Multiple Sclerosis Lesion Magnetic Susceptibility Activity

多发性硬化症病变磁化率活性

• 批准号: 9922392
• 负责人: Yi Wang
• 金额: $ 36.74万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9922392
• 关键词: Accounting; Address; Age; Autopsy; Back; Biological Markers; Blood - brain barrier anatomy; Brain; Chronic; Cicatrix; Confusion; Data; Demyelinations; Deposition; Development; Diagnosis; Disease; Financial compensation; Gadolinium; Goals; Image; Imaging Techniques; Immunohistochemistry; Inflammation; Inflammatory; Iron; Lesion; Longitudinal Studies; Longitudinal prospective study; Macrophage Activation; Magnetic Resonance Imaging; Magnetism; Maps; Measurement; Measures; Methods; Microglia; Modeling; Monitor; Motion; Multiple Sclerosis; Multiple Sclerosis Lesions; Myelin; Nerve Degeneration; Neurologic Deficit; Outcomes Research; Pathogenicity; Pathologic; Patients; Phase; Play; Predisposition; Process; Property; Reference Standards; Reproducibility; Research; Research Project Grants; Resolution; Retrospective Studies; Role; Scanning; Signal Transduction; Source; Specificity; Specimen; Structure; Techniques; Testing; Time; Tissue Sample; Tissues; base; blood-brain barrier disruption; clinical practice; data acquisition; healing; imaging biomarker; improved; interest; multiple sclerosis patient; prevent; public health relevance; recruit; remyelination; spatiotemporal; tool; white matter

 DESCRIPTION (provided by applicant): The long term objective of this project is to improve the capability to monitor the inflammatory and neurodegenerative processes in Multiple Sclerosis (MS) for effective diagnosis and treatment. The specific goal of this research is to establish the time course of magnetic susceptibility of lesions as a sensitive probe of demyelination and iron content associated with inflammatory processes. Currently, gadolinium enhancement in conventional magnetic resonance imaging (MRI) is widely used to map inflammation caused by blood brain barrier (BBB) disruption during MS lesion formation. However, there is still inflammation in the brain after the BBB heals and currently there is no method in clinical practice to detect this inflammation behind the BBB. Our preliminary data demonstrates that the time course of lesion magnetic susceptibility as measured by quantitative susceptibility mapping (QSM) can detect lesion activity after the resolution of gadolinium enhancement. Accordingly, this proposed research will try to establish the existence of and gain a basic understanding of the time course of MS lesion susceptibility by carrying out three specific aims: Aim 1: Improve QSM scanning robustness and processing accuracy for reliable longitudinal measurement of susceptibility time course. We hypothesize that QSM can be improved to high reproducibility and accuracy of 0.01ppm (parts per million, susceptibility unit). Aim 2: Define the MS lesion magnetic susceptibility time course through prospective longitudinal study of the susceptibility of lesions at all ages, with spatiotemporal correlation of gadolinium enhancement measured by conventional MRI. We hypothesize that lesion susceptibility changes dynamically over time, even after inflammatory activity, as measured by conventional MRI, has subsided. Aim 3: Define the immunohistochemical correlates of MS lesion magnetic susceptibility using autopsied brain specimens from MS patients and controls. We hypothesize that the QSM signal of an MS lesion correlates in part with microglia/macrophages activation (i.e. inflammatory activity) and that the QSM value of a fully demyelinated lesion is determined by iron.

 描述（由申请人提供）：该项目的长期目标是提高监测多发性硬化症（MS）炎症和神经退行性过程的能力，以进行有效的诊断和治疗。该研究的具体目标是确定时间进程。目前，传统磁共振成像（MRI）中的钆增强广泛用于绘制血脑屏障（BBB）引起的炎症图谱。然而，在 BBB 愈合后，大脑中仍然存在炎症，目前临床实践中没有方法检测 BBB 后面的这种炎症，我们的初步数据表明，测量的病变磁化率的时间进程。通过磁化率图（QSM）可以检测钆增强分辨率后的病变活动。因此，本项定量研究将尝试通过实现三个具体目标来确定 MS 病变磁化率的存在并获得对 MS 病变磁化率的时间过程的基本了解：目标 1：提高 QSM 扫描稳健性和处理精度，以实现磁敏度时间过程的可靠纵向测量。我们发现 QSM 可以提高到 0.01ppm（百万分之一，磁敏度单位）的高再现性和精度。 目标 2：定义 MS 病变。通过对所有年龄段病变的磁化率进行前瞻性纵向研究，利用传统 MRI 测量的钆增强的时空相关性，得出磁化率时间进程。即使在传统 MRI 测量的炎症活动消退后，病变敏感性也会随着时间动态变化。 目标 3：使用来自 MS 患者和对照的尸检脑标本来定义 MS 病变磁敏感性的免疫组织化学相关性。 MS 病变部分与小胶质细胞/巨噬细胞激活（即炎症活动）相关，并且完全脱髓鞘病变的 QSM 值由铁决定。

项目成果

Diagnostic accuracy of semiautomatic lesion detection plus quantitative susceptibility mapping in the identification of new and enhancing multiple sclerosis lesions.

半自动病变检测加上定量磁敏图在识别新的和增强的多发性硬化症病变中的诊断准确性。

• 发表时间: 2018
• 作者: Zhang, Shun;Nguyen, Thanh D;Zhao, Yize;Gauthier, Susan A;Wang, Yi;Gupta, Ajay
• 通讯作者: Gupta, Ajay

Fast and Robust Unsupervised Identification of MS Lesion Change Using the Statistical Detection of Changes Algorithm.

使用变化统计检测算法快速、稳健地无监督识别 MS 病变变化。

• 发表时间: 2018-05
• 作者: Nguyen, T D;Zhang, S;Gupta, A;Zhao, Y;Gauthier, S A;Wang, Y
• 通讯作者: Wang, Y

MRI based texture analysis to classify low grade gliomas into astrocytoma and 1p/19q codeleted oligodendroglioma.

基于 MRI 的纹理分析将低级别胶质瘤分类为星形细胞瘤和 1p/19q 共缺失少突胶质细胞瘤。

• DOI: 10.1016/j.mri.2018.11.008
• 发表时间: 2019-04-01
• 期刊: Magnetic resonance imaging
• 影响因子: 2.5
• 作者: Shun Zhang;G. Chiang;R. Magge;H. Fine;R. Ramakrishna;E. Chang;Tejas Pulisetty;Yi Wang;Wenzhe
• 通讯作者: Wenzhe

Subsecond accurate myelin water fraction reconstruction from FAST-T2 data with 3D UNET.

使用 3D UNET 根据 FAST-T2 数据进行亚秒级准确的髓磷脂水分数重建。

• 发表时间: 2022-06
• 影响因子: 3.3
• 作者: Kim, Jeremy;Nguyen, Thanh D;Zhang, Jinwei;Gauthier, Susan A;Marcille, Melanie;Zhang, Hang;Cho, Junghun;Spincemaille, Pascal;Wang, Yi
• 通讯作者: Wang, Yi

Grading meningiomas utilizing multiparametric MRI with inclusion of susceptibility weighted imaging and quantitative susceptibility mapping.

利用多参数 MRI 对脑膜瘤进行分级，包括磁敏感加权成像和定量磁敏感图。

• DOI: 10.1016/j.neurad.2019.05.002
• 发表时间: 2020-06-01
• 期刊: Journal of neuroradiology. Journal de neuroradiologie
• 作者: Shun Zhang;G. Chiang;J. Knapp;C. Zecca;D. He;R. Ramakrishna;R. Magge;D. Pisapia;H. Fine
• 通讯作者: H. Fine