艾滋病研究中心

基本信息

批准号：
10458265
负责人：
Vilma Gabbay
金额：
$ 4.16万
依托单位：
ALBERT EINSTEIN COLLEGE OF MEDICINE
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-05-01 至 2027-04-30
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10458265
关键词：
AIDS/HIV problem Acquired Immunodeficiency Syndrome Address Anxiety Area Behavioral Biological Markers Brain Caring Clinical Code Cognition Collaborations Communities Data Databases Depressive disorder Diagnosis Diagnostic Enrollment Epidemic Epidemiology Fostering Funding Future Goals Group Meetings HIV HIV therapy Health Health system Immunologics Immunology Inflammation Institutes Institution Interdisciplinary Study Intervention Investigation Knowledge Lead Mental Depression Mental Health Mental disorders Mission National Institute of Drug Abuse National Institute of Mental Health Neurology New York City Outcome Pain Pathway interactions Persons Prevalence Public Health Research Research Personnel Research Project Grants Resources Risk Substance Use Disorder Technology Translational Research Universities Work addiction antiretroviral therapy base burden of illness cognitive neuroscience cohort comorbidity depressive symptoms experience health disparity implementation science improved interdisciplinary approach interdisciplinary collaboration member multidisciplinary neural circuit neurochemistry neuroimaging neuroinflammation neuropsychiatry novel pre-clinical psychiatric comorbidity recruit substance use transmission process working group

项目摘要

PROJECT SUMMARY ERC-CFAR: HIV AND MENTAL HEALTH SCIENTIFIC WORKING GROUP The newly formed HIV and Mental Health Scientific Working Group (SWG) aims to facilitate multi-disciplinary investigations in the field of HIV and mental health comorbidity, a major public health concern, contributing to increased HIV transmission, and an undeveloped area of research in our ERC-CFAR. While dramatic survival gains have been achieved for people with HIV (PWH) with the widespread use of potent antiretroviral therapy (ART), high comorbidity with mental health conditions such as depression has posed a major barrier to achieving the 90-90-90 goal and “bending the curve.” National data estimate that comorbid mental health conditions impact the majority of PWH, leading to increased HIV transmission risk, reduced retention in care, and poorer HIV outcomes. Alarmingly, by 2030, the top two leading causes of disease burden globally are projected to be HIV and depressive disorders. Despite these data, there has been sparse research into the mechanisms underlying this comorbidity. This SWG addresses this major gap in HIV research with the overall mission of seeding and catalyzing research that impacts mental health in PWH to reduce HIV transmission and acquisition, and to improve retention in care and overall outcomes. Toward this goal, this SWG brings together with community members >30 non-HIV and HIV researchers with diverse expertise in immunology, neuroimaging, neurology, cognitive neuroscience, epidemiology, health disparities, and addiction, recruited from multiple New York City academic institutions. Specific Aims: 1) To bring together outstanding HIV and non-HIV investigators from multidisciplinary research areas and multiple NYC Institutions to foster collaborations in the field of mental health in PWH, focusing on psychiatric neuroimaging, neuroinflammation, and implementation science. 2) To generate new interdisciplinary collaborations among established investigators (EI) and Early Stage Investigators (ESI) who work on HIV research but have not previously collaborated, as well as with investigators who are new to HIV research. 3) To identify and seek funding for research projects developed through collaborations and ideas formed in the SWG to increase our understanding of the underlying mechanisms contributing to the high burden of mental health conditions among PWH, including depression, anxiety, cognition, and pain. Comorbid mental health conditions in PWH are a major public health concern and an obstacle to stopping the HIV epidemic partly due to increased transmission risk and decreased retention in care. To date, this topic has attracted limited research. This SWG aims to fill this research gap and facilitate research into the mechanisms underlying this comorbidity and how best to treat it. Such research is essential for ending the HIV epidemic.

项目概要 ERC-CFAR：艾滋病毒和心理健康科学工作组新成立的艾滋病毒和心理健康科学工作组（SWG）旨在促进多学科研究艾滋病毒和心理健康合并症领域的调查是一个主要的公共卫生问题，有助于 HIV 传播增加，并且我们的 ERC-CFAR 研究领域尚未开发，而存活率却很高。随着有效抗逆转录病毒疗法的广泛使用，艾滋病毒感染者 (PWH) 已取得了进展（ART），与抑郁症等精神健康状况的高度共病已成为实现目标的主要障碍 90-90-90 目标和“弯曲曲线”。国家数据估计，共病心理健康状况会产生影响大多数感染者，导致艾滋病毒传播风险增加、护理保留时间减少以及艾滋病毒感染状况较差令人震惊的是，到 2030 年，全球疾病负担的两大主要原因预计将是艾滋病毒。尽管有这些数据，但对其潜在机制的研究却很少。该 SWG 的总体使命是解决艾滋病毒研究中的这一重大空白。促进影响艾滋病毒感染者心理健康的研究，以减少艾滋病毒传播和获得，并为了实现这一目标，该 SWG 与社区共同努力。成员 > 30 名非 HIV 和 HIV 研究人员，在免疫学、神经影像学、神经病学、认知神经科学、流行病学、健康差异和成瘾，从多个纽约市招募具体目标： 1) 汇集来自各学术机构的杰出艾滋病毒和非艾滋病毒研究人员。多学科研究领域和多个纽约机构促进心理健康领域的合作在 PWH，专注于精神神经影像学、神经炎症和实施科学 2) 生成。成熟研究者 (EI) 和早期研究者 (ESI) 之间新的跨学科合作从事艾滋病毒研究但以前没有合作过的人，以及刚接触艾滋病毒的研究人员 3) 确定通过合作和想法开发的研究项目并寻求资金。在 SWG 中成立，以加深我们对导致高负担的根本机制的理解感染者的心理健康状况，包括抑郁、焦虑、认知和疼痛。艾滋病毒感染者的健康状况是一个主要的公共卫生问题，也是阻止艾滋病毒流行的一个障碍由于传播风险增加和护理保留率下降，迄今为止，这个话题引起的关注有限。该 SWG 旨在填补这一研究空白并促进对其背后机制的研究。合并症以及如何最好地治疗它对于结束艾滋病毒流行至关重要。