Genetic and Lifestyle Determinants of Cognitive Resilience in Midlife

中年认知弹性的遗传和生活方式决定因素

• 批准号: 9014375
• 负责人: OZIOMA C OKONKWO
• 金额: $ 32.46万
• 依托单位: UNIVERSITY OF WISCONSIN-MADISON
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-05-15 至 2018-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9014375
• 关键词: Adult; Adverse effects; Age; Age Factors; Age-associated memory impairment; Aging; Alleles; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer' s disease risk; Amyloid; Animals; Apolipoprotein E; Attenuated; Biological Assay; Biological Markers; Brain; Brain-Derived Neurotrophic Factor; Cerebrospinal Fluid; Clinical; Cognition; Cognitive; Cognitive aging; Data; Deterioration; Disease; Elderly; Enrollment; Epidemic; Exhibits; Family history of; Future; Genes; Genetic; Genetic Polymorphism; Genotype; Health; Heterogeneity; Human; Impaired cognition; Individual; Investigation; Life Style; Link; Liquid substance; Longevity; Mediating; Modality; Mus; N-Methyl-D-Aspartate Receptors; Neuronal Plasticity; Neurons; Participant; Pathology; Pathway interactions; Physical activity; Process; Public Health; Registries; Research; Resources; Risk; Risk Factors; Sampling; Serum; Suppressor Genes; Symptoms; Synaptic plasticity; Syndrome; Testing; Variant; Wisconsin; abeta accumulation; age effect; attenuation; brain health; clinically relevant; cognitive function; cohort; curative treatments; effective therapy; insight; lifestyle data; lifestyle factors; middle age; neuroimaging; neurotoxic; public health relevance; resilience; translational study; Adult; Adverse effects; Age; Age Factors; Age-associated memory impairment; Aging; Alleles; Alzheimer disease prevention; Alzheimer' s Disease; Alzheimer' s disease model; Alzheimer' s disease risk; Amyloid; Animals; Apolipoprotein E; Attenuated; Biological Assay; Biological Markers; Brain; Brain-Derived Neurotrophic Factor; Cerebrospinal Fluid; Clinical; Cognition; Cognitive; Cognitive aging; Data; Deterioration; Disease; Elderly; Enrollment; Epidemic; Exhibits; Family history of; Future; Genes; Genetic; Genetic Polymorphism; Genotype; Health; Heterogeneity; Human; Impaired cognition; Individual; Investigation; Life Style; Link; Liquid substance; Longevity; Mediating; Modality; Mus; N-Methyl-D-Aspartate Receptors; Neuronal Plasticity; Neurons; Participant; Pathology; Pathway interactions; Physical activity; Process; Public Health; Registries; Research; Resources; Risk; Risk Factors; Sampling; Serum; Suppressor Genes; Symptoms; Synaptic plasticity; Syndrome; Testing; Variant; Wisconsin; abeta accumulation; age effect; attenuation; brain health; clinically relevant; cognitive function; cohort; curative treatments; effective therapy; insight; lifestyle data; lifestyle factors; middle age; neuroimaging; neurotoxic; public health relevance; resilience; translational study

 DESCRIPTION (provided by applicant): Advancing age and the apolipoprotein E ε4 (APOE4) allele are key determinants of the accumulation of pathophysiological abnormalities related to Alzheimer's disease (AD), as well as the clinical manifestation of AD syndrome. However, there is substantial interindividual heterogeneity in cognitive aging and the accrual of AD pathology such that some individuals remain cognitively intact and harbor minimal AD-related brain changes even into old age, and despite being APOE4 positive. Further, although there is replicable evidence for an association between AD pathophysiological changes and cognitive impairment, this relationship is imperfect. Some individuals continue to exhibit intact cognition despite harboring substantial AD pathology. These findings underscore the existence of factors that confer resilience to (i) the influence of age and APOE4 on cognitive course and biomarker profile, and (ii) the impact of biomarker alterations on cognitive trajectory. In this project, we leverage the wealth of multimodal genetic, neuroimaging, biomarker, cognitive, and lifestyle data acquired in the Wisconsin Registry for Alzheimer's Prevention and the Wisconsin Alzheimer's Disease Research Center to study three such factors: the aging-suppressor gene KLOTHO and its systemic expression, the neuroplasticity-promoting gene brain-derived neurotrophic factor (BDNF) and its systemic expression, and physical activity. Our investigations are organized around two integrative and translational aims that seek to ascertain the extent to which KLOTHO, BDNF, and physical activity singly or jointly modify the effect of age and APOE4 on cognitive trajectory (Aim 1) and neuroimaging and fluid biomarkers of AD (Aim 2) in middle-aged adults (N ≈ 2000) at increased risk for AD. We will also determine whether these resilience factors alter the pernicious influence of biomarker changes on cognitive course. Together, this complementary set of studies will provide critical insights into putative avenues for promoting brain and cognitive health, particularly against the constraints imposed by advancing age and APOE4 genotype.

 描述（由适用提供）：促进年龄和载脂蛋白Eε4（APOE4）等位基因是与阿尔茨海默氏病（AD）以及AD AD综合征的临床表现相关的病理生理异常积累的关键决定者。但是，认知衰老和AD病理学的核心存在实质性的异质性，使得某些人保持完整性的状态，并且与大脑有关，即使是老年，与APOE4相关的大脑变化也很小，并且目的地为APOE4阳性。此外，尽管有可复制的证据表明AD病理生理变化与认知障碍之间存在关联，但这种关系并不完美。尽管有大量的AD病理学，但一些人仍继续表现出完整的认知。这些发现强调了赋予（i）年龄和APOE4对认知过程和生物标志物概况的影响的因素的存在，以及（ii）生物标志物改变对认知轨迹的影响。 In this project, we leverage the wealth of multimodal genetic, neuroimaging, biomarker, cognitive, and lifestyle data acquired in the Wisconsin Registry for Alzheimer's Prevention and the Wisconsin Alzheimer's Disease Research Center to study three such factors: the aging-suppressor gene KLOTHO and its systemic expression, the neuroplasticity-promoting gene brain-derived神经营养因子（BDNF）及其系统性表达和体育活动。我们的投资是围绕两个集成和翻译的目标进行组织的，这些目标旨在确定Klotho，BDNF和体育锻炼单独或共同修改年龄和APOE4对认知轨迹的影响（AIM 1）以及AD（n约2000年）的AD（AIM 2）AD的神经影像和流体生物标志物（AIM 2）。我们还将确定这些弹性因素是否改变了生物标志物变化对认知过程的有害影响。总之，这组完整的研究将为促进大脑和认知健康的推定途径提供关键的见解，尤其是针对增长年龄和APOE4基因型所施加的限制。