7T Magnetic Resonance Imaging System for Basic, Translational and Clinical Research

用于基础、转化和临床研究的 7T 磁共振成像系统

• 批准号: 9940405
• 负责人: Yi Wang
• 金额: $ 200万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-04-01 至 2024-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9940405
• 关键词: Basic Science; Biomedical Research; Brain; Clinical; Clinical Research; Degenerative polyarthritis; Disease; Disease Progression; Epilepsy; Goals; Grant; Human; Image; Inflammatory; Infrastructure; Investments; Magnetic Resonance Imaging; Magnetism; Malignant Neoplasms; Medicine; Mental disorders; Nerve Degeneration; Noise; Organ; Pathology; Research; Signal Transduction; Stroke; Tissues; Translational Research; Universities; Vascular Diseases; clinical practice; cost; imaging study; imaging system; instrument; instrumentation; medical schools; programs; response; tool

PROJECT SUMMARY Weill Medical College of Cornell University (Weill Cornell Medicine, WCM) requests High-End Instrumentation Grant Program support to purchase a state-of-the-art human whole-body seven Tesla (7T) magnetic resonance imaging (MRI) system as a Special Use Instrument (SUI; PAR-19-177). This 7T MRI is part of a major WCM strategic investment in crucial imaging infrastructure needed to advance basic, translational and clinical research. As ultrahigh field 7T offers supreme signal-to-noise ratio (SNR) for MRI studies and supreme signal for tissue magnetism studies, both that increase with MRI field strength, 7T MRI is a vital research tool for our users to study devastating diseases of subtle pathologies in the vital brain and many other organs in the body. We request this SUI 7T MRI of the highest clinically-available field strength for integrated biomedical research and clinical practice, where the clinical practice will help overcome the prohibitive cost of purchasing, installing, operating and maintaining a 7T MRI and, more importantly, will enhance translational and clinical researches that are the foci of most our users. WCM is a world leader on biomedical research, and its long- range goals include catching and curing diseases at their early stages. This SUI 7T MRI, with exquisite tissue sensitivity to detect subtle changes at early stage of disease progression and therapy response, will contribute significantly to our quest in understanding and treating various diseases, including neurodegeneration, psychiatric disorders, epilepsy, stroke, osteoarthritis, inflammatory diseases, cancers, and vascular diseases.

项目概要 康奈尔大学威尔医学院（Weill Cornell Medicine，WCM）请求高端仪器 拨款计划支持购买最先进的人体全身七特斯拉（7T）磁力 磁共振成像（MRI）系统作为特殊用途仪器（SUI；PAR-19-177）。该 7T MRI 是 WCM 对关键成像基础设施进行重大战略投资，以推进基础、转化和 临床研究。由于超高场 7T 为 MRI 研究提供了最高的信噪比 (SNR)，并且 用于组织磁性研究的信号，两者均随 MRI 场强而增加，7T MRI 是重要的研究工具 供我们的用户研究重要大脑和许多其他器官中微妙病理的毁灭性疾病 身体。我们要求 SUI 7T MRI 具有临床可用的最高场强，用于综合生物医学 研究和临床实践，临床实践将有助于克服高昂的购买成本， 安装、操作和维护 7T MRI，更重要的是，将增强转化和临床 我们大多数用户关注的焦点的研究。 WCM 是生物医学研究领域的世界领先者，其长期 范围目标包括在疾病的早期阶段发现并治愈疾病。这台SUI 7T MRI，组织细腻 在疾病进展和治疗反应的早期阶段检测细微变化的敏感性将有助于 对我们理解和治疗各种疾病（包括神经退行性疾病）的探索具有重要意义， 精神疾病、癫痫、中风、骨关节炎、炎症性疾病、癌症和血管疾病。