Expression of Permeability-glycoprotein (P-gp) and Uptake of Technetium-99m-Hexakis-2-Methoxy-Isobutyl-Isonitrile (Tc-99m-MIBI) in Malignant Tumor of the Head and Neck

头颈部恶性肿瘤中渗透性糖蛋白（P-gp）的表达和Technetium-99m-Hexakis-2-甲氧基异丁基异腈（Tc-99m-MIBI）的摄取

基本信息

批准号：
13671972
负责人：
SATO Tsuyoshi
金额：
$ 0.64万
依托单位：
Kagoshima University
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2001
资助国家：
日本
起止时间：
2001 至 2003
项目状态：
已结题

项目摘要

(Clinical evaluation) As for the retention index (delayed uptake / early uptake), 99m-Tc-MIBI showed the retention index of under 1 (mean ± SD = 0.853 ± 0.067) in malignant tumor, indicating a tendency of decreasing in the delayed uptake. On the other hand, the retention indexes of 201-TlCl scintigraphy were classified into three groups according to histopathological types of tumor ; 0.81 ± 0.06 in benign tumors, 1.01 ± 0.10 in well differentiated malignant tumors, 1.09 ± 0.13 in moderately differentiated tumors, and 1.24 ± 0.14 in poorly differentiated tumors. Thus, the mean retention indexes were under 1 in benign tumor, but over 1 in malignant tumor. The higher the histopathological grade was, the larger the retention index became.(Accumulation mechanism) As for the relationship between P-gp expression (score 0, 1 and 2) and histopathological type of tumor, the scores (mean ± SD) = 0.75 ± 0.19 in benign tumors, 0.71 ± 0.36 in well differentiated tumor, 0.83 ± 0.40 in moderately differentiated tumor, and 1.60 ± 0.24 in poorly differentiated tumor. Thus, the mean score of P-gp expression was small in the benign or low-grade malignant tumor, but large in the high-grade malignant tumors. Comparing of Na, K-ATPase expression (score 0, 1 and 2) to the histopathological type of tumor, the scores (mean) = 0.82 in well differentiated tumor, 1.44 in moderately differentiated tumor, and 1.50 in poorly differentiated tumors respectively.(Conclusion) 99m-Tc-MIBI and 201-TlCl scintigraphy showed different tendency of delayed uptake, and accurate diagnosis of tumor could be obtained by using both 99m-Tc-MIBI and 201-TlCl scintigraphy. P-gp and Na, K-ATPase expression were observed in accordance with the results of 99m-Tc-MIBI and 201-TlCl scintigraphy.

（临床评估）对于保留指数（延迟吸收 /早期摄取）3±0.067）在恶性肿瘤中，表明延迟吸收的趋势是延迟吸收的趋势。在良性肿瘤中，在良好的恶性肿瘤中，在良性肿瘤中为1.01±0.10，在良好的分化肿瘤中为1.09±0.13，在良好分化较差的肿瘤中为1.24±0.14。恶性肿瘤。在良好的分化肿瘤中±0.36，中等分化的肿瘤中的0.83±0.40，较差的分化肿瘤中的1.60±0.24。 Na，K-ATPase Express（评分0、1和2）的级别肿瘤与肿瘤的组织病理学类型（平均值）= 0.82，分别是分化良好的肿瘤和1.50结论）99M-TC-MIBI和201-TLCL闪烁显像显示延迟摄取的趋势，可以通过使用99m-TC-MIBI D 201-TLCL闪烁显像，对肿瘤进行准确的诊断。根据99m-TC-MIBI和201-TLCL闪烁显像的结果观察到。