3-dimensional Analysis for Conduction Blocks of the Spinal Cord with Multi-channel Superconducting Quantum Interference Device.

利用多通道超导量子干涉装置对脊髓传导块进行三维分析。

• 批准号: 11557109
• 负责人: FUJIMOTO Yoshinori
• 金额: $ 8.58万
• 依托单位: Hiroshima University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B).
• 财政年份: 1999
• 资助国家: 日本
• 起止时间: 1999 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-11557109/
• 关键词: Spinal Cord Magnetic Field; Superconduction Quantum Interference Device; SQUID; Spinal Cord

The magnetic filed measurement of the spinal cord has theoretical advantages of high spatial resolution compared with the conventional electric potential measurement. The purpose of this study was to measure the magnetic field of the spinal cord and to examine three-dimensional conduction blocks of the cord with superconduction quantum interference device (SQUID). The highly sensitive SQUID was designed for detection of the fine magnetic fields from the spinal cord. A gradiometer system with two SQUID coils was produced for the study. Also a small shield room was designed and produced to intercept outside magnetic noise and the SQUID system were placed within the shield room. An operation table was placed on a movable plastic gantry. The sciatic nerve of a cat was stimulated electrically and evoked magnetic fields produced in the spinal cord were measured at the thoracic and the lumbar spine. Evoked magnetic fields at the upper lumbar spine could be measured by sciatic nerve stimulation. The magnetic field measurement with the SQUID could diagnose the conduction blocks and was useful for the analysis of the spinal cord function.

与传统的电位测量相比，脊髓的磁场测量具有空间分辨率高的理论优势。本研究的目的是测量脊髓的磁场，并用超导量子干涉装置（SQUID）检查脊髓的三维传导块。高灵敏度 SQUID 专为检测脊髓的精细磁场而设计。为了这项研究，我们制作了一个带有两个 SQUID 线圈的梯度计系统。还设计并制作了一个小型屏蔽室来拦截外部磁噪声，并将SQUID系统放置在屏蔽室内。手术台放置在可移动的塑料龙门架上。对猫的坐骨神经进行电刺激，并在胸椎和腰椎处测量脊髓中产生的诱发磁场。上腰椎诱发的磁场可以通过坐骨神经刺激来测量。 SQUID 的磁场测量可以诊断传导阻滞，有助于分析脊髓功能。

项目成果

藤本吉範: "脊髄髄内腫瘍に対する脊髄機能モニタリング"脊髄電気診断学 別冊. 21・1. 68-71 (1999)

藤本义德：“髓内肿瘤的脊髓功能监测”《脊髓电诊断特卷》21・1（1999）。

藤本吉範: "脊髄疾患に対するモニタリングの有用性-各種誘発電位を用いて-"中部整災誌. 42. 1253-1254 (1999)

Yoshinori Fujimoto：“监测脊髓疾病的有用性 - 使用各种诱发电位 -”中部灾害管理杂志 42. 1253-1254 (1999)。