MRI: Track 1 Acquisition of a Single Crystal X-Ray Diffractometer for Chemical and Biological Structure Determination

MRI：轨道 1 获取单晶 X 射线衍射仪，用于化学和生物结构测定

• 批准号: 2320780
• 负责人: Ana de Bettencourt-Dias
• 金额: $ 40.44万
• 依托单位: Board of Regents, NSHE, obo University of Nevada, Reno
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-01 至 2026-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2320780&HistoricalAwards=false
• 关键词: MRI; Track; Acquisition; Single; Crystal

This award is jointly funded by the Major Research Instrumentation Program, the Chemistry Research Instrumentation Program, and the Established Program to Stimulate Competitive Research (EPSCoR). The University of Nevada, Reno is purchasing a single crystal diffractometer equipped with copper and molybdenum sources to support the research of Professor Ana de Bettencourt-Dias with colleagues Yftah Tal-Gan and Christopher Jeffrey. This instrument facilitates research in luminescent materials and f element chemistry, bacterial communication and quorum sensing, chemical ecology, and natural products chemistry. In general, an X-ray diffractometer allows accurate and precise measurements of the full three-dimensional structure of a molecule, including bond distances and angles, and provides accurate information about the spatial arrangement of a molecule relative to neighboring molecules. The features of this instrument enhance the research efforts of faculty and students; it is also successfully deployed as part of the teaching efforts of students at all levels in many departments at the University of Nevada, Reno and in teaching and outreach in the Northern Nevada region. Most notably, students from area high schools learn about the technique, and the history of its development, and have access to determine the structure of simple compounds isolated as part of their science curriculum. The award is aimed at enhancing research and education at all levels. The research enabled by the acquisition of this instrument spans a wide range of areas in chemistry, biochemistry, biology and materials science, namely, luminescent materials, f element chemistry, bacterial communication and quorum sensing, chemical ecology, organometallic chemistry and catalysis, medicinal chemistry, molecular materials for electronics applications, polyaromatic hydrocarbons, sensors, theranostics, f element separation, metallacycles, biological activity of polyacetylenes, biopolymers, plant cell wall biology and muscle proteins. The availability of the instrument with dual copper and molybdenum sources allows the research groups to gain insights from the structural characterization of small molecules, macromolecules and metalorganic frameworks, and the determination of absolute structure of light-atom molecules. These further our knowledge in the areas mentioned above, and the structural information collected cannot be accessed by any other technique. The research of a total of 16 investigators and their research groups spanning 5 institutions, which include 2 NSF CAREER recipients, 4 junior, 5 female and 4 Hispanic investigators, is impacted by the availability of the instrument. Students from varied socio-economic backgrounds have access to a technique that is not usually part of the undergraduate curriculum, which provides them with an important marketable skill. In addition, a collaboration with a local school provides high school seniors with a more in-depth understanding of the importance of structural characterization in the sciences.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

该奖项由重大研究仪器计划、化学研究仪器计划和刺激竞争性研究既定计划 (EPSCoR) 共同资助。内华达大学里诺分校正在购买一台配备铜和钼源的单晶衍射仪，以支持 Ana de Bettencourt-Dias 教授及其同事 Yftah Tal-Gan 和 Christopher Jeffrey 的研究。该仪器促进了发光材料和 f 元素化学、细菌通讯和群体感应、化学生态学和天然产物化学的研究。一般来说，X 射线衍射仪可以精确测量分子的完整三维结构，包括键距和角度，并提供有关分子相对于相邻分子的空间排列的准确信息。该仪器的特点增强了教师和学生的研究力度；它还成功地应用于内华达大学里诺分校许多系的各级学生教学工作以及北内华达地区的教学和外展工作。最值得注意的是，来自地区高中的学生了解该技术及其发展历史，并有机会确定作为其科学课程一部分的简单化合物的结构。该奖项旨在加强各级研究和教育。购买该仪器所实现的研究涵盖化学、生物化学、生物学和材料科学的广泛领域，即发光材料、f元素化学、细菌通讯和群体感应、化学生态学、有机金属化学和催化、药物化学、电子应用分子材料、聚芳烃、传感器、治疗诊断、f 元素分离、金属环、聚乙炔的生物活性、生物聚合物、植物细胞壁生物学和肌肉蛋白。该仪器具有铜和钼双源，使研究小组能够从小分子、大分子和金属有机框架的结构表征以及轻原子分子绝对结构的测定中获得见解。这些进一步加深了我们在上述领域的知识，并且收集的结构信息无法通过任何其他技术访问。 跨越 5 个机构的总共 16 名研究人员及其研究小组的研究受到仪器可用性的影响，其中包括 2 名 NSF CAREER 获得者、4 名初级研究人员、5 名女性和 4 名西班牙裔研究人员。来自不同社会经济背景的学生可以获得通常不属于本科课程一部分的技术，这为他们提供了重要的市场技能。此外，与当地学校的合作使高中生能够更深入地了解结构表征在科学中的重要性。该奖项反映了 NSF 的法定使命，并通过使用基金会的智力优势进行评估，被认为值得支持以及更广泛的影响审查标准。