MRI: Acquisition of Matrix-Assisted Laser Desorption Ionization and Electrospray Ionization Mass Spectrometers for the Analysis of New Synthetic Polymers and Materials

MRI：购买基质辅助激光解吸电离和电喷雾电离质谱仪，用于分析新型合成聚合物和材料

• 批准号: 0821313
• 负责人: Chrys Wesdemiotis
• 金额: $ 78.86万
• 依托单位: University of Akron
• 依托单位国家: 美国
• 项目类别: Standard Grant
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-01 至 2011-08-31
• 项目状态: 已结题
• 来源: https://www.nsf.gov/awardsearch/showAward?AWD_ID=0821313&HistoricalAwards=false
• 关键词: MRI; Acquisition; Matrix; Assisted; Laser

Technical AbstractMatrix-assisted laser desorption ionization (MALDI) and electrospray ionization (ESI) mass spectrometers will be acquired for the analysis of synthetic, macromolecular materials. The instruments will support a variety of interdisciplinary research programs in polymer science and engineering at the University of Akron, which focus on the creation of new polymers and materials and the examination of these substances for specific applications. The studies performed within this research regularly raise questions about the mass, composition, functional groups, purity, connectivity, and architecture of functionalized oligomers and macromonomers, hyperbranched and dendritic systems, organic and inorganic polymers, copolymers, polymer interfaces, and polymer-biomolecule conjugates. These questions can be answered with exceptional sensitivity and specificity by combined MALDI time-of-flight and ESI ion trap / time-of-flight mass spectrometry analyses. The high resolution, high mass accuracy, and tandem mass spectrometry capabilities of the instruments to be obtained will significantly facilitate the desired structural characterizations, fostering the development of new methods of polymerization and the discovery of new materials with properties fine-tuned for particular technological uses, inter alia, in photovoltaic devices, sensors, or drug delivery systems. The instruments will be accessible to industrial researchers and college faculty from Northeast Ohio, who need ESI or MALDI mass spectrometry to solve their analytical problems. They will also be available for a variety of educational activities, including instrumental analysis courses and research courses for graduate, undergraduate, REU, and McNair students.Non-Technical AbstractThe University of Akron (UA) will purchase instruments to study structure and enhance research and education in many interconnected research projects in polymer science and engineering. Currently, researchers at UA focus on the preparation of new materials; on the mechanical, physical, and chemical properties of these materials; and on the optimization of their properties for specific applications in nanotechnology and biomedical fields. For example, materials for light harvesting devices, biosensors, stents, implants, and drug delivery systems are being studied. The research naturally leads to questions about the chemical make-up, size, and purity of the materials. The mass spectrometry equipment requested will enable rapid and accurate measurement of these properties and lead to the making of new materials. The problem solving capability of the instruments will make the discovery of new materials easier and allow the properties of the materials to be fine-tuned for the desired use. The instruments will be used by academic and industrial researchers within the Ohio Mass Spectrometry Consortium (universities, other research institutions, and affiliated industrial corporations) as well as by college faculty from universities in Northeast Ohio. The instruments will also be available for a variety of educational activities, including undergraduate courses in instrumental analysis and research courses for graduate and undergraduate students.

将获取技术摘要的激光解离电离（MALDI）和电喷雾电离（ESI）质谱仪，以分析合成的大分子分子材料。 这些工具将支持阿克伦大学聚合物科学和工程学的各种跨学科研究计划，该计划的重点是创建新的聚合物和材料，并检查这些物质以用于特定应用。 在这项研究中进行的研究定期提出有关功能化的低聚物和宏观工程学，超支和树突状系统，有机和无机聚合物，共聚物，共聚物，聚合物，聚合物 - 聚合物 - 聚合物 - 聚合物 - 聚合物 - 聚合物 - 聚合物 - 聚合物 - 聚合物 - 聚合物 - 聚合物 - 聚合物聚合物结合物的质量，组成，官能团，纯度，纯度，连通性和结构。 通过合并的MALDI飞机和Esi离子陷阱 /飞行时间质谱分析，可以通过出色的灵敏度和特异性来回答这些问题。 要获得的仪器的高分辨率，高质量准确性和串联质谱能力将显着促进所需的结构特征，从而促进了新的聚合方法的开发，并发现具有特定技术用途的特性的新材料的发现，在Photovoltaic Depptlaic Depptlaic Depptlaic Devices，或使用药物，或药物传递器中使用了特定技术用途。 俄亥俄州东北部的工业研究人员和大学教师将可以使用这些工具，他们需要ESI或MALDI质谱来解决他们的分析问题。 它们还将用于各种教育活动，包括工具分析课程和研究生，本科，REU和McNair学生的研究课程。非技术摘要Akron大学（UA）将购买研究结构的工具，并在许多相互联系的研究项目中研究结构并增强聚合物科学和工程研究项目的研究和教育。 目前，UA的研究人员专注于准备新材料。这些材料的机械，物理和化学特性；以及对纳米技术和生物医学领域中特定应用的优化。 例如，正在研究用于轻收集设备，生物传感器，支架，植入物和药物输送系统的材料。 该研究自然会导致有关材料的化学构成，尺寸和纯度的问题。 所需的质谱设备将能够快速准确地测量这些特性，并导致制造新材料。 仪器的解决能力将使发现新材料的发现更加容易，并允许对材料的特性进行微调以供所需的使用。 这些工具将在俄亥俄州群众光谱法财团（大学，其他研究机构和附属工业公司）以及俄亥俄州东北大学的大学教师中使用这些工具。 这些仪器还将用于各种教育活动，包括工具分析中的本科课程以及研究生和本科生的研究课程。