Tissue microenvironment (TIMe) training program

组织微环境（TIMe）培训计划

• 批准号: 10207105
• 负责人: Rohit Bhargava
• 金额: $ 16.43万
• 依托单位: UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-04-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10207105
• 关键词: Tissues; Training Programs

Project Summary/Abstract A quantitative understanding of the tissue microenvironment (TiMe) is critical for advancing biomedical knowledge and healthcare, ranging from regenerative medicine to managing the burden of cancer. To train productive scientific leaders, education in three technological areas is essential: (a) sensing and imaging to measure biochemical and biophysical properties, (b) bioengineering to recapitulate the TiMe, and (c) computational modeling and analytics to gain insight. Accordingly, we propose to continue the TiMe training program wherein predoctoral students integrate the three technological approaches with TiMe-related biological contexts of disease and development to launch successful research careers. Training includes four core components—Curricular Activities to ensure technical depth and critical thinking with apposite breadth across disciplines, Extracurricular Activities to develop pragmatic skills, Professional Development to empower trainees to become research leaders, and Career Development to position trainees to make lifelong contributions to society. The activities are structured to streamline education and efficient focus on research with the awarded doctoral degree to include a special designation (concentration in TiMe). This past project period was our first and progress was made in establishing the program, its activities and evaluation to refine it further. Building upon the success of trainees (all ten graduated are in biomedical research careers, ~5.5. papers per trainee, and significant follow-on funding and awards), we propose to continue student development activities, add a novel hands-on education component based on a newly constructed laboratory and emphasize emerging scientific topics including machine learning and design thinking. Illinois has exceptionally strong disciplinary programs, diverse faculty spanning the program, appropriate facilities and unique resources in each of these technological areas. The TiMe Training Program is distinctly advantaged by our strong history of successful graduate training, including a commitment to diversity and individuals with disabilities, a culture of productive collaboration, a new Department of Bioengineering, and strong institutional support (matching direct support - $1.5 M and $2.9 M of total support). Forty faculty will serve as faculty mentors and another four, with expertise in pedagogy, evaluation and professional development, provide critical resources for the program. We propose to educate at least twelve trainees (six from NIH support and six matching slots from Institutional support) for up to two years each. Six trainees will be appointed annually from a strong applicant pool across campus. Traditional education will further be enhanced by co-mentored research with possibilities of translational opportunities via a new engineering- based College of Medicine. Outcomes will be rigorously evaluated throughout the program to improve training, to guide administrative decision-making and to disseminate best practices. The vision, expertise, and infrastructure of the Illinois TiMe Training Program will ensure that trainees selected from a strong and diverse graduate community will provide sustained research contributions to benefit public health.

项目摘要/摘要 对组织微环境（时间）的定量理解对于推进生物医学至关重要 知识和医疗保健，从再生医学到管理癌症的负担。 生产性科学领导者，三个技术领域的教育至关重要：（a）感应和成像 测量生化和生物物理特性，（b）生物工程以重新分配时间，（c） 计算建模和分析以获得洞察力。 节目中学生将技术方法与时间有关的生物学整合 疾病和发展的环境开展了成功的研究职业。 组件 - 繁琐的活动，以确保技术深度和批判性思维，并具有适当的广度 学科，尿外活动以发展务实的技能，专业发展以增强受训者的能力 成为研究领导者和职业发展，以定位受训者，以做出终身贡献 社会的活动是为了简化教育和效率 博士学位包括特殊名称（及时集中）。 在建立该计划，其活动和评估方面取得的进展是进一步的 学员的成功（所有十个毕业的人都在生物医学研究职业中，〜5.5。 大量资金和奖励），我们建议继续学生发展活动，添加一本小说 基于没有新的构建实验室的动手教育组成部分，并强调新兴的科学 包括机器学习和设计思维的主题。 跨越计划的各种教师，适当的设施和独特的资源 时间培训计划是我们成功的研究生培训历史所优势的 将多元化和残疾人的统一置于繁荣的文化，一种新的 生物工程部和强大的研究所支持（匹配直接支持 - $ 1.5 m和2.9 m $ 2.9 m 全部支持）。 和专业发展，为该计划提供关键资源。 最多六年的学员（来自Internital Support的六个匹配插槽）。 传统教育将进一步 通过新工程学的转化机会的可能性，可以增强转化机会的可能性 - 基于医学学院将在整个计划中进行严格评估，以改善培训 指导行政决策并传播最佳实践。 伊利诺伊州时间培训计划的基础设施将确保从强大而多样化的 研究生界提供持续的研究贡献，以使公共卫生受益。