The Research on Hemodynamics in the Intracranial A-V Shunt Model

颅内A-V分流模型的血流动力学研究

• 批准号: 06454420
• 负责人: KODAMA Namio
• 金额: $ 4.03万
• 依托单位: Fukushima Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (B)
• 财政年份: 1993
• 资助国家: 日本
• 起止时间: 1993 至 1995
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-06454420/
• 关键词: AVM; experimental model; A-V shunt; 脳動脈奇形; 頭蓋内動静脈短絡

Hemodynamics in cerebral arteriovenous malformation (AVM) remains controversial, and the experimental model of AVM is not established. We developed the animal model of intracranial A-V shunt which revealed a focal hypoperfusion.A femoral vein graft was anastomosed end-to-side between a cortical branch of the middle cerebral artery (MCA) and the superior sagittal sinus (SSS).Using this model, the change of CBF was recorded before and after opening the shunt in the MCA territory where the anastomosis was done, as well as bilateral anterior cerebral artery (ACA) territories.In addition, the CO2 reactivity of the cerebral vessels before and after opening the shunt were examined by 5% CO2 inhalation technique in the MCA territory.The decreased rate of the local CBF in the MCA territory was significantly higher than in the bilateral ACA territory.The CBF decreased as the shunt volume increased only in the MCA territory.In the MCA territory, before opening the shunt 1-CBF increased depending on PCO2. However after opening the shunt, 1-CBF didn't increase depending on PCO2. The PCO2 reactivity in the MCA territory was impaired after opening the shunt.We developed successfully a new experimental model that has local hypoperfusion area with disturbance of CO2 reactivity.This model will be useful for the evaluating hemodynamics in cerebral A-V fistula. But this model is not the model of AVM,then we must make clear the differentiation between A-V fistula and AVM.

脑动静脉畸形（AVM）的血流动力学仍存在争议，且AVM的实验模型尚未建立。我们开发了颅内 A-V 分流动物模型，该模型显示局灶性低灌注。在大脑中动脉 (MCA) 的皮质分支和上矢状窦 (SSS) 之间端侧吻合股静脉移植物。使用该模型记录了吻合口 MCA 区域以及双侧大脑前动脉 (ACA) 区域分流器打开前后 CBF 的变化。另外，采用5%CO2吸入法检测MCA区分流术开通前后脑血管CO2反应性。MCA区局部CBF下降率明显高于双侧ACA区。仅在 MCA 区域，CBF 随着分流量的增加而减少。在 MCA 区域，在打开分流器之前，1-CBF 增加，具体取决于 PCO2。然而，打开分流器后，1-CBF 并没有根据 PCO2 增加。打开分流器后，MCA 区域的 PCO2 反应性受损。我们成功开发了一种新的实验模型，该模型具有局部低灌注区域，CO2 反应性受到干扰。该模型将有助于评估脑 A-V 瘘的血流动力学。但该模型并非AVM模型，因此必须明确A-V瘘与AVM的区别。