Isomeric Sugar Recognition Using Molecularly Imprinted Polymer Hydrogels

使用分子印迹聚合物水凝胶进行异构糖识别

• 批准号: 0303951
• 负责人: Peter Kofinas
• 金额: $ 25.62万
• 依托单位: University of Maryland, College Park
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-15 至 2007-03-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0303951&HistoricalAwards=false
• 关键词: Isomeric; Sugar; Recognition; Using; Molecularly

AbstractProposal Title: Isomeric Sugar Recognition Using Molecularly Imprinted Polymer HydrogelsProposal Number: CTS-0303951Principal Investigator: Peter KofinasInstitution: University of MarylandThe objective of the proposed research is to prepare and test polymer hydrogels that have been molecularly imprinted with recognition properties for different materials. Molecularly imprinted polymers (MIP) will be synthesized and imprinted against specific simple sugar isomers. Methods will be developed for the detection and quantification of each molecular imprint. The MIP's total sugar binding, specificity, and rate of sugar diffusion will be evaluated in aqueous and physiological media. Specific sugar recognition will be optimized through combinatorial synthesis methods. A non-covalent approach to imprinting will be carried out in aqueous solution. Mechanistic studies will attempt to clarify the roles of molecular shape and functionality on selectivity. In terms of the broader impacts, novel MIPs might offer new avenues for biorecognition and isomeric separation techniques. The MIPs developed in this study may be used for bio-separations in conjunction with chromatographic techniques to separate amino acids, sugars, drugs, viruses and other bioactive compounds. In previous work K-12 activities have been developed. An interactive Website for K-12 will be developed in this project.

摘要普罗帕萨尔标题：使用分子烙印的聚合物Hydrogelspropoposal编号：CTS-0303951原理研究者：Peter Kofinasinstitution：马里兰大学的目标是准备和测试具有分子识别物质具有不同材料的物质的物质的目标。 分子印刷聚合物（MIP）将与特定的简单糖异构体合成并印刷。 将开发用于检测和定量每个分子烙印的方法。 MIP的总糖结合，特异性和糖扩散速率将在水性和生理培养基中进行评估。 特定的糖识别将通过组合合成方法优化。 在水溶液中将采用一种非共价烙印方法。 机械研究将试图阐明分子形状和功能在选择性中的作用。 就更广泛的影响而言，新颖的MIP可能为生物识别和异构分离技术提供新的途径。 这项研究中开发的MIP可以与色谱技术结合使用，以分离氨基酸，糖，药物，病毒和其他生物活性化合物。 在先前的工作中，K-12的活动已经开发出来。 该项目将开发针对K-12的交互式网站。