Computational and mathematical modeling of biomedical systems

生物医学系统的计算和数学建模

• 批准号: 10408143
• 负责人: Timothy W. Secomb
• 金额: $ 41.63万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-01 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10408143
• 关键词: Computer Models; System; mathematical model

This program prepares scientists for research careers in the computational and mathematical modeling of medically significant biological systems through interdisciplinary training at the predoctoral level. Noted for its well-established system of interdisciplinary graduate programs and for its tradition of collaborations across departmental boundaries, the University of Arizona provides a highly suitable environment for such training. Fifteen training faculty with appointments in multiple departments and interdisciplinary graduate programs provide strength in five broad areas: bioinformatics; molecular dynamics; cellular processes; physiology and pathophysiology; biostatistics and stochastic processes. Students will be drawn from multiple graduate programs in mathematical and life sciences, including the programs in Applied Mathematics and in Biochemistry and Molecular & Cellular Biology. In most cases, students will receive two years of support from this program, starting in their second or third year of graduate training. Trainees will pursue the coursework requirements of their own graduate programs and, in addition, take graduate courses in mathematical modeling and in bioinformatics, which are tailored to the trainees' needs and take into account their diverse scientific backgrounds. All trainees will take part in a weekly Quantitative Biology Colloquium that has been running continuously for more than twenty years. This colloquium includes presentations by students, faculty and visiting speakers, and promotes dialog between trainees and faculty with primarily mathematical or computational backgrounds and those with strong biological training. It will include components explicitly devoted to training in responsible conduct of research, methods for enhancing reproducibility, and career development including preparation for a range of careers in biomedical research. Trainees will carry out their doctoral research with advisors whose research, whether theoretical or experimental, emphasizes application of theoretical approaches to biomedical problems. Trainees participating in this program will not only receive research training in relevant areas, but, equally importantly, will develop the ability to communicate and collaborate across traditional disciplinary boundaries and to work with researchers with complementary expertise. Researchers with such skills are critically needed in many areas of biomedical science in which sophisticated theoretical approaches are necessary in order to achieve further progress.

该计划为科学家准备了计算和数学的研究职业 通过跨学科培训在医学上重要的生物系统建模 占主导地位。以其公认的跨学科研究生课程制度而闻名 以及其在亚利桑那大学跨部界限的传统 为此类培训提供了非常合适的环境。 15个培训教师 多个部门和跨学科研究生课程的任命提供了力量 在五个广泛的领域：生物信息学；分子动力学；细胞过程；生理学和 病理生理学；生物统计学和随机过程。学生将从多个 数学和生命科学的研究生课程，包括应用程序 数学以及生物化学以及分子和细胞生物学。在大多数情况下，学生将 从该计划获得两年的支持，从他们的第二年或第三年开始 训练。受训人员将追求自己的研究生课程的课程要求，并 此外，参加数学建模和生物信息学领域的研究生课程， 根据受训者的需求量身定制，并考虑到他们多样化的科学背景。全部 学员将参加一直在运行的每周定量生物学座谈会 连续二十年。该座谈会包括学生的演讲， 教师和访客演讲者，并促进学员和教师之间的对话 数学或计算背景以及具有强大生物学训练的人。会 包括明确致力于培训负责任进行研究的组件，方法 提高可重复性和职业发展，包括准备一系列 生物医学研究的职业。学员将与顾问进行博士研究 谁的研究，无论是理论还是实验性，都强调了理论的应用 生物医学问题的方法。参加该计划的学员不仅会接受 相关领域的研究培训，但同样重要的是，将发展 在传统的学科边界上进行交流和协作并与之合作 具有互补专业知识的研究人员。具有此类技能的研究人员至关重要 生物医学科学的许多领域是必须采用复杂理论方法的领域 为了取得进一步的进步。