The spinocerebellar evoked response as an option of monitoring for inferior cerebellar peduncle dysfunction

脊髓小脑诱发反应作为监测小脑下脚功能障碍的一种选择

• 批准号: 17591523
• 负责人: KODAMA Namio
• 金额: $ 1.47万
• 依托单位: Fukushima Medical University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2005
• 资助国家: 日本
• 起止时间: 2005 至 2006
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-17591523/
• 关键词: cerebellum; evoked potential; inferior cerebellar peduncle; intraoperative monitoring; rat; spinocerebellar tract; intraoperative monitoring; 小脳; 誘発電位; 下小脳脚; 術中モニタリング; 脊髄小脳路

The aim of this study was to develop a new method for the intraoperativemonitoring of inferior cerebellar peduncle (Inf.C.Ped) function. As the dorsal spinocerebellar tract (SCT) is located in the Inf.C.Ped, we studied the possibility of using the evoked potential elicited by stimulation of the dorsal SCT and recorded from the cerebellar surface to assess the Inf.C.Ped function.The experimental study was performed in rats. Unilateral muscular contractions of quadriceps femoris muscle were elicited by electrical stimulation. The evoked potentials were recorded from the surface of the ipsilateral cerebellum and the contralateral primary sensory cortex. The highly reproducible potentials obtained from the ipsilateral cerebellar hemisphere were named spinocerebellar evoked potentials (SCEP). The SCEP exhibited one negative peak with a latency of 11.7 ± 0.3 msec (N11). Short latency somatosensory evoked potential (SSEP) was recorded from the contralateral primary sensory cortex with a latency of 19.1 ± 0.6 msec. Coagulation of the ipsilateral Inf.C.Ped caused disappearance or marked reduction of the SCEP N11 but it did not change the SSEP. On the other hand, sectioning of the ipsilateral dorsal column resulted in the disappearance of the SSEP but it did not affect the SCEP N11.Reproducible SCEP was recorded from the rat cerebellar hemisphere by electrical stimulation of the quadriceps femoris muscle. We posit that the SCEP differs from the SSEP which ascends via the dorsal column and that it is conducted by the dorsal SCT located in the Inf.C.Ped. Our results suggest that it may be possible to monitor the Inf.C.Ped in patients during cerebellar surgery.

这项研究的目的是开发一种新方法，用于下小脑花梗（INF.C.PED）功能的术中单托。由于背脊髓片（SCT）位于inf.c.，我们研究了使用背面SCT引起的潜在引起的诱发的可能性，并记录了从小脑表面进行评估INF.C.的功能。在大鼠中进行了实验研究。股四头肌的单侧肌肉收缩是通过电刺激引起的。诱发电位是从同侧小脑和对侧初级感觉皮质的表面记录的。从同侧小脑半球获得的高度可重复的电位被命名为脊椎动物诱发电位（SCEP）。旋律暴露了一个负峰，潜伏期为11.7±0.3毫秒（N11）。从对侧初级感觉皮层记录了短期潜伏期诱发电位（SSEP），潜伏期为19.1±0.6毫秒。同侧Inf.C.的凝结会导致SCEP N11的消失或明显减少，但并未改变SSEP。另一方面，同侧背侧柱的切片导致SSEP消失，但并不影响SCEP N11。可复制的SCEP通过大鼠小脑半球记录，通过股骨肌肉肌肉肌肉的电刺激。我们指出，SCEP与通过背柱上升的SSEP不同，并且由位于inf.c.ped中的背侧SCT进行。我们的结果表明，可以在小脑手术期间监测患者的INF.C。