Molecular Design of Specialty Polymers Carrying Oligosaccharide Chains as Cell Recognition Signals

携带寡糖链作为细胞识别信号的特种聚合物的分子设计

• 批准号: 01550715
• 负责人: KOBAYASHI Kazukiyo
• 金额: $ 1.15万
• 依托单位: Nagoya University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1989
• 资助国家: 日本
• 起止时间: 1989 至 1990
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-01550715/
• 关键词: Biomedical Meterials; Glyco Engineering; Molecular Recognition; Ringーopening Polymerization; Synthetic Polysaccharides; Oligosaccharide; Carbohydrate-Carrying Polymers; Cell-Specific Materials

We have given attention to oligosaccharide chains as the key parti,cipants in cell-cell recognitions of various biological events. Well-defined polymers having oligossaccharide chains should serve as cellーspecific biomedical materials. Following six types of polymers having galactose, mannose, N-aceylglucosamine, and glucose residues as recognition markers have been synthesized.(1) Oligomers of lactose-substituted styrene monomer. Via radical telomerization.(2) Homopolymer of N-acetylchito-oligosaccharide substituted styrene. Via redical polymerizaton of macromonomer.(3) Star-type graft copolymers. Via radical polymerization of macromer from sugar-carrying methyl=methacrylate monomer.(4) Comb-shaped branched polysaccharides, 4-O-(alpha-D-mannopyranosyl)-(1->6)-alpha-D-mannopyranan. Via ring-opening polymerization of anhydro disaccharide derivatives.(5) (1->6)-beta-D-Galactopyranan. Via steric control by neighboring-group participation in ring-opening polymerization.(6) Oligosaccharide-carrying polypeptides. Via polymeric reaction of poly (L-glutamic acid).

我们关注寡糖链作为细胞间识别各种生物事件的关键参与者，具有寡糖链的明确聚合物应作为细胞特异性的生物医学材料，其中包含半乳糖、甘露糖、N 的六种类型的聚合物。合成了β-乙酰氨基葡萄糖和葡萄糖残基作为识别标记。(1)乳糖取代苯乙烯单体的低聚物。 (2) N-乙酰壳寡糖取代苯乙烯的均聚物，通过大分子单体的自由基聚合。(3) 通过携带糖的甲基丙烯酸甲酯单体的星型接枝共聚物。支链多糖， 4-O-(α-D-吡喃甘露糖基)-(1->6)-α-D-吡喃甘露聚糖通过脱水二糖衍生物的开环聚合得到。(5) (1->6)-β-D-吡喃半乳糖。通过邻近基团参与开环聚合的空间控制。(6)通过聚合的寡糖多肽。聚（L-谷氨酸）的反应。

项目成果

小林 一清: "新しい血小板粘着阻止材料の分子設計" 化学工業. 41. 312-315 (1990)

Kazukiyo Kobayashi：“新型血小板粘附抑制材料的分子设计” Kagaku Kogyo。 41. 312-315 (1990)

K.Kobayashi: "Synthesis of an NーAcetylchito OligosaccharideーCarrying StyreneーType Macromer and Its Homopolymer" Makromol.Chem.,Rapid Commun.11. (1990)

K.Kobayashi：“N-乙酰壳寡糖携带苯乙烯型大分子单体及其均聚物的合成”Makromol.Chem.，Rapid Commun.11（1990）。

小林一清: "木材から人工臓器をつくる" 木材工業. 44. 8-12 (1989)

Kazukiyo Kobayashi：“用木材制造人造器官”《木材工业》44. 8-12 (1989)。

K.Kobayashi: "Regioselectively Modified Stereoregular Polysaccharides.XIII. Polymerization of 3-Deoxygenated 1,6-Anhydro-glucopyranose Derivative" Polymer J.21. 137-146 (1989)

K.Kobayashi：“区域选择性改性的立体规则多糖。XIII.3-脱氧1,6-脱水-吡喃葡萄糖衍生物的聚合”聚合物J.21。

小林 一清: "長鎖アルキル基をもつ多糖の合成と機能" 油化学(「糖脂質」小特集). (1991)

Kazukiyo Kobayashi：“长链烷基多糖的合成和功能”石油化学（“糖脂”小特刊）（1991）。