The effect of food factors on postprandial hyperlipidemia - the search for food factors and the clarification of those mechanisms -

食物因素对餐后高脂血症的影响——寻找食物因素并阐明其机制——

• 批准号: 15300252
• 负责人: KONDO Kazuo
• 金额: $ 10.56万
• 依托单位: Ochanomizu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2003
• 资助国家: 日本
• 起止时间: 2003 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15300252/
• 关键词: postprandial hyperlipidemia; fat load; Caco-2; lemon flavonoids; EGC; EGCg; 透過実験; エリオシトリン; 緑茶; 茶カテキン; カイロミクロン

Recently, postprandial hyperlipidemia has been recognized to be a risk factor for atherosclerosis development. Four years ago, we evaluated the effect of three kinds of mayonnaise with differing fat contents on hyperlipidemia. The results showed that the serum and chylomicron TG levels after the ingestion of TG half-energy mayonnaise were significantly lower than those for the TG mayonnaise. In addition, the chylomicron TG levels after ingestion of the DG mayonnaise were higher than those for the TG mayonnaise. Moreover, we showed that the chylomicron TG levels after the fat load decreased with the intake of green tea (p=0.0093).The next year, in addition to green tea, we evaluated the effect of lemon on postprandial hyperlipidemia. The results showed that the intake of fat with lemon significantly reduced the rise of plasma chylomicron TG levels in comparison to the intake of fat alone. Moreover, the formation of plasma TG levels was delayed. In addition, lemon flavonoids and lemon fl … More avonoids aglycon showed similar results. Therefore, these findings suggested that lemon flavonoid aglycon inhibited fat absorption.The third year, we examined the effect of EGC and EGCg on the intestinal epithelial transport of palmitic acid, using a monolayer of the human colonic cell line Caco-2 grown in transwells, which is a common model of human intestinal absorption. The results showed that the absorption of palmitic acid was significantly inhibited by EGCg but not EGC.Last year, we measured the intestinal lymph flow and lymph TG and cholesterol levels in order to confirm how lemon inhibited intestinal fat absorption. As a result, we found that the lymph flow rate decreased to a greater extent in the lemon flavonoid aglycon powder group in comparison to the control group. In addition, the absorption volume of TG significantly decreased in the lemon flavonoid aglycon powder group.In conclusion, our results have shown that flavonoids rich in green tea and lemon inhibit intestinal fat absorption, which may contribute to the prevention of postprandial hyperlipidemia. Less

最近，餐后高脂血症已被认为是动脉粥样硬化发展的危险因素。四年前，我们评估了三种不同脂肪含量的蛋黄酱对高脂血症的影响，结果显示，摄入后的血清和乳糜微粒TG水平。 TG半能蛋黄酱显着低于TG蛋黄酱，此外，摄入DG蛋黄酱后乳糜微粒TG水平较高。此外，我们还发现，随着绿茶摄入量的增加，乳糜微粒 TG 水平也随之降低 (p=0.0093)。第二年，除了绿茶之外，我们还评估了柠檬对健康的影响。结果表明，与单独摄入脂肪相比，摄入脂肪与柠檬显着降低了血浆乳糜微粒TG水平的升高。柠檬类黄酮和柠檬 fl … 更多类黄酮苷元显示出相似的结果，因此，这些发现表明柠檬类黄酮苷元抑制脂肪吸收。第三年，我们使用单层细胞检查了 EGC 和 EGCg 对棕榈酸肠上皮转运的影响。在 Transwell 中生长的人结肠细胞系 Caco-2 是人类肠道吸收的常见模型，结果表明，棕榈酸的吸收受到显着抑制。 EGCg而不是EGC。去年，我们测量了肠道淋巴流量以及淋巴TG和胆固醇水平，以确认柠檬如何抑制肠道脂肪吸收。结果，我们发现柠檬中淋巴流量下降幅度更大。与对照组相比，黄酮苷元粉组此外，柠檬黄酮苷元粉组的TG吸收量显着降低。 总之，我们的结果表明，绿茶和柠檬中富含的黄酮类物质可抑制肠道脂肪。吸收少，可能有助于预防餐后高脂血症。

项目成果

Contribution of Rho A and Rho kinase to platelet-derived growth factor-BB-induced proliferation of vascular smooth muscle cells.

• DOI: 10.5551/jat.10.117
• 发表时间: 2003-04
• 期刊: Journal of atherosclerosis and thrombosis
• 影响因子: 4.4
• 作者: M. Kamiyama;K. Utsunomiya;Kanta Taniguchi;T. Yokota;H. Kurata;N. Tajima;K. Kondo

Effect of dietary medium- and long-chain triacylglycerols (MLCT) on accumulation of body fat in healthy humans.

• 发表时间: 2003
• 期刊: Asia Pacific journal of clinical nutrition
• 影响因子: 1.3
• 作者: M. Kasai;N. Nosaka;Hideaki Maki;S. Negishi;T. Aoyama;Masahiro Nakamura;Yoshie Suzuki;H. Tsuji-

Masumi Kamiyama et al.: "Contribution of Rho A and Rho Kinase to Platelet-Derived Growth Factor-BB-Induced Proliferation of Vascular Smooth Muscle Cells."Journal of Atherosclerosis and Thrombosis. 10. 117-123 (2003)

Masumi Kamiyama 等人：“Rho A 和 Rho 激酶对血小板衍生生长因子-BB 诱导的血管平滑肌细胞增殖的贡献”。动脉粥样硬化和血栓形成杂志。

コーヒーによるLDL酸化変性の抑制に関する検討

咖啡抑制LDL氧化变性的研究

• 发表时间: 2006
• 期刊: 日本未病システム学会誌 12
• 作者: 今村知明;神奈川芳行;長谷川麻衣子 他
• 通讯作者: 長谷川麻衣子 他

The polyphenol Content and Antioxidant Activities of the Main Edible Vegetables in Northern Vietunam

越南北部主要食用蔬菜的多酚含量和抗氧化活性

• 发表时间: 2004
• 期刊: Journal of Nutritional Science And Vitaminology 50
• 作者: 馬場 敏幸;小林俊哉;南谷 崇;Fumihiko Yoshie et al.;Toshiyuki Baba Toshiya Kobayashi Jyunichi Kikuchi;Nghiem Nguyet Thu et al.
• 通讯作者: Nghiem Nguyet Thu et al.