Investigation of the brain and cell injury responsible for depression with immune-challenged animal model

用免疫缺陷动物模型研究导致抑郁症的大脑和细胞损伤

• 批准号: 22390226
• 负责人: KANBA Shigenobu
• 金额: $ 11.65万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22390226/
• 关键词: うつ病; サイトカイン; 精神疾患; 神経科学; 脳; 動物モデル

By systemic injection of bacterial endotoxin into mice, we generated an animal model of depression which showed depressive behavior and microglial activation in the regions around the periventricular organs. In another experiment on forced swim test, some

通过全身注射细菌内毒素到小鼠中，我们产生了一种抑郁症模型，该模型在周围的脑室器官周围的区域显示出抑郁行为和小胶质细胞激活。在另一个强制游泳测试的实验中，有些

项目成果

Controversies and New Treatment of Diabetes

糖尿病的争议和新治疗方法

• 发表时间: 2010
• 作者: Kanba;S
• 通讯作者: S

Reduced high and low frequency gamma synchronization in patients with chronic schizophrenia

• DOI: 10.1016/j.schres.2011.07.020
• 发表时间: 2011-12
• 期刊: Schizophrenia Research
• 影响因子: 4.5
• 作者: R. Tsuchimoto;S. Kanba;S. Hirano;N. Oribe;T. Ueno;Y. Hirano;I. Nakamura;Y. Oda;T. Miura;T. Onitsuka

cAMP response element-binding protein (CREB) is required for epidermal growth factor (EGF)-induced cell proliferation and serum response element activation in neural stem cells isolated from the forebrain subventricular zone of adult mice

• DOI: 10.1507/endocrj.k11e-104
• 发表时间: 2011-09-01
• 期刊: ENDOCRINE JOURNAL
• 影响因子: 2
• 作者: Iguchi, Hironobu;Mitsui, Tetsuo;Arita, Jun
• 通讯作者: Arita, Jun

Systemic lipopolysaccharaide induces prolonged microglial activation in specific brain regions in mice.

全身性脂多糖可诱导小鼠特定大脑区域的小胶质细胞长时间激活。

• 发表时间: 2011
• 作者: Rebecca Wong;Ren Iwata;Hidekazu Saiki;Shozo Furumoto;Yoichi Ishikawa;Eiichi Ozeki;Ohashi A et al.
• 通讯作者: Ohashi A et al.

Minocycline modulates human social decision-making: possible impact of microglia on personality-oriented social behaviors.

• DOI: 10.1371/journal.pone.0040461
• 发表时间: 2012
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kato TA;Watabe M;Tsuboi S;Ishikawa K;Hashiya K;Monji A;Utsumi H;Kanba S
• 通讯作者: Kanba S