Association of plasma remnant-like particle cholesterol with insulin resistance in a Japanese general population

日本普通人群血浆残留样颗粒胆固醇与胰岛素抵抗的关系

• 批准号: 12670374
• 负责人: ADACHI Hisashi
• 金额: $ 0.32万
• 依托单位: The Third Department of Intornal Medicine, Kurume University school of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2000
• 资助国家: 日本
• 起止时间: 2000 至 2001
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-12670374/
• 关键词: Romnant; Risk tactor; Athzrogenesis; Health axamination; Insulin resistance; レムナント様リポ蛋白コレステロール; 動脈硬化; 疫学的研究

Remnant lipoprotein contains chylomicron and very low density lipoprotein (VLDL). Insulin resistance is characterized by dyslipidemia. Thus, it is suggested that increases of remnant lipoprotein cholesterol are associated with insulin resistance syndrome. Therefore, we investigated an association of renmant-like lipoprotein particle (RLP) cholesterol with insulin resistance in a Japanese farming community where the dietary habit is different and the incidence of coronary artery disease is lower compared to those of western countries. A total of 1,492 subjects received a health examination in 1999.Of these, data for fasting RLP-c levels of 1,465 subjects (591 males and 874 females ; mean age, 62.7 years) were obtained. Subjects under medication with lipid lowering drugs, oral hypoglycemic agent or insulin injection were eliminated from this analysis. A complete data set was available in 1,305 subjects. We also measured body mass index, waist-hip ratio, systolic and diastolic blood press … More ure, HDL-cholesterol, triglycerides, glucose, insulin, glycosylated hemoglobin A_<1c> (HbAic), and uric acid. We used HOMA index, which was calculated from fasting glucose and insulin values, as an index for insulin resistance. Waist-hip ratio and HOMA index were divided into quintiles of the increasing values. HbA_<1c> levels were divided into four groups (less than 4.9 %, 5.0-5.4%, 5.5-5.9 %, and more than 6.0 %). The mean RLP-c values were 3.52 mg/dl in males and 3.46 mg/dI in females. The parameters except for blood pressure were significantly (p<O.O01) associated with RLP-c by the use of analysis of covariance, adjusted for age, sex, and antihypertensive medication as covariates. RLP-c levels by the groups of HbAic, waist-hip ratio, and HOMA index showed clear dose response relationships (p<0.001) after adjustments for age, sex, and antihypertensive medication. This is the first demonstration that RLP-c was significantly related to insulin resistance syndrome in an epidemiological study. Less

残留脂蛋白含有乳糜微粒和非常低的密度脂蛋白（VLDL）。胰岛素抵抗的特征是血脂异常。这就是建议，残留脂蛋白胆固醇的增加与胰岛素抵抗综合征有关。因此，我们调查了日本农业习惯不同的日本农业习惯中的类似人类样脂蛋白颗粒（RLP）胆固醇与胰岛素抵抗的关联，在饮食习惯不同，与西方国家相比，冠状动脉疾病的发生率较低。 1999年，共有1,492名受试者接受了健康检查。这些数据是1,465名受试者（591名男性和874名女性；平均年龄，62.7岁）的空腹RLP-C水平的数据。从该分析中消除了接受脂质降低药物，口服降血糖剂或胰岛素注射的受试者。在1,305名受试者中提供了完整的数据集。我们还测量了体重指数，腰围比，收缩期和舒张血压……更多，HDL-胆固醇，甘油三酸酯，葡萄糖，胰岛素，糖基化血红蛋白A_ <1C>（HBAIC）和尿酸。我们使用了HOMA指数，该指数是根据禁食葡萄糖和胰岛素值计算的，作为胰岛素抵抗的指数。腰椎比和HOMA指数分为增加值的五分之一。 HBA_ <1c>水平分为四组（小于4.9％，5.0-5.4％，5.5-5.9％，超过6.0％）。男性的平均RLP-C值为3.52 mg/dL，女性为3.46 mg/di。通过使用协方差分析，针对年龄，性别和降压药作为协变量，通过使用协方差分析，与RLP-C相关的血压除外的参数显着（P <o.O01）。在调整年龄，性别和降压药后，HBAIC，腰围比和HOMA指数组的RLP-C水平显示明确的剂量反应关系（P <0.001）。这是第一次证明RLP-C与胰岛素抵抗综合征显着相关，在流行病学研究中。较少的

项目成果

足達 寿 他: "地域集団におけるレムナント様リポ蛋白コレステロールとインスリン抵抗性の関連"Japanese Circulation Journal. Vol.64 Supple.1. 309 (2000)

Hisashi Adachi 等人：“地区人群中残留样脂蛋白胆固醇与胰岛素抵抗之间的关系”，日本循环杂志第 64 卷增刊 309（2000 年）。

Hisashi Adachi et al.: "Association of plasma Remnant-like Particle cholesterol with insulin resistance in a Japanese general population"Circulation. Vol.102 No.18. II868 (2000)

Hisashi Adachi 等人：“日本普通人群中血浆残留样颗粒胆固醇与胰岛素抵抗的关联”循环。

Hisashi Adachi et al: "Association of plasma Remnant-like particle cholesterol with insul in a Japanese general population"Circulation(abstruct). Vol.102.No.18. II868 (2000)

Hisashi Adachi 等人：“日本普通人群中血浆残留样颗粒胆固醇与胰岛素的关联”循环（摘要）。

Makoto Tsuruta, Hisashi Adachi et al: "Association of plasma Remnant-like particle cholesterol with insul in a Japanese general population"Japanese cieculation Journal. Vol.64, Supple 1. 309 (2000)

Makoto Tsuruta、Hisashi Adachi 等人：“日本一般人群中血浆残留样颗粒胆固醇与胰岛素的关联”日本循环杂志。

Hisashi Adachi et al.: "Association of plasma Remnant-like particle cholesterol with insulin resistonce in a Jajpanese general population"Circulation. Vol.102 No.18. II868 (2000)

Hisashi Adachi 等人：“日本一般人群中血浆残留样颗粒胆固醇与胰岛素抵抗的关联”循环。