Disease models and novel diagnostic imaging markers

疾病模型和新型诊断成像标志物

• 批准号: 525876353
• 负责人: Professor Dr. Marcus R. Makowski
• 金额: --
• 依托单位: Institut für diagnostische und interventionelle Radiologie
• 依托单位国家: 德国
• 项目类别: Clinical Research Units
• 资助国家: 德国
• 项目状态: 未结题
• 来源: https://gepris.dfg.de/gepris/projekt/525876353?language=en
• 关键词: Disease; models; novel; diagnostic; imaging

This project aims at the development of novel non-invasive ways to detect and monitor synaptic damage in the context of synaptic dysfunction. Novel autoantibodies/-fragments generated within the consortium from patient-derived immune cells will be used to generate mouse models of neuropsychiatric disease by intracerebral or systemic antibody injections. The models will be used to validate entirely new compounds based on autoantibodies labelled with iron/gadolinium complexes. The engineered antibodies may allow the in vivo visualization of synaptic changes. The central question of this project is how newly developed antibody-based imaging probes can be utilized for the in vivo visualization and quantification of synaptic dysfunction by molecular magnetic resonance.

该项目旨在开发新型非侵入性方法来检测和监测突触功能障碍情况下的突触损伤。该联盟内从患者来源的免疫细胞中产生的新型自身抗体/片段将用于通过脑内或全身抗体注射来产生神经精神疾病的小鼠模型。这些模型将用于验证基于铁/钆复合物标记的自身抗体的全新化合物。工程化抗体可以实现突触变化的体内可视化。该项目的核心问题是如何利用新开发的基于抗体的成像探针通过分子磁共振对突触功能障碍进行体内可视化和量化。