Development of new central neuropathic pain model

新中枢神经病理性疼痛模型的开发

• 批准号: 23659747
• 负责人: YAMAMOTO Tatsuo
• 金额: $ 2.33万
• 依托单位: Kumamoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23659747/
• 关键词: 疼痛管理学; 神経障害性疼痛; 神経障害性疼痛モデル; 中枢神経; 視床; 視床痛

Neuropathic pain is defined as pain arising as a direct consequence of a lesion or diseaseaffecting the somatosensory system. There are two types of neuropathic pain, such asperipheral neuropathic pain and central neuropathic pain. Neuropathic pain is known tobe refractory to drug therapy . Especially , central neuropathic pain is an intractable pain. We have no clinically relevant animal central neuropathic pain model and this is why newefficacious therapy was not developed. In this project, I intended to develop new centralneuropathic pain model. I injected blood to various brain regions, such as thalamus. Unfortunately , I could not find any sings of central pain which mimic clinical centralneuropathic pain

神经性疼痛被定义为疼痛，是病变或疾病的直接结果。神经性疼痛有两种类型的疼痛，例如天质神经性疼痛和中枢神经性疼痛。神经性疼痛已知对药物治疗难治性。特别是，中枢神经性疼痛是一种棘手的疼痛。我们没有临床相关的动物中央神经性疼痛模型，这就是为什么未开发新效能疗法的原因。在这个项目中，我打算开发新的中枢性神经性疼痛模型。我向丘脑等各个大脑区域注射血液。不幸的是，我找不到任何模仿临床中心疼痛的中心疼痛的唱片

项目成果

The potency oftramadol and acetaminophen onneuropathic pain is different fromthat on inflammatory pain

曲马多和对乙酰氨基酚对神经性疼痛的功效与对炎性疼痛的功效不同

• 发表时间: 2012
• 作者: Shinozaki T;Yamada T;Ishimura T,Yamamoto T
• 通讯作者: Ishimura T,Yamamoto T

PAG and RVM administration ofN-Acetyl-aspartyl- glutamate (NAAG)peptidase inhibitors is analgesic ininflammatory pain via mGluR3activation and inhibition ofglutamate release

PAG 和 RVM 施用 N-乙酰基-天冬氨酰-谷氨酸 (NAAG) 肽酶抑制剂可通过 mGluR3 激活和谷氨酸释放抑制来镇痛炎性疼痛

• 发表时间: 2011
• 作者: Yamada T;Yamamoto T;Zuo D;Neale JH
• 通讯作者: Neale JH

N-acetyl-aspartylglutamate (NAAG) peptidase inhibitoris analgesic in rat formalin test viamGluR3 activation

N-乙酰-天冬氨酰谷氨酸 (NAAG) 肽酶抑制剂通过 mGluR3 激活在大鼠福尔马林试验中镇痛

• 发表时间: 2012
• 作者: Yamada T;Shinozaki T;Ishimura T,Yamamoto T
• 通讯作者: Ishimura T,Yamamoto T

BiP, an endoplastic reticulumchaperone, modulate the develop- mentof morphine withdrawal syndrome

BiP，一种内质网状伴侣，调节吗啡戒断综合征的发展

• 发表时间: 2011
• 作者: Shinozaki T;Aoe T;Yamamoto T
• 通讯作者: Yamamoto T