Chemoenzymatic synthesis of N-acetylneuraminic acid derivatives and their behaviour towards sialidase from human parainfluenza virus

N-乙酰神经氨酸衍生物的化学酶合成及其对人副流感病毒唾液酸酶的行为

• 批准号: 13672223
• 负责人: IKEDA Kiyoshi
• 金额: $ 1.66万
• 依托单位: University of Shizuoka
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2001
• 资助国家: 日本
• 起止时间: 2001 至 2002
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-13672223/
• 关键词: sialic acid; parainfluenza sialidase; sialidase inhibitor; hybrid-process; 2-deoxy-2, 3-dehydro-sialic acid; 2, 2-difluorosialic acid derivatives; シアリダーゼ阻害活性; アドラーゼ; 2-デオキシ-2,3-デヒドロシアル酸

Human parainfluenza virus is an important human pathogen causing upper and lower respiratory disease. To explore the influence on binding to sialidase from hPIV-1, modification of the hydroxyl group at the C-4 in 2β, 3β-difluorosialic acid derivatives and Neu5Ac2en derivatives was carried out. Synthesized compounds showed inhibitory activities against hPIV-1.

人副parainfluenza病毒是一种重要的人类病原体和下呼吸道疾病。曾经进行过，是由合成的化合物表现出对HPIV-1的抑制作用。

项目成果

Kiyoshi Ikeda et al.: "Use of Phenyl 2-a-Selenoglycosides of N-Acetylneuraminic Acid as a Glycosyl Donor for the Glycosylation Reactions"Bioorg. Med. Chem. Lett.. 12. 2309-2311 (2002)

Kiyoshi Ikeda 等：“N-乙酰神经氨酸的苯基 2-a-硒代糖苷作为糖基化反应的糖基供体的用途”Bioorg。

Masaki Ito et al.: "An Improved Fluorometric High-Performance Liquid Chromatography Method for Sialic Acid Determination An Internal Standard Method and Its Application to Sialic Acid Analysis of Human Apolipoprotein"Anal. Biochem.. 300. 260-266 (2002)

Masaki Ito 等人：“一种改进的荧光高效液相色谱法测定唾液酸内标法及其在人载脂蛋白唾液酸分析中的应用”

Masaki Ito et al.: "An Improved Fluorometic High-Performance Liquid Chromatography Method for Sialic Acid Determination : An Internal Standard Method and its Application to Sialic Acid Analysis of Human Apolipoprotein E"Anal. Biochem.. 300. 260-266 (2002)

Masaki Ito 等人：“一种改进的荧光高效液相色谱法测定唾液酸：内标法及其在人载脂蛋白 E 唾液酸分析中的应用”Anal。

Takashi Suzuki., Kiyoshi Ikeda., Noriko Koyama., Chika Hosokawa., Toshihiro Kogure., Tadanobu Takahashi., Kazuya I. -P Jwa Hidari., Daisei Miyamoto., Kiyoshi Tanaka., and Yasuo Suzuki.: "Inhibition of Human Parainfluenza Virus Type 1 Sialidase by Analogs

Takashi Suzuki.、Kiyoshi Ikeda.、Noriko Koyama.、Chika Hosokawa.、Toshihiro Kogure.、Tadanobu Takahashi.、Kazuya I. -P Jwa Hidari.、Daisei Miyamoto.、Kiyoshi Tanaka. 和 Yasuo Suzuki.：“人类的抑制

Masaki Ito., Kiyoshi Ikeda., Yuki Suzuki., Kiyoshi Tanaka., and Megumi Saito.: "An Improved Fluorometric High-Performance Liquid Chromatography Method for Sialic Acid Determinatin: An Internal Standard Method and Its Application to Sialic Acid Analysis of

Masaki Ito.、Kiyoshi Ikeda.、Yuki Suzuki.、Kiyoshi Tanaka. 和 Megumi Saito.：“改进的唾液酸测定荧光高效液相色谱方法：内标法及其在唾液酸分析中的应用”