Studies for clinical use of olfactory evoked potentials by electrical stimulating olfactory mucosa

电刺激嗅粘膜嗅觉诱发电位的临床应用研究

基本信息

批准号：
09470299
负责人：
KODAMA Namio
金额：
$ 6.53万
依托单位：
Fukushima medical university
依托单位国家：
日本
项目类别：
Grant-in-Aid for Scientific Research (B).
财政年份：
1997
资助国家：
日本
起止时间：
1997 至 2000
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-09470299/
关键词：
evoked potentials olfactory function electrical stimulation intraoperative monitoring olfactory mucosa

项目摘要

Following surgeon near the anterior fossa, some patients experience loss of olfactory functions. However, objective methods for evaluating olfactory functions, which are also important for daily living, have not yet been developed.The olfactory evoked potential (OEP) obtained by electrical stimulation of the olfactory mucosa was recorded in dogs and humans to develop an objective method for evaluating olfactory functions. In dogs, OEPs were recorded from the olfactory tract and the scalp. The latency of the first negative peak was approximately 40 msec. A response was not obtained following stimulation of the nasal mucosa and disappeared following sectioning of the olfactory nerve. With increasing frequencies of repetitive stimulation, the amplitude was reduced, suggesting that the response was synaptically mediated. These results demonstrate that evoked potentials from the olfactory tract and the scalp following electrical stimulation of the olfactory mucosa originate specifically from the olfactory system. In humans, a stimulating electrode with a soft catheter was fixed on the olfactory mucosa. The OEP from the olfactory tract was recorded with a negative peak at approximately 27 msec, similar to characteristics found in dogs. The OEP from the olfactory tract in humans also originates specifically from the olfactory system. The OEP obtained by electrical stimulation of the olfactory mucosa may prove useful for intraoperative monitoring of olfactory functions.

在前窝附近的外科医生之后，一些患者经历了嗅觉功能的损失。然而，尚未开发出对日常生活也很重要的评估嗅觉功能的客观方法。通过电刺激对狗和人类的嗅觉粘膜获得的嗅觉诱发潜力（OEP），以开发一种客观的方法来开发一种评估嗅觉功能的客观方法。在狗中，从嗅觉和头皮记录了OEP。第一个负峰的延迟约为40毫秒。刺激鼻粘膜后，没有得到反应，并且在嗅觉神经切片后消失。随着重复刺激的频率的增加，幅度降低了，表明该反应是突触介导的。这些结果表明，嗅觉粘膜的电刺激后，嗅觉的诱发电位特别源自嗅觉系统。在人类中，固定在嗅觉粘膜上的刺激电极。记录来自嗅觉的OEP，在约27毫秒处记录为负峰值，类似于狗中发现的特征。人类嗅觉中的OEP还特别源自嗅觉系统。通过电刺激嗅觉粘膜获得的OEP可能被证明可用于术中监测嗅觉功能。