Studies on Anticancer Substances in Ethnic Crude Drugs and Unused Medicinal Resources of East Africa

东非民族生药及未利用药材资源中抗癌物质研究

• 批准号: 05042007
• 负责人: KATO Atsushi
• 金额: $ 4.48万
• 依托单位: Kobe Women's College of Pharmacy
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for international Scientific Research
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-05042007/
• 关键词: Anticancer substance; Mitogenic activity; Rhizophoraceae; Antipromotin on EB-virus activation; Triterpenoid; Meliaceae; African ethnic crude drug; Sulfur containing alkaloid

Many naturally occurring anticancer substances have isolated from plants and marine products, and also their chemical modifications tried for further effect and safety as medicine in various institutes. Some these compounds are used as clinical medicines. More study on anticancer substance in natural resources is desired at present. Therefore, in order to find new anticancer substances in the tropical plants, the field researches in East Africa, especially, in Kenya, Tanzania and Madagascar were carried out by us in 1993.For selection of collecting plants, we have adapted an approach to traditional medicines of tribes and unused medicinal resources.A total of 110 species of plants was collected during the research. Among these plants, some species have been tried to test physiological activities, and were expected to exhibit anticancer activity from results of first screening tests such as an inhibition test on EB-virus activation, a stimulation index on human peripheral blood lymphocytes and mouse spleen lymphocytes and a growth inhibition of HGC-27 cells.For the other species, a screening test related to anticancer activity will be done to find useful natural products from the plants.

许多天然存在的抗癌物质已从植物和海产品中分离出来，并且各个研究所也尝试对其进行化学修饰以提高其作为药物的效果和安全性。这些化合物中的一些被用作临床药物。目前需要对自然资源中的抗癌物质进行更多的研究。因此，为了在热带植物中寻找新的抗癌物质，我们于1993年在东非，特别是肯尼亚、坦桑尼亚和马达加斯加进行了实地研究。在采集植物的选择上，我们采用了传统的方法。研究期间共采集了110种植物。在这些植物中，一些物种已尝试测试生理活性，并且根据首次筛选测试的结果，例如EB病毒激活的抑制测试、人外周血淋巴细胞和小鼠脾淋巴细胞的刺激指数，预计显示出抗癌活性对HGC-27细胞的生长抑制。对于其他物种，将进行与抗癌活性相关的筛选测试，以从植物中寻找有用的天然产物。

项目成果

ATSUSHI KATO: "Examination of Alkaloidal Constituents of Zanthoxylum usambarense by the Combination of Ion-pair Extraction and Ion-pair Chromatography Using Sodium Perchlorate" Phytochem. Anal.(preparation).

ATSUSHI KATO：“通过使用高氯酸钠的离子对萃取和离子对色谱相结合来检查花椒的生物碱成分”Phytochem。

加藤 篤: "Inhibition by some African Traditional Medicines of the Tumor-Promotion Activity of TPA in Mouse-Skin Carcinogensis" Int.J.Cancer. (予定).

Atsushi Kato：“一些非洲传统药物对小鼠皮肤致癌作用中 TPA 的肿瘤促进活性的抑制”Int.J.Cancer（计划中）。

ATSUSHI KATO: "Inhibition by some African Traditional Medicines of the Tumor-Promotion Activity of TPA in Mouse-Skin Carcinogensis" Int.J.Cancer. (preparation).

ATSUSHI KATO：“一些非洲传统药物对 TPA 在小鼠皮肤致癌作用中的肿瘤促进活性的抑制”Int.J.Cancer。

ATSUSHI KATO: "Mitogenic Activities in African Traditional Herbal Medicines" Planta Med.59. 354-358 (1993)

ATSUSHI KATO：“非洲传统草药中的促有丝分裂活性”Planta Med.59。

加藤 篤: "Studies on Structure of Sulfure Containing Alkaloids from Cassipourea spp.in Africa and Anti-Tumor-Promoting Activities of Isolated Compounds" Int.J.Cancer. (予定).

Atsushi Kato：“非洲 Cassipourea spp. 含硫生物碱的结构和分离化合物的抗肿瘤促进活性的研究”Int.J.Cancer（计划）。