Is cytokine from adipose tissue associated with metabolic syndrome?

脂肪组织中的细胞因子与代谢综合征有关吗？

• 批准号: 18590621
• 负责人: ADACHI Hisashi
• 金额: $ 2.57万
• 依托单位: Kurume University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2006
• 资助国家: 日本
• 起止时间: 2006 至 2007
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590621/
• 关键词: Health care; Disease prevention; Cytokine; Metabolic syndrome; Epidemiology

The relationships between plasma concentrations of monocyte chemoattractant protein-1 (MCP-1), hepatocyte growth factor (HGF), plasminogen activator ihhibitor-1 (PAI-1) and TNF-α and the metabolic syndrome were examined in a Japanese general population. In 1999, we conducted a health examination in 1,492 subjects, aged 40 years or older in a farming community, Tanushimaru, Fukuoka, Japan. We measured HGF and PAI-1 in addition to conventional risk factors. We also performed a health examination in 842 subjects in a fishing community, Uku Island, Nagasaki, Japan in 2004-2007. We measured adipocytekine such as MCP-1, PAI-1, and TNF-α. With multiple linear regression analysis after adjustments for age, sex, and confounders, MCP-1 and PAI-1 were significantly related to insulin resistance, and also HGF and TNF-α were associated with the component of the metabolic syndrome. HGF and TNF-α levels were higher (p<0.05) in proportion to the accumulation of the number of the metabolic syndrome. In conclusion, our results indicate that serum HGF and TNF-α are strongly associated with the metabolic syndrome. It is very interesting that comparing the strength of associations between adipocytekine and the metabolic syndrome in different districts (farming and fishing areas). A longitudinal epidemiological survey may be needed to be clarified the area difference between them in the near future.

血浆浓缩蛋白1（MCP-1），肝细胞生长因子（HGF）或IHHIBITOR-1（PAI-1）和TNF-α与代谢综合征之间的关系在1999年进行了研究。在1,492个受试者中，日本Tanushimaru和Pai-1年龄40岁以上。 2004-2007，我们测量了具有多个的MCP-1的脂肪细胞。胰岛素抵抗以及HGF-TNF-αF和TNF-α水平的水平较高（P <0.05），与代谢综合征数量的积累成比例。与Tabolic综合征相关。

项目成果

Ciroulating advanced glycation end produots(AGEs) and soluble form of receptor for AGEs(sRAGE) are independent detemlinants of serum monocyte chemoattraotant protein-1 (MCP-1) levels in patients with type 2 diabetes

循环晚期糖基化终末产物 (AGE) 和可溶性 AGE 受体 (sRAGE) 是 2 型糖尿病患者血清单核细胞趋化蛋白 1 (MCP-1) 水平的独立决定因素

• 发表时间: 2008
• 期刊: Diabetes Metab Res Rev 24(2)
• 作者: Nakamura K;Yamagishi S;Adachi H;et. al.
• 通讯作者: et. al.

Strong association between serum hepatocyte growth factor(HGF) and metabolic syndrome.

血清肝细胞生长因子（HGF）与代谢综合征之间有很强的相关性。

• 发表时间: 2005
• 期刊: J Clin Endocrinol Metab 90
• 作者: Hiratsuka A;Adachi H.;et. al.
• 通讯作者: et. al.

Habitual coffee but not green tea consumption is inversely associated with metabolic syndrome -An epidemiological study in a Japanese population-

习惯性喝咖啡而不是绿茶与代谢综合征呈负相关——一项针对日本人群的流行病学研究——

• 发表时间: 2007
• 期刊: Diabetes Res Clin Pract 76
• 作者: Hino H;Adachi H;Enomoto M;et. al.
• 通讯作者: et. al.

Serum level of advanced glycation end-products(AGEs) is an independent determinant of plasminogen activator ihhibitor- 1 (PAl- 1) in nondiabetic general population

在非糖尿病普通人群中，晚期糖基化终末产物 (AGE) 的血清水平是纤溶酶原激活剂 ihhibitor-1 (PAl-1) 的独立决定因素

• 发表时间: 2007
• 期刊: Horm Metab Res 39
• 作者: Yamagishi S;Adachi H;et. al.
• 通讯作者: et. al.

Circulating advanced glycation end products (AGEs) and soluble form of receptor for AGEs (sRAGE) are independent determinants of serum monocyte chemoattractant protein-1 (MCP-1) levels in patients with type 2 diabetes

• DOI: 10.1002/dmrr.766
• 发表时间: 2008-02-01
• 期刊: DIABETES-METABOLISM RESEARCH AND REVIEWS
• 影响因子: 8
• 作者: Nakamura, Kazuo;Yamagishi, Sho-ichi;Imaizumi, Tsutomu
• 通讯作者: Imaizumi, Tsutomu