Computational and Mathematical Modeling of Biomedical Systems

生物医学系统的计算和数学建模

• 批准号: 9059103
• 负责人: Timothy W. Secomb
• 金额: $ 23.02万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9059103
• 关键词: Computer Simulation; System; mathematical model

DESCRIPTION (provided by applicant): This program prepares scientists for research careers in the computational and mathematical modeling of medically significant biological systems through interdisciplinary training at the predoctoral level. Noted for its well-established system f interdisciplinary graduate programs and for its tradition of collaborations across departmental boundaries, the University of Arizona provides a highly suitable environment for such training. Eighteen training faculty and three associate faculty with appointments in multiple departments and interdisciplinary graduate programs provide strength in five broad areas: bioinformatics; molecular dynamics; cellular processes; physiology and pathophysiology; biostatistics and stochastic processes. Students are drawn from multiple graduate programs in mathematical and life sciences, including the interdisciplinary Graduate Program in Applied Mathematics. In most cases, students receive two years of support from this program, starting in their second or third year of graduate training. Trainees pursue the coursework requirements of their own graduate programs and, in addition, take graduate courses in mathematical modeling and in bioinformatics, which are tailored to the trainees' needs and take into account their diverse scientific backgrounds. All trainees take part in a weekly biomathematics colloquium that has been running continuously for more than fifteen years. This colloquium includes presentations by students, faculty and visiting speakers, and promotes dialog between trainees and faculty with primarily mathematical or computational backgrounds and those with strong biological training. Trainees carry out their doctoral research with advisors whose research, whether theoretical or experimental, emphasizes application of theoretical approaches to biomedical problems. Where appropriate, a co-advisor is appointed to provide complementary expertise to that of the primary advisor. Trainees participating in this program not only receive research training in relevant areas, but, equally importantly, develop the ability to communicate and collaborate across traditional disciplinary boundaries and to work with researchers with complementary expertise. Researchers with such skills are critically needed in many areas of biomedical science in which sophisticated theoretical approaches are necessary in order to achieve further progress.

描述（由申请人提供）：该计划通过跨学科的跨学科培训在计算和数学建模中为科学家准备研究职业。亚利桑那大学（University of Arizona）以其公认的系统F跨学科研究生课程及其在部门边界的合作传统而闻名，为这种培训提供了一个非常合适的环境。十八位培训教师和三个在多个部门任命和跨学科研究生课程的副教授在五个广泛领域提供了力量：生物信息学；分子动力学；细胞过程；生理学和病理生理学；生物统计学和随机过程。学生来自数学和生命科学的多个研究生课程，包括应用数学的跨学科研究生课程。在大多数情况下，从研究生培训的第二年或第三年开始，学生会获得该计划的两年支持。受训人员追求自己的研究生课程的课程要求，此外，还参加了数学建模和生物信息学领域的研究生课程，这些课程是根据受训者的需求量身定制的，并考虑了他们多样化的科学背景。所有受训者都参加了每周的生物学座谈会，该座谈会一直在不断运行超过15年。该座谈会包括学生，教职员工和访客演讲者的演讲，并促进具有数学或计算背景的学员和教职员工之间的对话，以及具有强大生物学培训的对话。学员与顾问进行博士研究，他们的研究（无论是理论还是实验性）强调了理论方法在生物医学问题上的应用。在适当的情况下，任命一个共同顾问为主要顾问提供补充专业知识。参加该计划的学员不仅接受了相关领域的研究培训，而且同样重要的是，可以发展在传统的纪律界限上进行交流和协作的能力，并与具有互补专业知识的研究人员合作。在生物医学科学的许多领域，必须进行此类技能的研究人员，在这些领域中，必须采用复杂的理论方法来取得进一步的进步。