EAGER: Nanostructured Colorimetric Polymer For Pathogen Detection

EAGER：用于病原体检测的纳米结构比色聚合物

基本信息

批准号：
0947771
负责人：
Peter Kofinas
金额：
$ 12万
依托单位：
University of Maryland, College Park
依托单位国家：
美国
项目类别：
Standard Grant
财政年份：
2009
资助国家：
美国
起止时间：
2009-08-15 至 2010-07-31
项目状态：
已结题

来源：
https://www.nsf.gov/awardsearch/showAward?AWD_ID=0947771&HistoricalAwards=false
关键词：
EAGER Nanostructured Colorimetric Polymer Pathogen

项目摘要

0947771KofinasThe goal of this exploratory research is to synthesize and process polymer thin films capable of recognizing a variety of bacterial pathogens. Such flexible polymers could be applied as an insert on food packaging products, or as a swab in a hospital setting which, upon recognition of pathogens such as Escherichia coli, Listeria, Salmonella, Campylobacter, Legionella, undergo a color change providing manufacturers, consumers, and healthcare workers with a facile method for identifying contamination. The proposed polymer thin films consist of a layered structure which changes thickness upon recognition of small molecules, "autoinducers", that bacteria secrete to communicate with each other. The thickness change results in a color change which can be visually observed. Sensors based on such block copolymer films will be unique in their ability to selectively recognize bacterial signaling molecules without the need for additional dyes or ligands. This will result in a radically different approach for sensor fabrication, resulting in low-cost sensors for quality monitoring and preservation of a large number of food products. The education activities to be undertaken in this work are designed to educate and train a next-generation engineers that embrace diversity as a strength. We have several initiatives planned including specific programs that assist in undergraduate and graduate education, graduate student mentoring, and training of high school students from schools in minority-rich communities.

0947771Kofinas这项探索性研究的目标是合成和处理能够识别多种细菌病原体的聚合物薄膜。这种柔性聚合物可以用作食品包装产品的插入物，或者在医院环境中签名，在识别诸如Escherichia Coli，Listeria，Listeria，Salmonella，Salmonella，Campylobacter，campylobacter，empionella之类的病原体后，会经过颜色变化，以提供制造商，消费者，消费者，消费者，消费者，，消费者，，消费者，，消费者，，消费者，，，消费者，，，消费者，消费者，，，，消费者，消费者，，，，消费者，消费者，，换颜色。以及具有轻松识别污染的方法的医疗保健工人。提出的聚合物薄膜由一个分层结构组成，该结构在识别小分子“自动诱导剂”时会改变厚度，该细菌分泌彼此交流。厚度变化会导致颜色变化，可以在视觉上观察到。基于此类块共聚物膜的传感器在无需其他染料或配体的情况下选择性地识别细菌信号分子的能力将是独一无二的。这将导致一种完全不同的传感器制造方法，从而导致低成本的传感器，用于质量监测和保存大量食品。这项工作中要进行的教育活动旨在教育和培训以多样性为优势的下一代工程师。我们计划了几项计划，包括有助于本科和研究生教育的特定计划，研究生指导以及对少数富裕社区学校的高中生培训。