No Invasive Methods For Bone quality Using Superconduction Quantum Interference Device

利用超导量子干涉装置无创监测骨质量

• 批准号: 10671374
• 负责人: KIM Wook-cheol
• 金额: $ 2.05万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 1998
• 资助国家: 日本
• 起止时间: 1998 至 2000
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-10671374/
• 关键词: SQUID; Electrical current route; Electrical stimulation; Alternating current; Callus maturation; 骨折治癒; 仮骨形成促進; SQUID; microfracture; electromagnetic field; fracture healing

We tried to measure a reactive electricmagnetic field of a leg in rabbit after pulsing electromagnetic stimulation (10, 20, 30 Gaus, 2Hz) using Superconduction Quantum Interference Device. However, we had a lot of noise composed of the pulsing electromagnetic field, reactive magnetic field from soft tissues (nerve, muscle etc.), Therefore, we can not detect the reactive magnetic field from bone tissue. Next we try to evaluate the impedance of bone tissue in the process of callus formation. We used lengthend callus of tibiae in 30 rabbits. Thirty Japanese white rabbits were divided into 3 groups : Group ES (early stimulation ; Alternating stimulation from just after operation), Group LS (late stimulation ; electrical stimulation from 3 weeks after operation) Group C (control). The waiting period was 1 week and the lengthening rate was 0.5mm twice daily. Radiological, histological, and electrophysiological studies were done on animals sacrificed at 2 weeks after the completion of lengthening. Radiologically in groups ES and LS, corticalization and medullarization began earlier than in group C.The values of bone mineral density of the lengthened callus in groups ES and LS were significantly decreased as compared with those in group C.The impedance values for the resected tibia in group ES were significantly increased, as compared to those in group C.The impedance values of resected tibia increased with the maturation of the lengthened callus. When electrical current route was composed of bone and soft tissue as a simple parallel circuit, we considered that about 64% of the whole electrical current passed through bone tissue. Alternating current electrical stimulation to the lengthened callus was useful for remodeling of the mineralized callus, and the impedance of lengthened callus reflected the maturation itself.

我们尝试使用超导量子干涉装置测量脉冲电磁刺激（10、20、30 高斯、2Hz）后兔子腿部的反应电磁场。然而，我们有很多由脉冲电磁场​​、来自软组织（神经、肌肉等）的反应磁场组成的噪声，因此，我们无法检测来自骨组织的反应磁场。接下来我们尝试评估骨组织在骨痂形成过程中的阻抗。我们在 30 只兔子身上使用了延长胫骨愈伤组织。 30只日本白兔分为3组：ES组（早期刺激；术后即刻交替刺激）、LS组（晚期刺激；术后3周起电刺激）C组（对照）。等待时间为1周，延长速度为0.5mm，每天两次。对延长完成后两周处死的动物进行放射学、组织学和电生理学研究。影像学结果显示，ES组和LS组皮质化和髓质化开始早于C组。ES组和LS组延长骨痂的骨密度值较C组显着降低。切除胫骨的阻抗值ES组较C组明显增加。切除胫骨的阻抗值随着骨痂的成熟而增加。当电流路径由骨骼和软组织组成简单的并联电路时，我们认为大约有64%的总电流通过骨骼组织。对延长的愈伤组织进行交流电刺激对于矿化愈伤组织的重塑是有用的，并且延长的愈伤组织的阻抗反映了成熟本身。

项目成果

金 郁〓 ほか: "イリザロフ創外固定器を用いて一期的に偽関節手術と脚延長を行った1創" 日本創外固定・骨延長学会誌. 9. 141-146 (1998)

Ikuo Kim 等人：“使用 Ilizarov 外固定器用临时假关节和腿部延长治疗一处伤口”，《日本外固定和骨延长杂志》，9. 141-146 (1998)。

渡部欣忍,金郁哲 ほか: "アコースティック・エミッション法による骨癒合のモニタリングーイソザロフ創外固定法への応用"日本創外固定・骨延長学会誌. 9. 43-48 (1998)

Kinnobu Watanabe、Ikutetsu Kane 等人：“通过声发射法监测骨愈合 - 在 Isosarov 外固定方法中的应用”日本外固定和骨延长学会杂志 9. 43-48 (1998)。

平澤泰介監訳.ジョセフ.シャツカー マーヴィン・タイル著: "骨折-理論的治療と実際- (金郁〓共訳)" Springer-Verlag Benlin Heidelberg, Springer-Verlag Tokyo, 40 (1998)

由平泽泰辅监督翻译，约瑟夫·沙茨克 (Joseph Schatzker) 和马文·泰尔 (Marvin Tyle) 撰写：“骨折 - 理论治疗和实践 - (由 Iku Kim 共同翻译)” Springer-Verlag Benlin Heidelberg，Springer-Verlag Tokyo，40 (1998)

河本浩栄: "交流電気刺激による仮骨延長モデルの仮骨成熟に関する実験的研究"京都府立医科大学雑誌. 110. 35-47 (2001)

Koei Kawamoto：“使用交流电刺激的愈伤组织延长模型中愈伤组织成熟的实验研究”京都府立医科大学学报 110. 35-47 (2001)。

金郁ちょる、日下部虎夫、土田雄一、細川元男、河本*栄: "小児の長官骨変形矯正と骨延長における問題点"日本創外固定・骨延長学会雑誌. 10. 47-51 (1999)

Choru Kane、Torao Kusakabe、Yuichi Tsuchida、Motoo Hosokawa 和 Sakae Kawamoto：“儿童骨畸形和延长的问题”，日本外固定和骨延长学会杂志 10. 47-51 (1999)。