Histologic and Hydrodynamic Evaluation of Blood Flow for Scintigraphic Detection of Malignant Tumor of the Head and Neck.

头颈部恶性肿瘤闪烁显像检测中血流的组织学和流体动力学评估。

基本信息

批准号：
07672052
负责人：
SATO Tsuyoshi
金额：
$ 1.28万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672052/
关键词：
Scintigraphy Early image Malignant tumor Blood flow Head and Neck Scintigrashy Blood flow

项目摘要

In the experiment with animals, Japan white rabbits transplanted with VX2 carcinoma in the right femoral regionwere examined histologically, angiographically and hydrodynamically. The tumor blood vessel became rich in accordance with tumor growth and the blood flow rate and the volume of the blood flow of the right femoral artery in the tumor side was approximately twice or three times as much as that in the control side (left femoral artery) by means of the ultrasonic blood flow meter (5 MHz). In the clinical examination, 117 patients with oral cancer were examined scintigraphically and histopathologically. Tumor blood flow was estimated scintigraphically immediately after administration of <@D199m@>D1Tc-HMDP.Radioactivity of venous phase (30 to 40 seconds after administration) and blood pool phase (1 to 3 minutes) were observed. Radioactive ratios of tumor to the control region in both phases were calculated ; venous ratio (VR), blood pool ratio (BPR). Early image with <@D199m@>D1Tc-HMDP (early image) was obtained 5 minutes after administration and the image with <@D167@>D1Ga-citrate (Ga-image) was obtained 3 days after administration. Tumor vascular patterns were classified histopathologically into three groups ; rich, intermediate and poor. VR,BPR,early image, Ga-image, vascular pattern and tumor size were compared each other. Poor vascular pattern showed small VR (M(]SY.+-。[)SD=0.97(]SY.+-。[)0.08) and BPR (1.02(]SY.+-。[)0.04). Rich vascular pattern showed large VR (1.39(]SY.+-。[)0.01) and BPR (1.31(]SY.+-。[)0.16). Positive early image was predominant among large VR (78%) and BPR (100%). Tumors of under 3 cm in size showed that 65% of them belonged to intermediate or rich vascular pattern and positive early image reflected tumor blood flow. These results intimated the improvement of detecting ratio by combining early image (blood flow image) with delayd image.

在动物实验中，对右股骨区移植了VX2癌的日本白兔进行了组织学、血管造影和流体动力学检查，发现肿瘤血管随着肿瘤的生长以及血液流速和血流量而变得丰富。临床检查中，超声血流计（5 MHz）显示肿瘤侧的右股动脉约为对照侧（左股动脉）的两倍或三倍。给予<@D199m@>D1Tc-HMDP后立即对117名口腔癌患者进行闪烁照相检查和组织病理学评估。静脉相（给药后30至40秒）和血池相（1至3秒）的放射性。分钟）计算两个阶段肿瘤与对照区域的放射性比值（VR）、血池比值。 (BPR)。施用后5分钟获得<@D199m@>D1Tc-HMDP的早期图像(早期图像)，施用后3天获得<@D167@>D1Ga-柠檬酸盐的图像(Ga-图像)。组织病理学上将血管形态分为三组：VR、BPR、早期图像、Ga图像、血管形态和肿瘤大小进行比较。小 VR (M(]SY.+-. [)SD=0.97(]SY.+-.[)0.08) 和 BPR (1.02(]SY.+-.[)0.04)。丰富的血管图案显示较大的 VR (1.39(]SY.+-.[)0.01)。 ) 和 BPR (1.31(]SY.+-.[)0.16)。在大型 VR (78%) 和 BPR 中，阳性早期图像占主导地位。 (100%)小于3cm的肿瘤，65%属于中等或丰富血管型，早期图像反映肿瘤血流，这些结果表明结合早期图像(血流图像)可以提高检出率。）与延迟图像。