An association between atherosclerosis in the carotid ultrasonography and a novel risk factor of cardio-vascular diseases

颈动脉超声检查中动脉粥样硬化与心血管疾病新危险因素之间的关联

基本信息

批准号：
16590525
负责人：
ADACHI Hisashi
金额：
$ 2.3万
依托单位：
Kurume University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

The relationships between plasma concentrations of homocysteine (Hcy), hepatocyte growth factor (HGF) or asymmetric dimethylarginine (ADMA) and hypertension as well as carotid atherosclerosis were examined in a Japanese general population. In 1999, we conducted a health examination in 1,920 subjects, aged 40 years or older in a farming community, Tanushimaru, Japan. We measured conventional risk factors such as body mass index(BMI), blood pressure (BP), smoking status, total cholesterol, HDL-cholesterol, and glycosylated hemoglobin A_<1c>. Subjects underwent B-mode carotid ultrasonography to determine the carotid intimal-medial thickness (IMT). Of these subjects, Hcy, HGF, and ADMA levels were measured in 1,111 (452 men and 659 women), 1,474 (597 men and 877 women) and 712 (305 men and 407 women) cases, respectively. With multiple linear regression analysis after adjustments for age, sex, and creatinine levels, BMI (p<0.01), systolic and diastolic blood pressure (p<0.001), HDL-cholesterol(p<0.001, inversely), glycosylated hemoglobin A_<1c> (p<0.001), and Hcy levels (p<0.05) were significantly related to IMT. Although HGF was related to the severity of hypertension, the levels were not related to IMT. On the contrary, elevated levels of ADMA were a strong and independent determinant of IMT of the carotid artery. In addition to conventional risk factors such as hypertension and impaired glucose metabolism, Hcy is a novel risk factor for carotid atherosclerosis. And, we suggested that plasma ADMA was the strongest predictor for the progression of carotid IMT in a prospective study for 6 years with carotid ultrasonography.

在日本普通人群中检查了血浆同型半胱氨酸（HCY），肝细胞生长因子（HGF）或非对称二甲基精氨酸（ADMA）以及颈动脉粥样硬化的关系。 1999年，我们在日本塔努希马鲁（Tanushimaru）的农业社区中对1,920名受试者进行了健康检查，年龄在40岁或40岁以上。我们测量了常规危险因素，例如体重指数（BMI），血压（BP），吸烟状况，总胆固醇，HDL-胆固醇和糖基化血红蛋白A_ <1C>。受试者进行了B模式颈动脉超声检查，以确定颈动脉内膜厚度（IMT）。在1,111名（452名男性和659名女性），1,474名（597名男性和877名女性）和712例（305名男性和407名女性）案件中，测量了这些受试者，HCY，HGF和ADMA水平。通过调整年龄，性别和肌酐水平后进行多个线性回归分析，BMI（p <0.01），收缩压和舒张压（p <0.001），HDL-胆固醇（p <0.001），糖基化血红蛋白A_ <1C <1C <1C <1C >（P <0.001），HCY水平（P <0.05）与IMT显着相关。尽管HGF与高血压的严重程度有关，但水平与IMT无关。相反，ADMA水平升高是颈动脉IMT的强大而独立的决定因素。除了传统的危险因素（例如高血压和葡萄糖代谢受损，HCY）是颈动脉粥样硬化的新风险因素。而且，我们建议血浆ADMA是颈动脉超声检查的前瞻性研究中颈动脉IMT进展的最强预测指标。