Clinical application of a biomagnetic measurement system with high temperature superconduction quantum interference device

高温超导量子干涉装置生物磁测量系统的临床应用

基本信息

批准号：
16590459
负责人：
NOMURA Masahiro
金额：
$ 2.24万
依托单位：
The University of Tokushima
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2004
资助国家：
日本
起止时间：
2004 至 2005
项目状态：
已结题

项目摘要

1)We evaluated whether the cardiac electrical current could be visualized by displaying the current density using a high temperature superconducting quantum interference device (high Tc-SQUID). Magnetic fields from heart were measured using a 32-channel high Tc-SQUID (Sumitomo Electric Hightecs, Co., Ltd.) in a magnetically shielded room. Vector currents were obtained at 32 lead points based on the magnetic gradient, and a current density map were constructed. Current electrical currents were clearly detected during depolarization and repolarization phases. Previously, the detection of magnetic field from the heart required an expensive SQUID system using liquid helium. However, this system was characterized-by its relative higher cost-effectiveness and excellent spatial resolution. In addition, few studies have been done on the map which displays cardiac current density, which can potentially provide important information on electromotive forces. Therefore, this system can be clinical … More ly applied because it facilitates the detection of detailed cardiac electrical current.2)We investigated whether an infarct vector that could not be deduced by electrocardiogram was detectable using isomagnetic and current density map of magnetocardiogram. Old inferior myocardial infarction (15 patients ; MI group) and normal healthy subjects (20 cases ; N group) were recorded with second derivative superconducting quantum interference device (SQUID) magnetocardiometer. Current vector magnitude of each 36 precordial recording point was calculated from magnetic field gradient of adjacent two points. Spline interpolation of precordial current distribution was performed and electromotive force of heart was estimated form current density map. In all subjects in the N group, the QRS vector at 30-40 msec after the onset of QRS wave was directed leftward and inferiorly and multiple dipoles could not be recognized from either surface electrocardiogram, or isomagnetic map. Moreover, in current density map of the ventricular depolarization phase in the N group, one current density was deduced. However, multiple current densities were deduced from the magnetocardiogram of the ventricular depolarization phase in the MI group unlike normal subject. That is, in inferior myocardial patient with abnormal Q wave, the QRS vector at 30-40 msec after the onset of QRS wave was directed superiorly in surface electrocardiogram. On the other hand, the superior QRS vector was deduced in isomagnetic map even in patients with non-Q wave inferior myocardial infarction. In the MI group, multiple current sources were suggested in 4 patients which did not be detected in body surface electrocardiogram. These results suggest that the ventricular depolarization vectors were composed of a normal dipole directed leftward and inferiorly, and an abnormal dipole directed superioly due to inferior myocardial infarction. It is concluded that magnetocardiogram can detect the infarct electromotive force which could not be deduced in electrocardiography. Less

1）我们评估了使用32通道高的TC-squid（Sumitomo Electric Hightecs，co，co，ltd。基于磁性梯度的铅构成的铅量清楚地检测到了液体液体的磁场，在地图上很少有研究表现出心脏电流密度，这可能会提供信息的元素力。记录了磁心电图的密度图（20例； n组）。心脏的估计形式的电流密度图。二元图或异磁图。 Q波异常的患者，在QRS波发作后，QRS载体在表面心电图中的QRS速率高于患者的患者中，在表面心电图中定向。在MI组中，心肌梗死。在身体表面心电图中未检测到4例未检测到的电流。二函可以检测无法在心电图中推导的梗塞电动力。

项目成果

期刊论文数量（15）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Detection of myocardial ischemic vector using current density map

使用电流密度图检测心肌缺血向量

DOI：
发表时间：
2005
期刊：
The Journal of Japan iomagnetism and Bioelectromagnetics Society 18(1)
影响因子：
0
作者：
Nomura M;Nakaya Y;Nakayasu K.
通讯作者：
Nakayasu K.

Visualization of cardiac electrical current using 32-channel high temperature superconducting quantum interference device

利用32通道高温超导量子干涉装置实现心脏电流可视化

DOI：
发表时间：
2004
期刊：
BIOMAG 2004
影响因子：
0
作者：
Yusuke Adachi;Ippei Motomura;Rie Ueda;Hiroyuki Yasui;Ayako Kiyomasu;Jitsuya Takada;Hiromu Sakurai;Nomura M
通讯作者：
Nomura M

心磁図法による心筋梗塞ベクトルの評価:心電図で捉えられない心起電力の検出

使用心磁图评估心肌梗塞向量：检测心电图无法捕获的心脏电动势