Serum hepatocyte growth factor concentration is related to hypertension-An epidemiological study-

血清肝细胞生长因子浓度与高血压相关-流行病学研究-

• 批准号: 14570368
• 负责人: ADACHI Hisashi
• 金额: $ 2.62万
• 依托单位: KURUME UNIVERSITY
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2002
• 资助国家: 日本
• 起止时间: 2002 至 2003
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-14570368/
• 关键词: Adipocyte; Cytokine; Epidemiology; Insulin resistance; Atherosclerosis; 肝細胞増殖因子; 内皮機能; 内皮機能障害; 住民検診; von willebrand factor; フィブリノーゲン; 高血圧

Hepatocyte growth factor (HGF) is one of adipo-cytokines. We evaluated whether serum levels of HGF are related to the components of the metabolic, syndrome (MS). A total of 1,474 subjects of a general population free of liver, kidney, and lung diseases received a health examination. We measured blood pressure (BP), waist circumference, body mass index (BMI), fasting plasma glucose (FPG), lipid profiles, serum insulin, and HGF concentrations. Uni-and multivariate analyses for determinant of HGF were performed. In a univariate analysis, all of the components (waist circumference, triglycerides, I-IDL-cholesterol, BP, and FPG) of the MS were significantly related to HGF levels. By the use of multiple stepwise regression analysis, HGF levels were significantly related to the components of the MS such as waist circumference (p<0.001), HDL-cholesterol (p<0.001,inversely), and systolic BP p<0.05). When HGF levels adjusted for age, sex and BMI were divided into quartiles, they linearly increased as waist circumference increased (p<0.001), and decreased as HDL-cholesterol increased (p<0.001). A linear significant trend. (p<0.001) was shown between HGF levels and aggregation of the components of the MS. Our results indicate that serum HGF levels are strongly associated with the components of the MS.

肝细胞生长因子（HGF）是脂肪促成因子之一。我们评估了HGF的血清水平是否与代谢，综合征（MS）的成分有关。共有1,474名普通人群没有肝脏，肾脏和肺部疾病接受健康检查。我们测量了血压（BP），腰围，体重指数（BMI），空腹血糖（FPG），脂质谱，血清胰岛素和HGF浓度。进行了HGF决定概念的UNI-和多元分析。在单变量分析中，MS的所有成分（腰围，甘油三酸酯，I-IDL-胆固醇，BP和FPG）与HGF水平显着相关。通过使用多个逐步回归分析，HGF水平与MS的成分显着相关，例如腰围（p <0.001），HDL-胆固醇（P <0.001，成反比）和收缩压BP P <0.05）。当针对年龄调整的HGF水平时，性别和BMI被分为四分位数，随着腰围的增加，它们线性增加（p <0.001），并随着HDL-胆固醇的增加而降低（p <0.001）。线性重大趋势。 （p <0.001）在HGF水平和MS组件的聚集之间显示。我们的结果表明，血清HGF水平与MS的成分密切相关。

项目成果

Hiratsuka A, Adachi H. et al.: "Obesity is related to increased levels of serum hepatocyte growth factor (HGF)"Circulation Journal. SuppleI 68. 14 (2004)

Hiratsuka A、Adachi H. 等人：“肥胖与血清肝细胞生长因子 (HGF) 水平升高有关”循环杂志。

Hiratsuka A, Adachi H et al.: "Obesity is related to increased levels of serum hepatocyte growth factor (HGF)"Circulation Journal Supple I. 68. 114 (2004)

Hiratsuka A、Adachi H 等人：“肥胖与血清肝细胞生长因子 (HGF) 水平升高有关”Circulation Journal Supple I. 68. 114 (2004)

Akiko Hiratsuka, Hisashi Adachi: "Serum hepatocyte growth factor, concentration is related to hypertension-An Epidemiological Study-"Cireulation. 106 II-733. 733 (2002)

Akiko Hiratsuka、Hisashi Adachi：“血清肝细胞生长因子、浓度与高血压相关-一项流行病学研究-”循环。

Akiko Hiratsuka, Hisashi Adachi: "Serum hepatocyte growth factor, concentration is related to hypertension-An Epidemiological Study-"Journal of Hyperleusion. 22,suppl.I. S208 (2004)

Akiko Hiratsuka、Hisashi Adachi：“血清肝细胞生长因子、浓度与高血压相关-一项流行病学研究-”Journal of Hyperleusion。

Hisashi Adachi, Yuji Hirai et al.: "Novel risk factors for cardiovascular disease : an epidemiological study in Tanushimaru Japan"Backhuys Publishers. 213-218 (2001)

Hisashi Adachi、Yuji Hirai 等：“心血管疾病的新危险因素：日本田主丸的流行病学研究”Backhuys 出版社。