Synthesis of Tn and Sialyl Tn Antigen-Lipid A Analog Conjugate for Synthetic Vaccines

用于合成疫苗的 Tn 和唾液酸 Tn 抗原-脂质 A 类似物缀合物的合成

• 批准号: 08672565
• 负责人: IKEDA Kiyoshi
• 金额: $ 1.22万
• 依托单位: University of Shizuoka
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1996
• 资助国家: 日本
• 起止时间: 1996 至 1997
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-08672565/
• 关键词: synthetic vaccines; lipid A analogue; mitogenic activity; synthetic immunoad juvat; antitumor antigen; HIV antigen; リピドA類緑体; リピドA; L-セリン誘導体

We synthesized the completely synthetic vaccines based on tumour- and HIV-associated carbohydrate and peptide antigens having N-tetradecanoyl L-seryl-beta-alanine-containing D-glucosamine derivatives structurally related to lipid A as efficient synthetic immunoadjvants. These synthetic vaccines showed potent immunogenic activities.

我们基于肿瘤和HIV相关的碳水化合物和肽抗原的完全合成疫苗，具有N-四核L-seryl-beta-亚甲烷 - 丙氨酸 - 丙氨酸 - 丙氨酸 - 丙氨酸 - 丙氨酸衍生物，该衍生物在结构上与脂质A作为有效的合成免疫剂的结构相关。这些合成疫苗显示出有效的免疫原性活性。

项目成果

Keisuke Miyajima: "Synthesis and Structure -activity Relationships N-Acylated L-Serine or L-Threonine-containing D-Glucosamine Derivatives imicks of Lipid Disacchar de" Chem.Pharm.Bull.45. 1089-1093 (1997)

Keisuke Miyajima：“模拟脂质二糖的 N-酰化 L-丝氨酸或 L-苏氨酸 D-葡萄糖胺衍生物的合成和结构-活性关系”Chem.Pharm.Bull.45。

Tadayori Shimizu: "Comparison with Biological Activties of Synthetic Lipid A Analogs Linked N-Acylated Asparagine or Serine" Immunobiol.195. 321-333 (1996)

Tadayori Shimizu：“与 N-酰化天冬酰胺或丝氨酸连接的合成脂质 A 类似物的生物活性比较”Immunobiol.195。

Keisuke Miyajima, Noriaki Gomi, Kiyoshi Ikeda, and Kazuo Achiwa: "Lipid A and Related Compounds. XXXIII.Synthesis and Structure-activity Relationships of N-Acylated L-Serine or L-Threonine-containing D-Glucosamine Derivatives Mimicks of Lipid A Disacchari

Keisuke Miyajima、Noriaki Gomi、Kiyoshi Ikeda 和 Kazuo Achiwa：“脂质 A 和相关化合物。XXXIII.N-酰化 L-丝氨酸或 L-苏氨酸含有 D-葡萄糖胺衍生物模拟脂质 A 二糖的合成和结构-活性关系

Kiyoshi Ikeda: "Synthesis of Biologically Active N,N-Diacyl Chitobiose Derivatives Structurally Related to Lipid A" Chem.Pharm.Bull.44. 1958-1961 (1996)

Kiyoshi Ikeda：“与脂质 A 结构相关的生物活性 N,N-二酰基壳二糖衍生物的合成”Chem.Pharm.Bull.44。

Keisuke Miyajima: "Lipid A and Related Compounds.XXXIII. Synthesis and Structure-activity Relationships of N-Acylated L-Serine or L-Threonine containing D-Glucoasamine Derivatives Limicks of Lipid A Disaccharide" Chem.Pharm.Bull.45. 1089-1093 (1997)

Keisuke Miyajima：“脂质A和相关化合物.XXXIII.含有脂质A二糖的D-葡萄糖胺衍生物Limiks的N-酰化L-丝氨酸或L-苏氨酸的合成和结构活性关系”Chem.Pharm.Bull.45。