ACT/SGER: Virus Recognition Using Self-Assembled Nanoscale Block Copolymer Patterns

ACT/SGER：使用自组装纳米级嵌段共聚物图案进行病毒识别

• 批准号: 0346253
• 负责人: Peter Kofinas
• 金额: $ 10万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-09-01 至 2005-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0346253&HistoricalAwards=false
• 关键词: ACT; SGER; Virus; Recognition; Using

This exploratory proposal will present a new method which uses a Nickel-functionalized amphiphilic block copolymer pattern to separate and collect viruses. Block copolymers can provide flexible transparent functional nanoscale devices with non-lithographic nanoscale patterns which could be made compatible with biologically active molecules.The proposed work is divided into two specific objectives: The first deals with synthesizing and processing functionalized block copolymers, the second will apply these materials to biomimetic virus sensing.1. Nickel functionalized block copolymers will be synthesized and processed into thin films.2. Virus binding of different sizes and shapes (BV-GFP, TMV, TNV, PVX, CGMMV) will be carried out, and their specificity on the block copolymer pattern will be evaluated in aqueous and physiological media.The proposed exploratory methodologies for the synthesis and characterization of thin-film virus binding nanoscale polymer patterns thus offer exciting avenues for the development of novel biosensing materials and techniques. The broader impacts of the proposed exploratory research relate to a block copolymer nanoscale device system which would apply in the identification, classification, and removal of viruses. This is currently a very difficult task, but the need is widespread in diverse sectors, including national security (e.g. bioterrorism), human and animal health, crop protection, and biologics production. The education activities to be undertaken in this work include undergraduate and graduate teaching, middle school teacher training, graduate student advising, and various opportunities in undergraduate research involvement and mentoring, as well as the development of a K-12 tailored interactive web page.This award is supported jointly by the NSF and the Intelligence Community. The Approaches to Combat Terrorism Program in the Directorate for Mathematics and Physical Sciences supports new concepts in basic research and workforce development with the potential to contribute to national security.

该探索性提案将提出一种使用镍官能化两亲性嵌段共聚物模式来分离和收集病毒的新方法。 嵌段共聚物可以提供具有非光刻纳米级图案的柔性透明功能纳米级器件，这些器件可以与生物活性分子兼容。所提出的工作分为两个具体目标：第一个涉及合成和加工功能化嵌段共聚物，第二个将应用于这些材料用于仿生病毒传感。 1．合成镍功能化嵌段共聚物并加工成薄膜。 2．将进行不同大小和形状的病毒结合（BV-GFP、TMV、TNV、PVX、CGMMV），并将在水性和生理介质中评估它们对嵌段共聚物模式的特异性。所提出的合成和合成的探索性方法因此，薄膜病毒结合纳米级聚合物图案的表征为新型生物传感材料和技术的开发提供了令人兴奋的途径。 拟议的探索性研究的更广泛影响涉及嵌段共聚物纳米级装置系统，该系统将应用于病毒的识别、分类和去除。 目前这是一项非常艰巨的任务，但需求广泛存在于各个领域，包括国家安全（例如生物恐怖主义）、人类和动物健康、作物保护和生物制品生产。 这项工作将开展的教育活动包括本科生和研究生教学、中学教师培训、研究生咨询、本科生研究参与和指导的各种机会，以及 K-12 定制互动网页的开发。该奖项由美国国家科学基金会和情报界共同支持。 数学和物理科学局的打击恐怖主义方案方案支持基础研究和劳动力发展方面的新概念，有可能为国家安全做出贡献。