Lanthanide Ion Complexes with Viscosity- or Temperature-dependent Emission

具有粘度或温度依赖性发射的镧系离子配合物

• 批准号: 2155047
• 负责人: Ana de Bettencourt-Dias
• 金额: $ 48.5万
• 依托单位: Board of Regents, NSHE, obo University of Nevada, Reno
• 依托单位国家: 美国
• 项目类别: Continuing Grant
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-01 至 2025-08-31
• 项目状态: 未结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=2155047&HistoricalAwards=false
• 关键词: Lanthanide; Ion; Complexes; Viscosity; Temperature

In this project, funded by the Chemical Structure, Dynamics & Mechanisms B and the Chemical Measurement and Imaging Programs of the Chemistry Division of the National Science Foundation, Professor Ana de Bettencourt-Dias and her research group at the University of Nevada, Reno, will isolate lanthanide ion complexes capable of metal-centered light emission. They plan to demonstrate that this light emission can be modulated by viscosity and temperature and they will study the compound design features that best enable this modulation. With the ability to correlate the intensity of the emitted light with the temperature and the viscosity, the group will be able to measure the temperature and viscosity inside of the cells. These properties vary with the type of cell and are important properties to help in the diagnosis of disease and in the unraveling of cell metabolism. The research is also of interest in the management of industrial processes, such as monitoring completion of polymerization and hydrogelation processes. During the project, undergraduate and graduate students as well as postdoctoral scholars will be trained in the synthesis and spectroscopic techniques needed to successfully complete the proposed work. As part of the commitment to support the advancement and inclusivity of underrepresented minority faculty, Professor Ana de Bettencourt-Dias will continue mentoring junior colleagues and promoting their science through a variety of avenues, including, but not limited to, the Periodic TableTalks. Lanthanide ions display sharp emission profile. This emission, which arises from transitions within the 4f orbitals, is most efficiently sensitized through coordinated ligand chromophores. These chromophores can be designed to display an energy transfer to the emissive lanthanide ion, which is modulated by viscosity and temperature. In this project, Professor Ana de Bettencourt-Dias and her research group propose to isolate several new ligands, based on N-heterocycles and cyanovinyl molecular rotors, and to assess their ability to promote metal-ion centered emission as a function of the temperature and viscosity of the medium. In addition, they will study, by using heteroleptic complexes, which ligand functionalities enable the viscosity- and temperature-dependent emission through a two-photon excitation process.This award reflects NSF's statutory mission and has been deemed worthy of support through evaluation using the Foundation's intellectual merit and broader impacts review criteria.

在这个项目中，由化学结构，动力学和机制B以及国家科学基金会化学部的化学测量和成像计划资助，安娜·德·贝滕库特·迪亚斯教授及其内华达大学里诺大学的研究小组将分离的灯笼型离子配合物，能够以金属为中心的光发射。他们计划证明这种光发射可以通过粘度和温度来调节，并将研究最能使这种调制的复合设计功能。 具有将发光的强度与温度和粘度相关联的能力，该组将能够测量细胞内部的温度和粘度。这些特性随细胞的类型而变化，并且是帮助诊断疾病和细胞代谢的重要特性。 这项研究也对工业过程的管理感兴趣，例如监测聚合和水凝胶过程的完成。 在该项目期间，本科生和研究生以及博士后学者将接受成功完成拟议工作所需的合成和光谱技术的培训。作为支持不足少数群体教师的进步和包容性的承诺的一部分，Ana de Bettencourt-Dias教授将继续指导初级同事，并通过各种途径（包括但不限于定期片剂）通过各种途径来促进他们的科学。灯笼离子显示出尖锐的排放曲线。这种发射是由4F轨道内的过渡产生的，它是通过协调的配体发色团最有效地敏化的。这些发色团可以设计用于向发射灯笼离子的能量转移，该离子受粘度和温度调节。在该项目中，Ana de Bettencourt-Dias教授及其研究小组建议基于N-杂环和氰基分子转子分离几种新的配体，并评估其促进金属离子中心排放的能力，并促进金属离子以温度和温度和温度的函数介质的粘度。此外，他们将通过使用异质化复合物来研究，配体功能可以通过两光子激发过程使粘度和温度依赖性发射。这项奖项反映了NSF的法定任务，并被认为是值得通过基金会的评估来通过评估来支持的。智力优点和更广泛的影响审查标准。