An MR-Compatible Small Animal SPECT Based on Artifical Compound Eye Cameras

基于人工复眼相机的 MR 兼容小动物 SPECT

基本信息

批准号：
9752622
负责人：
Chin-Tu Chen
金额：
$ 56.65万
依托单位：
UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-09-15 至 2022-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9752622
关键词：
3-Dimensional Animals Autoradiography Biological Models Brain Brain Neoplasms Caliber Chairperson Chicago Collimator Computer software Detection Development Dimensions Early Diagnosis Engineering Evaluation Excision Exploratory/Developmental Grant for Diagnostic Cancer Imaging Feasibility Studies Fluorescence Microscopy Future Gamma Cameras Generations Goals Grant Human Image Imaging Techniques Journals Legal patent Letters Magnetic Resonance Imaging Malignant neoplasm of brain Manuscripts Modeling Modernization Monitor Monte Carlo Method Movement Mus Operating System Operative Surgical Procedures Paper Performance Physiologic pulse RF coil Reporting Research Research Design Research Project Grants Resolution Semiconductors Series Slice System Techniques Technology Therapeutic United States National Institutes of Health Wages Work base clinical practice compound eye design detector efficacy study heart imaging image reconstruction imaging approach imaging platform imaging study imaging system improved in vivo in vivo imaging instrumentation mouse model nerve stem cell neurosurgery novel off-patent pre-clinical pre-clinical research response scale up single photon emission computed tomography symposium targeted treatment tumor progression

3-Dimensional Animals Autoradiography Biological Models Brain Brain Neoplasms Caliber Chairperson Chicago Collimator Computer software Detection Development Dimensions Early Diagnosis Engineering Evaluation Excision Exploratory/Developmental Grant for Diagnostic Cancer Imaging Feasibility Studies Fluorescence Microscopy Future Gamma Cameras Generations Goals Grant Human Image Imaging Techniques Journals Legal patent Letters Magnetic Resonance Imaging Malignant neoplasm of brain Manuscripts Modeling Modernization Monitor Monte Carlo Method Movement Mus Operating System Operative Surgical Procedures Paper Performance Physiologic pulse RF coil Reporting Research Research Design Research Project Grants Resolution Semiconductors Series Slice System Techniques Technology Therapeutic United States National Institutes of Health Wages Work base clinical practice compound eye design detector efficacy study heart imaging image reconstruction imaging approach imaging platform imaging study imaging system improved in vivo in vivo imaging instrumentation mouse model nerve stem cell neurosurgery novel off-patent pre-clinical pre-clinical research response scale up single photon emission computed tomography symposium targeted treatment tumor progression

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项目摘要

This proposed project is for developing the second-generation MR-compatible SPECT system (MRC-SPECT- II). The proposed MRC-SPECT-II system, based on a novel inverted compound-eye (ICE) gamma camera design would offer the potential of dramatically improving SPECT imaging instrumentation from several aspects. First, this approach helps to tackle one of the most limiting aspects of SPECT instrumentation, by offering a dramatically improved sensitivity without sacrificing its resolution capability. The proposed MRC- SPECT-II system could offer an unprecedented sensitivity of 1.5% with a reconstructed imaging resolution of 0.5 mm across and 1.5 cm diameter field-of-view (FOV), and 9% at 1.2 mm spatial resolution (as compared to the typical levels of 0.1% - 0.01% found in modern pre-clinical SPECT instrumentations). This greatly increase in detection sensitivity could potentially provide a radical change in how we might employ SPECT imagining in pre-clinical research by offering a dramatically lowered detection limit and allowing for new imaging procedures that would not be feasible with the current generation of SPECT instrumentations. Second, the ICE-camera design allows the MRC-SPECT-II system to have a significantly reduced physical dimension, while compared to any existing SPECT systems with similar FOV. This would allow the MRC-SPECT-II system (and future MRC-SPECT systems based on similar ICE camera design) to be integrated in most of existing MR scanners. Third, the ICE camera design could also offer dramatically improved sensitivities for scaled-up SPECT scanners for large animals and for human (e.g. brain and heart) imaging applications. Finally, the proposed MRC-SPECT-II system allows for simultaneous SPECT and high-field (9.4T) MR imaging studies. Within this particular project, the MRC-SPECT-II system will be developed and refined for in vivo study of the efficacy and fate of therapeutically engineered neural stem cells in malignant brain tumors, which could help to bring this promising therapeutic approach into clinical practice.

该提出的项目用于开发第二代MR兼容SPECT系统（MRC-Spect-- ii）。拟议的MRC-spect-II系统，基于一种新颖的倒置化合物（ICE）伽马相机设计将提供从几种巨大改进Spect Imaging仪器的潜力方面。首先，这种方法有助于解决Spect Instrumentation的最限制方面之一提供明显提高的灵敏度，而无需牺牲其分辨率。提议的MRC- Spect-II系统可以通过重建成像分辨率的前所未有的灵敏度为1.5％跨直径为0.5毫米，视野（FOV）为1.5 cm，在1.2 mm空间分辨率下（与在现代临床前光谱仪器中发现的0.1％-0.01％的典型水平）。这大大增加了在检测中，灵敏度可能会在我们可能想象中采用Spect的方式有根本性的改变临床前研究通过提供大幅降低的检测极限并允许新成像程序对于当前的Spect仪器，这是不可行的。第二，冰摄像机设计允许MRC-Spect-II系统具有显着降低的物理维度，同时比较对于具有类似FOV的任何现有SPECT系统。这将允许MRC-Spect-II系统（以及未来基于类似冰心摄像机设计的MRC-spect系统将集成在大多数现有MR扫描仪中。第三，冰相机设计还可以极大地提高敏感性，以缩放SPECT 大型动物以及人类（例如大脑和心脏）成像应用的扫描仪。最后，提议 MRC-Spect-II系统允许同时进行SPECT和高场（9.4T）MR成像研究。在此特定项目，将开发和完善MRC-spect-II系统，以在体内研究功效和在恶性脑肿瘤中治疗设计的神经干细胞的命运，这可能有助于带来有希望的临床实践治疗方法。