Histologic and Hydrodynamic Evaluation of Blood Flow for Scintigraphic Detection of Malignant Tumor of the Head and Neck.

头颈部恶性肿瘤闪烁显像检测中血流的组织学和流体动力学评估。

基本信息

批准号：
07672052
负责人：
SATO Tsuyoshi
金额：
$ 1.28万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
1995
资助国家：
日本
起止时间：
1995 至 1996
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-07672052/
关键词：
Scintigraphy Early image Malignant tumor Blood flow Head and Neck Scintigrashy Blood flow

项目摘要

In the experiment with animals, Japan white rabbits transplanted with VX2 carcinoma in the right femoral regionwere examined histologically, angiographically and hydrodynamically. The tumor blood vessel became rich in accordance with tumor growth and the blood flow rate and the volume of the blood flow of the right femoral artery in the tumor side was approximately twice or three times as much as that in the control side (left femoral artery) by means of the ultrasonic blood flow meter (5 MHz). In the clinical examination, 117 patients with oral cancer were examined scintigraphically and histopathologically. Tumor blood flow was estimated scintigraphically immediately after administration of <@D199m@>D1Tc-HMDP.Radioactivity of venous phase (30 to 40 seconds after administration) and blood pool phase (1 to 3 minutes) were observed. Radioactive ratios of tumor to the control region in both phases were calculated ; venous ratio (VR), blood pool ratio (BPR). Early image with <@D199m@>D1Tc-HMDP (early image) was obtained 5 minutes after administration and the image with <@D167@>D1Ga-citrate (Ga-image) was obtained 3 days after administration. Tumor vascular patterns were classified histopathologically into three groups ; rich, intermediate and poor. VR,BPR,early image, Ga-image, vascular pattern and tumor size were compared each other. Poor vascular pattern showed small VR (M(]SY.+-。[)SD=0.97(]SY.+-。[)0.08) and BPR (1.02(]SY.+-。[)0.04). Rich vascular pattern showed large VR (1.39(]SY.+-。[)0.01) and BPR (1.31(]SY.+-。[)0.16). Positive early image was predominant among large VR (78%) and BPR (100%). Tumors of under 3 cm in size showed that 65% of them belonged to intermediate or rich vascular pattern and positive early image reflected tumor blood flow. These results intimated the improvement of detecting ratio by combining early image (blood flow image) with delayd image.

在对动物的实验中，日本白兔子在右股骨区域中用VX2癌移植的日本兔子在组织学，血管造影和流体动力学上检查。肿瘤血管根据肿瘤的生长和血液流量和肿瘤侧右股动脉的血流量变得富含，大约是对照侧（左股动脉）的两倍或三倍，是超声血液流量计（5 MHz）。在临床检查中，从历史上和历史上检查了117例口腔癌患者。在给药<@d199m@> d1tc-hmdp.D1TC-HMDP。静脉相位（给药后30至40秒）和血池期（1至3分钟）后，立即估计肿瘤血流。计算了两个阶段中肿瘤与对照区域的放射性比。静脉比（VR），血池比率（BPR）。使用<@d199m@> D1TC-HMDP（早期图像）的早期图像是在给药后5分钟获得的，并且在给药后3天获得了带有<@d167@> d1ga-citrate（Ga-image）的图像。肿瘤血管模式在组织病理学上分为三组；富人，中级和贫穷。比较VR，BPR，早期图像，GA形象，血管模式和肿瘤大小。较差的血管模式显示了小VR（M（]SY。+ - 。[）SD = 0.97（]SY。+ - 。[）0.08）和BPR（1.02（]SY。+ - 。[）0.04）。丰富的血管模式显示了较大的VR（1.39（] SY。+ - 。[）0.01）和BPR（1.31（]SY。+ - 。[）0.16）。在大型VR（78％）和BPR（100％）中，阳性早期图像占主导地位。大小不足3 cm的肿瘤表明，其中65％属于中间或丰富的血管模式，正面图像阳性反映了肿瘤血流。这些结果通过将早期图像（血流图像）与延迟图像相结合，暗示了检测比的改善。