MRI: Track 1 Acquisition of a Single Crystal X-Ray Diffractometer for Chemical and Biological Structure Determination

MRI：轨道 1 获取单晶 X 射线衍射仪，用于化学和生物结构测定

• 批准号: 2320780
• 负责人: Ana de Bettencourt-Dias
• 金额: $ 40.44万
• 依托单位: Board of Regents, NSHE, obo University of Nevada, Reno
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320780&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; Single; Crystal

This award is jointly funded by the Major Research Instrumentation Program, the Chemistry Research Instrumentation Program, and the Established Program to Stimulate Competitive Research (EPSCoR). The University of Nevada, Reno is purchasing a single crystal diffractometer equipped with copper and molybdenum sources to support the research of Professor Ana de Bettencourt-Dias with colleagues Yftah Tal-Gan and Christopher Jeffrey. This instrument facilitates research in luminescent materials and f element chemistry, bacterial communication and quorum sensing, chemical ecology, and natural products chemistry. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The features of this instrument enhance the research efforts of faculty and students; it is also successfully deployed as part of the teaching efforts of students at all levels in many departments at the University of Nevada, Reno and in teaching and outreach in the Northern Nevada region. Most notably, students from area high schools learn about the technique, and the history of its development, and have access to determine the structure of simple compounds isolated as part of their science curriculum. The award is aimed at enhancing research and education at all levels. The research enabled by the acquisition of this instrument spans a wide range of areas in chemistry, biochemistry, biology and materials science, namely, luminescent materials, f element chemistry, bacterial communication and quorum sensing, chemical ecology, organometallic chemistry and catalysis, medicinal chemistry, molecular materials for electronics applications, polyaromatic hydrocarbons, sensors, theranostics, f element separation, metallacycles, biological activity of polyacetylenes, biopolymers, plant cell wall biology and muscle proteins. The availability of the instrument with dual copper and molybdenum sources allows the research groups to gain insights from the structural characterization of small molecules, macromolecules and metalorganic frameworks, and the determination of absolute structure of light-atom molecules. These further our knowledge in the areas mentioned above, and the structural information collected cannot be accessed by any other technique. The research of a total of 16 investigators and their research groups spanning 5 institutions, which include 2 NSF CAREER recipients, 4 junior, 5 female and 4 Hispanic investigators, is impacted by the availability of the instrument. Students from varied socio-economic backgrounds have access to a technique that is not usually part of the undergraduate curriculum, which provides them with an important marketable skill. In addition, a collaboration with a local school provides high school seniors with a more in-depth understanding of the importance of structural characterization in the sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由主要的研究工具计划，化学研究工具计划和启发竞争性研究（EPSCOR）的既定计划共同资助。内华达大学里诺大学正在购买配备铜和钼源的单晶衍射仪，以支持Ana de Bettencourt-Dias教授与同事Yftah Tal-Gan和Christopher Jeffrey的研究。该仪器促进了发光材料和F元素化学，细菌交流和法定感应，化学生态学和天然产品化学的研究。通常，X射线衍射仪可以准确，精确地测量分子的完整三维结构，包括键距离和角度，并提供有关分子相对于相邻分子的空间排列的准确信息。该乐器的特征增强了教师和学生的研究工作；在内华达大学，里诺大学的许多系以及内华达州北部地区的教学和外展活动中，它也成功部署了学生的教学工作的一部分。最值得注意的是，来自地区高中的学生了解了该技术及其发展的历史，并可以确定作为其科学课程一部分隔离的简单化合物的结构。该奖项旨在增强各级研究和教育。 The research enabled by the acquisition of this instrument spans a wide range of areas in chemistry, biochemistry, biology and materials science, namely, luminescent materials, f element chemistry, bacterial communication and quorum sensing, chemical ecology, organometallic chemistry and catalysis, medicinal chemistry, molecular materials for electronics applications, polyaromatic hydrocarbons, sensors, theranostics, f element separation,金属环，聚乙烯烯，生物聚合物，植物细胞壁生物学和肌肉蛋白的生物学活性。具有双铜和钼源的仪器的可用性使研究组可以从小分子的结构表征，大分子和金属有机框架中获得见解，并确定光原子分子的绝对结构。这些进一步的知识在上面提到的领域以及收集的结构信息无法通过任何其他技术访问。 该工具的可用性影响了16名调查人员及其研究小组的研究，其中包括2名NSF职业接受者，4名初中，5名女性和4名西班牙裔研究人员。来自不同社会经济背景的学生可以使用通常不属于本科课程的技术，该技术为他们提供了重要的出售技能。此外，与当地学校的合作为高中生提供了对科学结构表征重要性的更深入的理解。该奖项反映了NSF的法定任务，并认为值得通过基金会的智力优点和更广泛的影响评估标准通过评估来获得支持。