The neurobiology of operant behavior

操作行为的神经生物学

• 批准号: 373335476
• 负责人: Professor Dr. Björn Brembs
• 金额: --
• 依托单位: Institut für Zoologie
• 依托单位国家: 德国
• 项目类别: Research Grants
• 财政年份: 2017
• 资助国家: 德国
• 起止时间: 2016-12-31 至 2018-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/373335476?language=en
• 关键词: neurobiology; operant; behavior

Over the last 15 years, the neurosciences have been adopting the perspective that the functional principle of all brains is one of constant ongoing activity. External stimuli merely modulate this activity and may be able to guide it towards specific patterns. How brains are generating these constantly fluctuating patterns of ongoing activity is still largely unclear. In this proposal we first build on our previous work in the fruit fly Drosophila, suggesting a critical role for a group of ellipsoid-body neurons in the brain of the fly for the temporal structure of spontaneous behavior. Moreover, we apply to use the modification of spontaneous behavior by reafferent feedback from behavioral outcomes to learn more about the neuronal control of spontaneous behavior. For this work we propose to use neurogenetic methods such as optogenetics and computerized analysis of the behavior of transgenic animals. Ultimate goal of the proposed research is to use this two-pronged approach to come to a fundamental, mechanistic understanding of the neuronal control of spontaneous behavior, both via internal and external factors.

在过去 15 年里，神经科学一直采用这样一种观点：所有大脑的功能原理都是持续不断的活动。外部刺激仅仅调节这种活动，并且可能能够引导它走向特定的模式。大脑如何产生这些不断波动的持续活动模式目前仍不清楚。在这项提议中，我们首先以我们之前在果蝇中的工作为基础，表明果蝇大脑中的一组椭球体神经元对于自发行为的时间结构起着关键作用。此外，我们应用通过行为结果的再传入反馈来修改自发行为，以了解更多关于自发行为的神经元控制。对于这项工作，我们建议使用神经遗传学方法，例如光遗传学和转基因动物行为的计算机分析。本研究的最终目标是利用这种双管齐下的方法，通过内部和外部因素对自发行为的神经元控制有一个基本的、机械的理解。