Computational and Mathematical Modeling of Biomedical Systems

生物医学系统的计算和数学建模

• 批准号: 9059103
• 负责人: Timothy W. Secomb
• 金额: $ 23.02万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-07-01 至 2019-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9059103
• 关键词: Computer Simulation; System; mathematical model

DESCRIPTION (provided by applicant): This program prepares scientists for research careers in the computational and mathematical modeling of medically significant biological systems through interdisciplinary training at the predoctoral level. Noted for its well-established system f interdisciplinary graduate programs and for its tradition of collaborations across departmental boundaries, the University of Arizona provides a highly suitable environment for such training. Eighteen training faculty and three associate faculty with appointments in multiple departments and interdisciplinary graduate programs provide strength in five broad areas: bioinformatics; molecular dynamics; cellular processes; physiology and pathophysiology; biostatistics and stochastic processes. Students are drawn from multiple graduate programs in mathematical and life sciences, including the interdisciplinary Graduate Program in Applied Mathematics. In most cases, students receive two years of support from this program, starting in their second or third year of graduate training. Trainees pursue the coursework requirements of their own graduate programs and, in addition, take graduate courses in mathematical modeling and in bioinformatics, which are tailored to the trainees' needs and take into account their diverse scientific backgrounds. All trainees take part in a weekly biomathematics colloquium that has been running continuously for more than fifteen years. This colloquium includes presentations by students, faculty and visiting speakers, and promotes dialog between trainees and faculty with primarily mathematical or computational backgrounds and those with strong biological training. Trainees carry out their doctoral research with advisors whose research, whether theoretical or experimental, emphasizes application of theoretical approaches to biomedical problems. Where appropriate, a co-advisor is appointed to provide complementary expertise to that of the primary advisor. Trainees participating in this program not only receive research training in relevant areas, but, equally importantly, develop the ability to communicate and collaborate across traditional disciplinary boundaries and to work with researchers with complementary expertise. Researchers with such skills are critically needed in many areas of biomedical science in which sophisticated theoretical approaches are necessary in order to achieve further progress.

描述（由申请人提供）：该项目通过博士前水平的跨学科培训，为科学家在具有医学意义的生物系统的计算和数学建模方面的研究生涯做好准备。亚利桑那大学以其完善的跨学科研究生课程体系和跨部门合作的传统而闻名，为此类培训提供了非常合适的环境。十八名培训教师和三名副教师在多个部门和跨学科研究生项目中任职，在五个广泛领域提供优势：生物信息学；分子动力学；细胞过程；生理学和病理生理学；生物统计学和随机过程。学生来自数学和生命科学领域的多个研究生课程，包括应用数学跨学科研究生课程。在大多数情况下，学生从研究生培训的第二年或第三年开始，从该计划中获得两年的支持。学员不仅要完成自己研究生课程的课程要求，还要学习数学建模和生物信息学方面的研究生课程，这些课程是根据学员的需求量身定制的，并考虑到了学员不同的科学背景。所有学员每周都会参加生物数学座谈会，该座谈会已经连续举办了十五年多。这次研讨会包括学生、教师和客座演讲者的演讲，并促进主要具有数学或计算背景以及受过严格生物学训练的学员和教师之间的对话。学员与导师一起进行博士研究，导师的研究，无论是理论还是实验，都强调将理论方法应用于生物医学问题。在适当的情况下，指定一名联合顾问为主要顾问提供补充专业知识。参加该项目的学员不仅接受相关领域的研究培训，同样重要的是，培养跨传统学科界限沟通和协作的能力，以及与具有互补专业知识的研究人员合作的能力。生物医学科学的许多领域都迫切需要具有此类技能的研究人员，在这些领域中，需要复杂的理论方法才能取得进一步的进展。