Elucidation of the mutualistic relationship between host and gut microbiota mediated by mucin and its application

粘蛋白介导的宿主与肠道菌群互利关系的阐明及其应用

• 批准号: 20H02929
• 负责人: MORITA Tatsuya
• 金额: $ 10.98万
• 依托单位: Shizuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2020
• 资助国家: 日本
• 起止时间: 2020-04-01 至 2023-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-20H02929/
• 关键词: ムチン; 腸内細菌叢; 短鎖脂肪酸; 腸内細菌; 相利共生; 腸管バリア

项目成果

Mucin-Derived O-Glycans Act as Endogenous Fiber and Sustain Mucosal Immune Homeostasis via Short-Chain Fatty Acid Production in Rat Cecum

粘蛋白衍生的 O-聚糖作为内源性纤维，通过大鼠盲肠中短链脂肪酸的产生维持粘膜免疫稳态

• DOI: 10.1093/jn/nxaa097
• 发表时间: 2020
• 影响因子: 4.2
• 作者: Hino S; Mizushima T; Kaneko K; Kawai E; Kondo T; Genda T; Yamada T; Hase K; Nishimura N; Morita T
• 通讯作者: Morita T

Oral Intake of Slowly Digestible α-Glucan Such as Resistant Maltodextrin Leads to Increased Secretion of Glucagon-Like Peptide-2 in Rats and Helps Thicken Their Ileal Mucosae

口服缓慢消化的 α-葡聚糖（例如抗性麦芽糖糊精）会导致大鼠胰高血糖素样肽 2 的分泌增加，并有助于增厚其回肠粘膜

• DOI: 10.3177/jnsv.68.104
• 发表时间: 2022
• 影响因子: 1.6
• 作者: GOTO Tomoya;UMEDA Tomoki;HINO Shingo;MORITA Tatsuya;NISHIMURA Naomichi
• 通讯作者: NISHIMURA Naomichi

Hairy Region Concentrate of Pectin Strongly Stimulates Mucin Secretion in HT29-MTX Cells, but to a Lessor Degree in Rat Small Intestine

毛状区域浓缩果胶强烈刺激 HT29-MTX 细胞中的粘蛋白分泌，但在大鼠小肠中刺激程度较小

• DOI: 10.3177/jnsv.66.331
• 发表时间: 2020
• 影响因子: 1.6
• 作者: HINO Shingo;NISHIMURA Naomichi;MORITA Tatsuya
• 通讯作者: MORITA Tatsuya

Skate-skin mucin, rich in sulfated sugars and threonine, promotes proliferation of Akkermansia muciniphila in feeding tests in rats and in vitro fermentation using human feces

富含硫酸化糖和苏氨酸的滑冰皮粘蛋白在大鼠喂养试验和使用人类粪便的体外发酵中促进 <i>Akkermansia muciniphila</i> 的增殖

• DOI: 10.1093/bbb/zbac003
• 发表时间: 2022
• 作者: Miyata Takaaki;Mizushima Takayasu;Miyamoto Nobuyuki;Yamada Takahiro;Hase Koji;Fukushima Michihiro;Nishimura Naomichi;Hino Shingo;Morita Tatsuya
• 通讯作者: Morita Tatsuya

Mucin-Derived O-Glycans Act as Endogenous Fiber and Sustain Mucosal Immune Homeostasis via Short-Chain Fatty Acid Production in Rat Cecum

粘蛋白衍生的 O-聚糖作为内源性纤维，通过大鼠盲肠中短链脂肪酸的产生维持粘膜免疫稳态

• DOI: 10.1093/jn/nxaa097
• 发表时间: 2020
• 影响因子: 4.2
• 作者: Hino S; Mizushima T; Kaneko K; Kawai E; Kondo T; Genda T; Yamada T; Hase K; Nishimura N; Morita T
• 通讯作者: Morita T