Integrated Small Animal Imaging Research Resource

综合小动物成像研究资源

• 批准号: 10162519
• 负责人: Chin-Tu Chen
• 金额: $ 25.79万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10162519
• 关键词: Adopted; Animal Cancer Model; Animal Technicians; Animals; Biology; Budgets; Cancer Center; Cancer Center Support Grant; Chemistry; Collaborations; Colorectal Cancer; Consultations; Contrast Media; Custom; Cyclotrons; Data Analyses; Detection; Development; Diagnosis; Faculty; Fee-for-Service Plans; Funding; Grant; Head Cancer; Hour; Image; Image Analysis; Imaging Techniques; Imaging technology; Individual; Infrastructure; Institutes; Leadership; Magnetic Resonance Imaging; Malignant neoplasm of brain; Malignant neoplasm of lung; Malignant neoplasm of ovary; Malignant neoplasm of pancreas; Malignant neoplasm of prostate; Manuscripts; Modality; Modeling; Monitor; Multimodal Imaging; Neck Cancer; Organ; Preparation; Protocols documentation; Radiochemistry; Radiolabeled; Research; Research Personnel; Resources; Services; Specific qualifier value; Specimen; Structure; Technical Expertise; Technology; Tissue imaging; Tracer; Training; Training and Education; Ultrasonography; X-Ray Computed Tomography; animal imaging; anticancer research; base; cancer therapy; cost effectiveness; design; ex vivo imaging; experience; experimental study; imaging approach; imaging capabilities; imaging modality; improved; in vivo imaging; instrumentation; malignant breast neoplasm; member; microPET; molecular imaging; optical imaging; outreach; programs; repository; single photon emission computed tomography; spectrograph; spectroscopic imaging; synergism

ABSTRACT Imaging small animal models of cancer has become an essential and integral part of cancer research. The Integrated Small Animal Imaging Research Resource (iSAIRR) has demonstrated its broad usage and applications in advancing research in breast, lung, prostate, ovarian, head and neck, pancreatic, colorectal, and brain cancer. Evolving imaging technologies have also made available different, but complementary, imaging methods for assessing underlying biology and mechanisms, improving diagnosis and detection, and monitoring effects of cancer therapies. To take full advantage of this rapidly changing imaging landscape, and to provide a wider spectrum of imaging capabilities and services, the iSAlRR now offers a broader spectrum of imaging modalities and techniques for in vivo imaging of small animals and ex vivo imaging of tissue/organ specimens with improved operational efficiency and cost effectiveness. The iSAIRR now includes the following Subcores: 1) Magnetic Resonance Imaging and Spectroscopy (MRIS); 2) Optical Imaging (OI); 3) microPET/SPECT/CT imaging, with the image and data analysis components added in this cycle; and 4) Imaging Chemistry. CCSG funds are not requested for the Imaging Chemistry services. The Imaging Chemistry Subcore was established in 2015 using UCCCC Developmental Funds, and brings distinctive capabilities and expertise to our users, including specifically designed contrast agents, and collaborates with the new Cyclotron Facility and developing radiochemistry program enabling unique imaging approaches. During the current funding period, the iSAIRR has been strategically restructured to better support ongoing and future research. Core leadership has been enhanced with new technical directors and an expanded Faculty Oversight Committee representing the changing needs of our users and services of the Core. The Imaging Veterinary Technology Support Subcore was dissolved and a more efficient model has been adopted. Trained veterinary technicians’ effort is distributed across all modalities as needed, with an increased contribution from operators. The 9.4T MRI scanner was recently upgraded, and there are plans to expand the microPET/ SPECT/CT imaging services and capabilities. Going forward, an Ultrasound Imaging Subcore will be established, and available to users with a fee-for-service structure for independent as well as assisted use (no CCSG funds requested). After an internal review and following users’ requests, the image analysis component previously included in the UCCCC Image Computing, Analysis, and Repository Core (ICAR), was incorporated into ISAIRR. More specifically, it has been incorporated into the microPET/SPECT/CT Subcore. Such integration has enhanced the efficiency of this Subcore by providing more organic and inclusive services in molecular imaging.

抽象的 对癌症的小动物模型进行成像已成为癌症研究的重要组成部分。这 集成的小动物成像研究资源（ISAIRR）已证明其广泛的用法和 在乳房，肺，前列腺，卵巢，头颈，胰腺，结直肠肠，卵巢和颈部进行研究方面的应用 和脑癌。不断发展的成像技术也可以提供不同的，但要好， 评估潜在生物学和机制，改善诊断和检测的成像方法，以及 癌症疗法的监测作用。充分利用这种快速变化的成像景观，并 为了提供更广泛的成像功能和服务，ISALRR现在提供了更广泛的范围 小动物体内成像的成像方式和技术和组织/器官的体内成像 标本提高了运营效率和成本效益。 Isairr现在包括以下内容 子核：1）磁共振成像和光谱学（MRIS）； 2）光学成像（OI）； 3）MicroPET/SPECT/CT成像，并在此周期中添加了图像和数据分析组件；和 4）成像化学。不要求CCSG资金用于成像化学服务。成像 化学子核心于2015年使用UCCCC开发基金建立，并带来独特的 对我们的用户的功能和专业知识，包括专门设计的对比代理，并与 新的Cyclotron设施和开发放射化学计划，实现了独特的成像方法。 在当前的资金期间，伊萨尔（Isairr）在战略上已经恢复，以更好地支持正在进行的支持和 未来的研究。核心领导力得到了新的技术主管和扩大的教职员工的增强 监督委员会代表我们用户和核心服务的需求不断变化的委员会。成像 兽医技术支持子核被解散，并采用了更有效的模型。训练有素 兽医技术的努力根据需要在所有方式上分配，并增加 操作员。 9.4T MRI扫描仪最近已升级，并且有计划扩展Micropet/ SPECT/CT成像服务和功能。展望未来，超声成像子核将是 建立并可供具有用于独立和辅助使用的费用服务结构的用户使用（否 要求CCSG资金）。内部审查并遵循用户的请求后，图像分析组件 以前包含在UCCCC图像计算，分析和存储库核心（ICAR）中 进入Isairr。更具体地说，它已被整合到MicroPET/SPECT/CT子核心中。这样的 整合通过在 分子成像。