Lymphoscintigraphy with radio-colloidal agent

使用放射性胶体剂进行淋巴闪烁扫描

• 批准号: 17591970
• 负责人: SATO Tsuyoshi
• 金额: $ 2.24万
• 依托单位: Kagoshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591970/
• 关键词: lymph node; scintigram; radio-colloid; PET; 悪性腫瘍

(Materials ＆ Methods) Patients with oral cancer were examined by the scintigraphy with Tc-radio-colloid and PET with FDG. To detect lymph node metastasis, lymphoscintigraphy and PET scan were performed. In lymphoscintigraphy, two areas of injection were selected. One is the extra-oral subcutaneous area behind the ear for the cervical lymph nodes. The other is the intra-oral sub mucosal area of mucobuccal fold of the upper molar region for the submandibular lymph nodes. The radio-colloid in each volume of 0.25 ml (37MBq) was injected in both sides of each area respectively. Scanning was done immediately after injection with Gamma camera. In PET, FDG of 3.7MBq/kg was injected intravenously and the scanning was done after 40 min from the injection. Furthermore, the tumor samples, obtained either after the biopsy or after the operation, were embedded in paraffin wax and cut into thin sections for the immunohistochemical staining of the glucose transpototer. The accumulation of the lymph no … More des was evaluated into three groups and in PET scanning was evaluated into three grades respectively. The immunohistochemical staining was also evaluated into three grades visually. (Results) In PET scanning, around 75% of metastatic lymph nodes were detected. But, the detection strongly depended upon the size of lymph nodes and small lymph nodes were hardly detected (under 5%). The SUV ranged from 2 to 6 among lymph nodes and distributed widely. In lymphoscintigraphy, metastatic lymph nodes showed three images of defect, mottled and rope-like appearances. These images showed a close correlation with the pathologic manifestations respectively. In immunohistochemical staining of the glucose transporter, all metastatic lymph nodes showed from a moderate to a severe staining. (Conclusions) Lymphoscintigraphy with radio-colloida: agent and PET scanning with FDG were useful for the detection of metastatic lymph nodes of relatively large size. However, these methods were helpless for the small metastatic lymph nodes. Therefore, we will make a further evaluation to establish a technique for the detection of the small metastatic lymph nodes. Less

（材料与方法）通过TC-Radio-Colloid和FDG的PET检查口腔癌患者。为了检测淋巴结转移，进行了淋巴含量和PET扫描。在淋巴镜术中，选择了两个注射区域。一个是宫颈淋巴结耳朵后面的异常皮下区域。另一个是下颌下淋巴结的上摩尔区域的粘膜褶皱的口腔内粘膜区域。分别在每个区域的两侧注入了每个体积的0.25 mL（37MBQ）中的无射线。用伽马相机注射后立即进行扫描。在PET中，静脉注射3.7MBQ/kg的FDG，并在40分钟后从注射中进行扫描。此外，将活检后或手术后获得的肿瘤样品嵌入石蜡中，并切成薄切片，以进行葡萄糖转子的免疫组织化学染色。淋巴No的积累……将更多的DES评估为三组，并分别评估了三个年级。免疫组织化学染色也被视觉评估为三个级。 （结果）在PET扫描中，检测到约75％的转移性淋巴结。但是，几乎无法检测到淋巴结和小淋巴结的大小（低于5％）的检测。 SUV在淋巴结中的2到6不等，分布广泛。在淋巴细胞学中，转移性淋巴结显示了三张缺陷，斑驳和绳状外观的图像。这些图像分别显示与病理表现密切相关。在葡萄糖转运蛋白的免疫组织化学染色中，所有转移性淋巴结都从现代染色到严重的染色。 （结论）带有无线电胶体的淋巴含量：用FDG扫描药物和PET扫描可用于检测相对较大的转移性淋巴结。但是，对于小型转移性淋巴结，这些方法是无助的。因此，我们将进行进一步的评估，以建立一种检测小型转移性淋巴结的技术。较少的