An MR-Compatible Small Animal SPECT Based on Artifical Compound Eye Cameras

基于人工复眼相机的 MR 兼容小动物 SPECT

基本信息

批准号：
9353404
负责人：
Chin-Tu Chen
金额：
$ 58.55万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-15 至 2020-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9353404
关键词：
3-Dimensional Animals Autoradiography Biological Models Brain Brain Neoplasms Caliber Chairperson Chicago Collimator Computer software Detection Development Dimensions Early Diagnosis Engineering Evaluation Excision Exploratory/Developmental Grant for Diagnostic Cancer Imaging Feasibility Studies Fluorescence Microscopy Future Gamma Cameras Generations Goals Grant Human Image Imaging Techniques Injectable Journals Legal patent Letters Magnetic Resonance Imaging Malignant neoplasm of brain Manuscripts Modeling Modernization Monitor Monte Carlo Method Movement Mus Operating System Operative Surgical Procedures Paper Performance Physiologic pulse RF coil Reporting Research Research Design Research Project Grants Resolution Semiconductors Series Slice System Techniques Technology Therapeutic United States National Institutes of Health Wages Work base clinical practice compound eye design detector efficacy study heart imaging image reconstruction imaging approach imaging platform imaging study imaging system improved in vivo in vivo imaging instrumentation mouse model nerve stem cell neurosurgery novel pre-clinical pre-clinical research response scale up single photon emission computed tomography symposium targeted treatment tumor progression

项目摘要

This proposed project is for developing the second-generation MR-compatible SPECT system (MRC-SPECT- II). The proposed MRC-SPECT-II system, based on a novel inverted compound-eye (ICE) gamma camera design would offer the potential of dramatically improving SPECT imaging instrumentation from several aspects. First, this approach helps to tackle one of the most limiting aspects of SPECT instrumentation, by offering a dramatically improved sensitivity without sacrificing its resolution capability. The proposed MRC- SPECT-II system could offer an unprecedented sensitivity of 1.5% with a reconstructed imaging resolution of 0.5 mm across and 1.5 cm diameter field-of-view (FOV), and 9% at 1.2 mm spatial resolution (as compared to the typical levels of 0.1% - 0.01% found in modern pre-clinical SPECT instrumentations). This greatly increase in detection sensitivity could potentially provide a radical change in how we might employ SPECT imagining in pre-clinical research by offering a dramatically lowered detection limit and allowing for new imaging procedures that would not be feasible with the current generation of SPECT instrumentations. Second, the ICE-camera design allows the MRC-SPECT-II system to have a significantly reduced physical dimension, while compared to any existing SPECT systems with similar FOV. This would allow the MRC-SPECT-II system (and future MRC-SPECT systems based on similar ICE camera design) to be integrated in most of existing MR scanners. Third, the ICE camera design could also offer dramatically improved sensitivities for scaled-up SPECT scanners for large animals and for human (e.g. brain and heart) imaging applications. Finally, the proposed MRC-SPECT-II system allows for simultaneous SPECT and high-field (9.4T) MR imaging studies. Within this particular project, the MRC-SPECT-II system will be developed and refined for in vivo study of the efficacy and fate of therapeutically engineered neural stem cells in malignant brain tumors, which could help to bring this promising therapeutic approach into clinical practice.

该拟议项目旨在开发第二代 MR 兼容 SPECT 系统（MRC-SPECT- 二）。所提出的 MRC-SPECT-II 系统基于新型倒置复眼 (ICE) 伽马相机设计将提供显着改进 SPECT 成像仪器的潜力方面。首先，这种方法有助于解决 SPECT 仪器最限制的方面之一：在不牺牲分辨率能力的情况下提供显着提高的灵敏度。拟议的 MRC- SPECT-II 系统可提供前所未有的 1.5% 灵敏度和 1.5% 的重建成像分辨率宽度为 0.5 毫米，视野 (FOV) 直径为 1.5 厘米，空间分辨率为 1.2 毫米时为 9%（与现代临床前 SPECT 仪器中的典型水平为 0.1% - 0.01%）。这大大增加了检测灵敏度的提高可能会彻底改变我们如何使用 SPECT 成像通过提供显着降低的检测限并允许新的成像程序来进行临床前研究这对于当前一代 SPECT 仪器来说是不可行的。二、ICE相机设计使得 MRC-SPECT-II 系统的物理尺寸显着减小，而与任何现有的具有类似 FOV 的 SPECT 系统。这将使 MRC-SPECT-II 系统（以及未来的基于类似 ICE 相机设计的 MRC-SPECT 系统）将集成到大多数现有 MR 扫描仪中。第三，ICE 相机设计还可以显着提高放大 SPECT 的灵敏度用于大型动物和人体（例如大脑和心脏）成像应用的扫描仪。最后，提出的 MRC-SPECT-II 系统允许同时进行 SPECT 和高场 (9.4T) MR 成像研究。在此范围内特定项目中，MRC-SPECT-II 系统将被开发和完善，用于体内研究功效和治疗工程神经干细胞在恶性脑肿瘤中的命运，这可能有助于实现这一目标有前景的治疗方法进入临床实践。