A ROLE OF INTERLEUKIN-1 IN PATHOGENESIS OF MANIC-DEPRESSIVE-ILLNESS

白介素 1 在躁狂抑郁症发病机制中的作用

• 批准号: 08457252
• 负责人: KANBA Shigenobu
• 金额: $ 1.79万
• 依托单位: YAMANASHI MEDICAL UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08457252/
• 关键词: manic depressive illness; stress; cytokine; vasopressin; TNF; interleukin; inteferon; インターロイキン-1; インターロイキン-1受容体アンタゴニスト; 視床下部; HPA系

Interleukin-1 (IL-1) and IL-1, receptor antagonist mRNA levels peaked at approximately 0.5 and 2-4 hr, respectively. The maximum mRNA levels of IL-1b were 15-fold higher than pre-immobilization levels, whereas those of IL-1 receptor antagonists were 250-fold higher in the hypothalamus. After the biosynthesis of IL-1b has peaked, IL-1 receptor antagonist may contribute to attenuation of the IL-1 activity which has been enhanced by immobilization.Chronic treatments of psychotropics for 28 days raised the levels of both mRNAs. The increase in IL-1 receptor antagonist mRNA was 6-112 times larger than that of IL-1b mRNA in most brain regions examined. These results suggest that chronic treatment with psychotropics causes greater amplifying effects on IL-1 receptor antagonist than IL-1b mRNA in the brain.

白介素-1（IL-1）和IL-1，受体拮抗剂mRNA水平分别在约0.5和2-4小时峰值。 IL-1B的最大mRNA水平比进前液化水平高15倍，而在下丘脑中，IL-1受体拮抗剂的MRNA水平高250倍。在IL-1B的生物合成峰值之后，IL-1受体拮抗剂可能有助于衰减IL-1活性，而IL-1活性已通过固定化增强。精神疗法的chronic治疗28天增加了两个mRNA的水平。在所检查的大多数大脑区域中，IL-1受体拮抗剂mRNA的增加是IL-1B mRNA的6-112倍。这些结果表明，与大脑中的IL-1B mRNA相比，用精神药物的慢性治疗对IL-1受体拮抗剂会产生更大的扩增作用。

项目成果

Suzuki,E: "Immobilization stress increases mRNA levels of interleukin-1 receptor omtagonist in various rat brain regions" Cell.Molec.Neurobiol.17・5. 557-562 (1997)

Suzuki, E：“固定应激会增加大鼠不同脑区中白细胞介素 1 受体拮抗剂的 mRNA 水平”Cell.Molec.Neurobiol.17・5 (1997)。

Szuki, E., Shintani, F., Kanba, S., Asai, M., and Nakaki, T.: "Immobilization stress increases mRNA levels of interleukin-1 receptor antagonist in various rat brain regions." Cell Mol Neurobiol. 17. 557-562 (1997)

Szuki, E.、Shintani, F.、Kanba, S.、Asai, M. 和 Nakaki, T.：“固定应激会增加大鼠不同脑区中白细胞介素 1 受体拮抗剂的 mRNA 水平。”

Suzuki, E: "Immobilization stress increases mRNA levels of interleukin-1 receptor omtagonist in various rat brain regions" Cell.Molec.Neurobiol.17・5. 557-562 (1997)

Suzuki, E：“固定应激会增加大鼠不同脑区中白细胞介素 1 受体拮抗剂的 mRNA 水平”Cell.Molec.Neurobiol.17・5 (1997)。

Suzuki,E et al.: "Immobilization stress incleases mRNA levels of interleukin-1 receptor antagonist in various rat brain regions" Cell.Mol.Neurobiol.(in press).

Suzuki,E 等人：“固定应激会增加大鼠不同脑区中白细胞介素 1 受体拮抗剂的 mRNA 水平”Cell.Mol.Neurobiol.（出版中）。