Early diagnosis of myocardial ischemia using magnetocardiogram

心磁图早期诊断心肌缺血

基本信息

批准号：
18590532
负责人：
NOMURA Masahiro
金额：
$ 2.51万
依托单位：
The University of Tokushima
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (C)
财政年份：
2006
资助国家：
日本
起止时间：
2006 至 2007
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-18590532/
关键词：
magnetocardiogram current density map abnormal electrical current isopotential map early diagnosis myocardial infarction ischemic vector myocardial ischemia

项目摘要

We investigated the issue of whether the current density map method, in which cardiac current is estimated from the magnetic gradient, facilitates the visualization of cardiac current undetectable by ECG.1) Evaluation of an infarction vectorOld inferior myocardial infarctions (MI group) and normal healthy subjects (Normal group) were recorded using magnetocardiometer. The electromotive force of the heart was estimated from a current density map. In the current density map of the ventricular depolarization phase, multiple current densities were deduced from magnetocardiograms of the ventricular depolarization phase in the MI group, unlike normal subjects. In 4 patients in the MI group, multiple current sources were suggested, which were not detected in a body surface electrocardiogram. Magnetocardiogram is capable of permitting infarct electromotive forces to be detected, which could not be deduced from electrocardiography data.2) Detection of cardiac current undetectable by electrocard … More iography using magnetocardiography in various cardiac diseasesThe subjects were 50 healthy adults (N group), 40 patients with left ventricular overloading (LVO group), 15 patients with right ventricular overloading (RVO group), 10 patients with an old inferior myocardial infarction (OMI group), and 30 patients with diabetes mellitus (DM group). MCGs were recorded with a second derivative superconducting quantum interference device (SQUID) gradiometer using liquid helium. Isopotential maps and current density maps from unipolar precordial ECG leads and MCGs, respectively, were prepared, and the cardiac electric current was examined. The current density map at the ventricular depolarization phase showed one peak of current density in the N group. However, in the OMI group, the current density map showed multiple peaks of current density areas. In the RVO group, two peaks of current densities were detected at the right superior region and left thoracic region and these two diploles appeared to be from the right and left ventricular derived cardiac currents, respectively. Moreover, there was a significant correlation between the magnitude of the current density from the right ventricle and the systolic pulmonary arterial pressure. The current density map at the ventricular repolarization phase in the N group showed only a single current source. However, abnormal current sources in the current density maps were frequently detected even in patients showing no abnormalities on isopotential maps in the LVO, DM, and OMI groups.Our results suggest that MCG with a current density map is useful for detecting cardiac current undetectable by ECG in an early stage. Less

我们研究了当前密度图法（从磁性梯度估算的心脏电流）是否有助于通过ECG估算心脏电流的可视化。1）使用磁质量计，记录了对梗塞载体载体下部心肌基础设施（MI组）的评估。心脏的电子力量是从电流密度图估计的。在心室去极化阶段的当前密度图中，与正常受试者不同，MI组的心室去极化阶段的磁心电图推导了多个电流密度。在MI组的4例患者中，提出了多个电流来源，在身体表面心电图中未检测到。掌上心电图能够允许检测到梗塞电动力，无法从心电图数据中推断出来。2）检测到心脏电流无法通过电压标记的心脏电流……在各种心脏疾病中使用磁心电图的更多心电图造影术更多受试者是50名健康成人（n组）患者，患者（n组40例），左心室过载（左心室）（15例），允许（LVO）（lvo）（lvo）（lvo）（lvo）（lvo）（lvO）（lvo）（lvo）（lvo）（lvo）（lvo）（lv）。组），10例患有旧的心肌梗死（OMI组）的患者和30例糖尿病患者（DM组）。使用液体氦的第二个导数超导量子干扰装置（Squid）梯度计记录MCG。分别制备了单极前端口ECG铅和MCG的同一地图和电流密度图，并检查了心脏电流。心室去极化阶段的电流密度图显示了N组电流密度的一个峰。但是，在OMI组中，当前密度图显示了当前密度区域的多个峰。在RVO组中，在右上角区域和左胸腔区域检测到当前密度的两个峰，这两个外交官似乎分别来自左右心室衍生的心脏电流。此外，右心室的电流密度的大小与收缩压肺动脉压之间存在显着相关性。 n组的心室复激阶段的电流密度图仅显示一个电流源。但是，即使在LVO，DM和OMI组中没有异常的患者中，也经常检测到当前密度图中的异常电流源。您的结果表明，具有电流密度图的MCG可用于检测ECG在早期阶段无法检测到ECG的心脏目前。较少的